Cyclodextrin Monomers and Polymers for Drug Activity Enhancement

Matencio, Adrián; Hoti, Gjylije; Monfared, Yousef Khazaei; Rezayat, Azam; Pedrazzo, Alberto Rubin; Caldera, Fabrizio; Trotta, Francesco

doi:10.3390/polym13111684

Cited by 32 publications

(27 citation statements)

References 174 publications

(182 reference statements)

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“…However, several of the studies reported showed a higher increase in concentration with CD-based polymers when compared to CD monomers, such as the case of KYNA [ 62 ], where the solubility increased 6.7-fold between CD monomers and polymers. This increase in solubility has been reported as an eventual increase in bioavailability [ 10 ]. For future uses, the degradation of bonds of CD-based polymers should be considered.…”

Section: Critical Overview Of the Capacity Toxicity And Current Status Of Cd-based Materialsmentioning

confidence: 80%

“…In general, the inclusion complex formation improves the apparent solubility of the drug, which increases its final concentration, even affecting the BaC structure and possibly its bioactivities [ 4 , 5 , 6 , 7 , 8 , 9 ]. However, other effects such as increased stability, controlled release or chiral separation occur when the inclusion complex is formed [ 10 ]. Finally, their uses as active agents (without a guess) are being also studied for different diseases or applications [ 3 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Advances and Classification of Cyclodextrin-Based Polymers for Food-Related Issues

et al. 2021

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Cyclodextrins (CDs) are a good alternative to reduce or enhance different biomolecule characteristics and have demonstrated great results in food science. However, CDs present intrinsic limitations that can be solved by derivative synthesis. This review represents a survey of the state of the art of CD-based materials and their uses in food science. A deep review of the structure is carried out and different groups for ordination are suggested. After that, different applications such as cholesterol complexation or its use as sensors are reviewed. The derivatives show novel and promising activities for the industry. A critical perspective of the materials suggests that they might not present toxicity, although more studies are required. These points suggest that the research in this field will be increased in the following years.

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Section: Critical Overview Of the Capacity Toxicity And Current Status Of Cd-based Materialsmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Advances and Classification of Cyclodextrin-Based Polymers for Food-Related Issues

et al. 2021

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“…In the light of the considerations made above, it is clear that CDs respond to the need to optimize treatments that already exist, making them more effective, stable and safe. Encapsulation of CDs has been demonstrated to be efficient in solving these kind of issues [ 8 , 118 ] while maintaining or even increasing the biological activity of these agents because they act as multifunctional excipients in that they are solubility enhancers, prevent drug–drug and drug–additive interactions within a formulation, eliminate unpleasant smells or tastes and reduce side effects [ 5 , 53 , 119 , 120 ]. Even their own activity as active drugs could promote possible synergetic capacities [ 116 ].…”

Section: Discussionmentioning

confidence: 99%

Cyclodextrins as Anti-inflammatory Agents: Basis, Drugs and Perspectives

et al. 2021

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Inflammation is a biological response of the immune system to harmful stimuli. Importantly, inflammation is also a hallmark of several human diseases such as cancer or diabetes. Novel drugs to treat this response are constantly researched, but the formulation is usually forgotten. Cyclodextrins (CDs) are a well-known excipient for complexing and drug delivery. Anti-inflammatory drugs and bioactive compounds with similar activities have been favored from these CD processes. CDs also illustrate anti-inflammatory activity per se. This review tried to describe the capacities of CDs in this field, and is divided into two parts: Firstly, a short description of the inflammation disease (causes, symptoms, treatment) is explained; secondly, the effects of different CDs alone or forming inclusion complexes with drugs or bioactive compounds are discussed.

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“…In fact, the intrinsic structure of CDs allows the synthesis and design of CD-based polymers with specific functions and assemblies [ 78 ]. This route is suitable to improve the properties and the activity of different active substances [ 27 , 79 ].…”

Section: Incorporation Of Active Substances In Polymeric Matrix Composites For Active Packaging Applicationsmentioning

confidence: 99%

“…To summarize, the most relevant studies regarding the use of cyclodextrin inclusion complexes (CICs) in active food packaging applications are listed in Table 4 . It is worth noting that, according to a recent bibliometric study regarding the distribution of the biological applications of cyclodextrins, a significant share (around 20%) of these items concern the antimicrobial activity, just behind the antioxidant activity [ 79 ].…”

Section: Incorporation Of Active Substances In Polymeric Matrix Composites For Active Packaging Applicationsmentioning

confidence: 99%

Cyclodextrins in Polymer-Based Active Food Packaging: A Fresh Look at Nontoxic, Biodegradable, and Sustainable Technology Trends

et al. 2021

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Using cyclodextrins (CDs) in packaging technologies helps volatile or bioactive molecules improve their solubility, to guarantee the homogeneous distribution of the complexed molecules, protecting them from volatilization, oxidation, and temperature fluctuations when they are associated with polymeric matrices. This technology is also suitable for the controlled release of active substances and allows the exploration of their association with biodegradable polymer targeting to reduce the negative environmental impacts of food packaging. Here, we present a fresh look at the current status of and future prospects regarding the different strategies used to associate cyclodextrins and their derivatives with polymeric matrices to fabricate sustainable and biodegradable active food packaging (AFP). Particular attention is paid to the materials and the fabrication technologies available to date. In addition, the use of cutting-edge strategies, including the trend of nanotechnologies in active food packaging, is emphasized. Furthermore, a critical view on the risks to human health and the associated updated legislation is provided. Some of the more representative patents and commercial products that currently use AFP are also listed. Finally, the current and future research challenges which must be addressed are discussed.

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Cyclodextrin Monomers and Polymers for Drug Activity Enhancement

Cited by 32 publications

References 174 publications

Advances and Classification of Cyclodextrin-Based Polymers for Food-Related Issues

Advances and Classification of Cyclodextrin-Based Polymers for Food-Related Issues

Cyclodextrins as Anti-inflammatory Agents: Basis, Drugs and Perspectives

Cyclodextrins in Polymer-Based Active Food Packaging: A Fresh Look at Nontoxic, Biodegradable, and Sustainable Technology Trends

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