Cyclodextrin-Mediated Drug Release from Liposomes Dispersed Within a Bioadhesive Gel

Abstract

is able to mediate, within a bioadhesive hydrogel, the release of a liposome-encapsulated molecule allowing further application of this delivery system for mucosal administration.

Characterization and Release Studies of Liposomal Gels Containing Glutathione/Cyclodextrins Complexes Potentially Useful for Cutaneous Administration

“…In detail, the release profiles observed follow this trend: GSH liposomes < GSH/CH 3 -$-CD liposomes ≈ GSH/HP-$-CD liposomes. This result is in agreement with the role of CDs in destabilizing the liposomal bilayer by extraction of Chol and phospholipids 25 and this destabilizing effect entails a greater release of GSH within 24 h by liposomes containing complexes with CDs compared with liposomes containing GSH alone (8.18 ± 1.9% for GSH liposomes compared with 19.2 ± 1.0% and 17.30 ± 0.8% for liposomes containing the complex GSH/HP-$-CD and GSH/CH 3 -$-CD, respectively).…”

The effect of added liposomes on the rheological properties of a hydrogel: A systematic study

“…However is some studies in which charged liposomes were tested, some effects were demonstrated, as in the case of positively charged liposomes loaded (at 10 mM) in carbopol 974 P NF gel, which increased the gel viscosity. This effect was attributed to the cationic charge of the liposomes [23]. Additionally, negatively-charged liposomes were found to decrease the gelation rate and gel strength of thermosensitive chitosanbased hydrogels [24].…”

A Hybrid Hydrogel Biomaterial by Nanogel Engineering: Bottom‐Up Design with Nanogel and Liposome Building Blocks to Develop a Multidrug Delivery System

“…[ 1 , 2 ] In these systems, the controlled release of the scaffold molecules is particularly important because the tissue regeneration is dependent on the presence of an appropriate amounts of growth factors, the concentrations of which show temporal and spatial gradients. [ 2 ] For nanogels, [ 20 , 21 ] and liposomes [22][23][24][25][26] have already been proposed for use in implanted drug delivery systems and as tissue-engineering scaffolds. However, precise temporal and spatial control of drug delivery is a challenging issue.…”