Cyclodextrin-functionalized biomaterials loaded with miconazole prevent Candida albicans biofilm formation in vitro

Nava-Ortíz, Cesar A.B.; Burillo, Guillermina; Concheiro, Angel; Bucio, Emilio; Matthijs, Nele; Nelis, Hans; Coenye, Tom; Álvarez-Lorenzo, Carmen

doi:10.1016/j.actbio.2009.10.039

Cited by 57 publications

(43 citation statements)

References 48 publications

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“…Furthermore, they state that bacterial cell wall structures are likely to very much affect the viability [162] and this should be accounted for in future studies which are likely to investigate bacterial cell-substrate interactions. Whilst Terada and coworkers [161,162] showed that radiation grafting gave rise to an increase in bacterial adhesion, this is contrasted by Nava-Ortiz et al [164] who showed that Candida albicans adhesion can be reduced, preventing the formation of a biofilm on polyethylene (PE) and polypropylene (PP). It should be noted that Candida albicans is a fungus which, although forms a biofilm, has a very different adhesion and growth mechanism when compared to other forms of bacteria.…”

Section: Radiation Graftingmentioning

confidence: 45%

“…In addition, they carried out in vivo studies to AAm and HEMA grafted EPR, showing that CO 2 laser grafting can be employed to enhance the bioactivity of EPR [160]. Radiation grafting has been applied for the development of surfaces for the scientific study and control of bacterial adhesion and growth [34,[161][162][163][164][165][166]. The works of Terada and coworkers [161,162] showed how grafting diethlamine (DEA), ethylamino (EA) and sodium sulphite (SS) onto polymeric surfaces can manipulate bacterial adhesion and viability.…”

Section: Radiation Graftingmentioning

confidence: 99%

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Surface Treatments to Modulate Bioadhesion: A Critical Review

Waugh¹,

Toccaceli²,

Gillett³

et al. 2016

rev adhes adhesives

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On account of the recent increase in importance of biological and microbiological adhesion in industries such as healthcare and food manufacturing many researchers are now turning to the study of materials, wettability and adhesion to develop the technology within these industries further. This is highly significant as the stem cell industry alone, for example, is currently worth £3.5 million in the United Kingdom (UK) alone. This paper reviews the current state-of-the-art techniques used for surface treatment with regards to modulating biological adhesion including laser surface treatment, plasma treatment, micro/nano printing and lithography, specifically highlighting areas of interest for further consideration by the scientific community. What is more, this review discusses the advantages and disadvantages of the current techniques enabling the assessment of the most attractive means for modulating biological adhesion, taking in to account cost effectiveness, complexity of equipment and capabilities for processing and analysis.

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Section: Radiation Graftingmentioning

confidence: 45%

Section: Radiation Graftingmentioning

confidence: 99%

Surface Treatments to Modulate Bioadhesion: A Critical Review

Waugh¹,

Toccaceli²,

Gillett³

et al. 2016

rev adhes adhesives

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show abstract

“…[2][3][4] For fungal biofilms, Candida albicans (C. albicans) is the most prevalent. 5 Once the biofilms are established, they can be very difficult to treat with conventional antibiotic treatments since the bacteria in the biofilm are metabolically inactive, rendering the biofilms less responsive to antibiotics. [6][7][8] Under these circumstances, the infected device often fails and must be removed from the patient to eradicate the infection.…”

Section: Introductionmentioning

confidence: 99%

“…1 Many of the coatings rely on the encapsulation of various antibiotics or antifungal drugs to prevent device infection by locally delivering the drug. 5, While there are many benefits to locally delivering the drug to prevent device infection, these coatings have the potential to cause offtarget long-term toxicities, and can lead to the development of drug-resistant bacteria when the antibiotic is delivered at a subinhibitory dose and has a limited window of activity. 35 In an effort to extend the duration of the release and enhance the loading of the encapsulated drugs beyond that capable of ordinary polymers, many coatings have started to incorporate high-affinity moieties such as cyclodextrin (CD).…”

Section: Introductionmentioning

confidence: 99%

Emerging technologies for long-term antimicrobial device coatings: advantages and limitations

Cyphert

Recum

2017

Exp Biol Med (Maywood)

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This work provides an overview, with advantages and limitations of the most recently developed antibacterial coating technologies, enabling other researchers in the field to more easily determine which technology is most advantageous for them to further develop and pursue. AbstractOver the past 20 years, the field of antimicrobial medical device coatings has expanded nearly 30-fold with technologies shifting their focus from diffusion-only based (short-term antimicrobial eluting) coatings to long-term antimicrobial eluting and intrinsically antimicrobial functioning materials. A variety of emergent coatings have been developed with the goal of achieving long-term antimicrobial activity in order to mitigate the risk of implanted device failure. Specifically, the coatings can be grouped into two categories: those that use antibiotics in conjunction with a polymer coating and those that rely on the intrinsic properties of the material to kill or repel bacteria that come into contact with the surface. This review covers both long-term drug-eluting and non-eluting coatings and evaluates the inherent advantages and disadvantages of each type while providing an overview of variety applications that the coatings have been utilized in.

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“…Nava-Ortiz et al 206 used medical devices designed from polyethylene and polypropylene functionalized with HP-β-CD and β-CD to incorporate miconazole (MICO). Since the drug MICO is insoluble in water, CDs serve as an efficient option to assist the solubilization, thereby providing adequate bioavailability.…”

mentioning

confidence: 99%

Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

Ramos¹,

Silva²,

Spósito³

et al. 2018

IJN

216

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Since the dawn of civilization, it has been understood that pathogenic microorganisms cause infectious conditions in humans, which at times, may prove fatal. Among the different virulent properties of microorganisms is their ability to form biofilms, which has been directly related to the development of chronic infections with increased disease severity. A problem in the elimination of such complex structures (biofilms) is resistance to the drugs that are currently used in clinical practice, and therefore, it becomes imperative to search for new compounds that have anti-biofilm activity. In this context, nanotechnology provides secure platforms for targeted delivery of drugs to treat numerous microbial infections that are caused by biofilms. Among the many applications of such nanotechnology-based drug delivery systems is their ability to enhance the bioactive potential of therapeutic agents. The present study reports the use of important nanoparticles, such as liposomes, microemulsions, cyclodextrins, solid lipid nanoparticles, polymeric nanoparticles, and metallic nanoparticles, in controlling microbial biofilms by targeted drug delivery. Such utilization of these nanosystems has led to a better understanding of their applications and their role in combating biofilms.

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Cyclodextrin-functionalized biomaterials loaded with miconazole prevent Candida albicans biofilm formation in vitro

Cited by 57 publications

References 48 publications

Surface Treatments to Modulate Bioadhesion: A Critical Review

Surface Treatments to Modulate Bioadhesion: A Critical Review

Emerging technologies for long-term antimicrobial device coatings: advantages and limitations

Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

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