Cyclodextrin-derived pH-responsive nanoparticles for delivery of paclitaxel

He, Hongmei; Chen, Sha; Zhou, Jiahui; Ding, Yin; Liu, Song; Che, Ling; Zhou, Xing; Chen, Xin; Jia, Yong; Zhang, Jianxiang; Li, Shuhui; Li, Xiaohui

doi:10.1016/j.biomaterials.2013.03.068

Cited by 136 publications

(99 citation statements)

References 59 publications

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“…Anti-death receptor 5 anti-EGFR Anti-epidermal growth factor receptor anti-EpCAM Anti-epithelial cell adhesion molecule anti-HER2 Anti-human epidermal growth factor receptor 2 APO- He et al [35] Combination with montmorillonite Trastuzumab Sun et al [76] Block copolymer with poly (ethylene glycol) (PEG)…”

Section: -Aagmentioning

confidence: 99%

Advanced Engineering Approaches in the Development of PLGA-Based Nanomedicines

El-Hammadi¹,

Arias²

2015

Handbook of Nanoparticles

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Drug molecules often display little affinity for nonhealthy tissues and/or cells, leading to inefficiency, and high incidence of severe side effects. To face the problem, numerous strategies have been postulated, i.e., chemical modifications to the drug molecule, and proper engineering of drug nanocarriers. In this line, the introduction of poly(D,L-lactide-co-glycolide) nanoparticles in the drug delivery arena has been hypothesized to optimize drug biodistribution and concentration into the targeted site, thus improving the therapeutic effect while reducing the associated drug toxicity. Recent advances in the field have been devoted to the optimization of the in vivo fate and effectiveness of poly(D,L-lactide-co-glycolide)-based drug nanocarriers, i.e., by passive targeting strategies based on the functionalization of the particle surface with special biomolecules, and/or active targeting stratagems thanks to modifications leading to stimuliresponsive nanoparticles. In this chapter, we analyze the current state of the art and future perspectives in the formulation of poly(D,L-lactide-co-glycolide)-based nanomedicines against severe diseases.

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Section: -Aagmentioning

confidence: 99%

Advanced Engineering Approaches in the Development of PLGA-Based Nanomedicines

El-Hammadi¹,

Arias²

2015

Handbook of Nanoparticles

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“…Free DOX can be quickly transported into the cells by passive diffusion through the plasma membrane and can enter the active site, 50,51 while the drug-loaded metal-TA-coated NPs traversed the plasma membrane through endocytosis, which was much slower than passive diffusion. 52,53 The half maximal inhibitory concentration (IC 50 ) was also used to evaluate the antitumor activities. For HepG2 cells, the IC 50 of DOX-NPs was 2.36±0.18 μg/mL, while those for DOX-NPs-TA/Cu 1 2+ and DOX-NPs-TA/ Ca 2+ were 2.91±0.12 μg/mL and 2.67±0.28 μg/mL, respectively (Table S8).…”

Section: In Vitro Cytotoxicity Studymentioning

confidence: 99%

Tailoring stimuli-responsive delivery system driven by metal–ligand coordination bonding

Liang¹,

Zhou²,

He³

et al. 2017

IJN

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In this study, a novel coordination bonding system based on metal–tannic acid (TA) architecture on zein/carboxymethyl chitosan (CMCS) nanoparticles (NPs) was investigated for the pH-responsive drug delivery. CMCS has been reported to coat on zein NPs as delivery vehicles for drugs or nutrients in previous studies. The cleavage of either the “metal–TA” or “NH 2 –metal” coordination bonds resulted in significant release of guest molecules with high stimulus sensitivity, especially in mild acidic conditions. The prepared metal–TA-coated zein/CMCS NPs (zein/CMCS-TA/metal NPs) could maintain particle size in cell culture medium at 37°C, demonstrating good stability compared with zein/CMCS NPs. In vitro release behavior of doxorubicin hydrochloride (DOX)-loaded metal–TA film-coated zein/CMCS NPs (DOX-zein/CMCS-TA/metal NPs) showed fine pH responsiveness tailored by the ratio of zein to CMCS as well as the metal species and feeding concentrations. The blank zein/CMCS-TA/metal NPs (NPs-TA/metal) were of low cytotoxicity, while a high cytotoxic activity of DOX-zein/CMCS-TA/metal NPs (DOX-NPs-TA/metal) against HepG2 cells was demonstrated by in vitro cell assay. Confocal laser scanning microscopy (CLSM) and flow cytometry were combined to study the uptake efficiency of DOX-NPs or DOX-NPs-TA/metal. This system showed significant potential as a highly versatile and potent platform for drug delivery.

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“…Calculated by the following formula (eqn (1)), the fixed drug loading content was about 6.31 wt%, which was superior to the traditional drug delivery systems with the disadvantage of drug loading contents varying from batch to batch. 34 …”

Section: Polymer Chemistry Papermentioning

confidence: 99%

“…33 Furthermore, cyclodextrins can form inclusion complexes with various types of guest molecules such as azobenzene (AZO), ferrocene (Fc) and adamantine (ADA), which could be reversibly dissociated by external stimuli including thermodynamic processes, pH, redox agents or voltage, light, and chemical molecules. 28,[34][35][36][37][38] However, as far as we know, CD-based pH and glutathione dual tumor microenvironment triggered micelles with an anticancer drug as a hydrophobic component have not yet been reported. The difference in the redox potential environments of intra-and extracellular spaces could offer a chance for the programmed delivery of genes and drugs.…”

Section: Introductionmentioning

confidence: 99%

pH and glutathione dual-triggered supramolecular assemblies as synergistic and controlled drug release carriers

et al. 2017

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A pH and glutathione (GSH) dual bio-relevant triggered supramolecular system is constructed through the non-covalent host-guest interactions between the adamantane (ADA) on camptothecin (CPT) and β-cyclodextrin (β-CD) on the side chain of the backbone of hyaluronic acid (HA). The obtained noncovalent supramolecular β-CD-g-OX-HA/ADA-CPT complex could further self-assemble into a stable uniform sphere micellar structure with constant drug loading content in the extracellular environment but is cleaved in the cytosol of the cancer cells due to the acidic environment and the presence of a high concentration of GSH, resulting in a synergistic-fast pH and GSH triggered drug releasing behavior. The cytotoxicity of the supramolecular β-CD-g-OX-HA/ADA-CPT micelles was investigated using Hep G2 cancer cells by MTT assays, which displayed that supramolecular β-CD-g-OX-HA/ADA-CPT micelles had exhibited enhanced cellular proliferation inhibition against Hep G2 cancer cells compared to the free CPT, while the β-CD-g-OX-HA had good cell compatibility. In vivo studies of the β-CD-g-OX-HA/ADA-CPT micelles showed a higher in vivo efficacy without side effects and also confirmed the compatibility of the β-CD-g-OX-HA. It is anticipated that this supramolecular complex will give the possibility to fabricate new types of bio-relevant triggered nanocarriers for cancer therapy.

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Cyclodextrin-derived pH-responsive nanoparticles for delivery of paclitaxel

Cited by 136 publications

References 59 publications

Advanced Engineering Approaches in the Development of PLGA-Based Nanomedicines

Advanced Engineering Approaches in the Development of PLGA-Based Nanomedicines

Tailoring stimuli-responsive delivery system driven by metal–ligand coordination bonding

pH and glutathione dual-triggered supramolecular assemblies as synergistic and controlled drug release carriers

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Cyclodextrin-derived pH-responsive nanoparticles for delivery of paclitaxel

Cited by 136 publications

References 59 publications

Advanced Engineering Approaches in the Development of PLGA-Based Nanomedicines

Advanced Engineering Approaches in the Development of PLGA-Based Nanomedicines

Tailoring stimuli-responsive delivery system driven by metal&ndash;ligand coordination bonding

pH and glutathione dual-triggered supramolecular assemblies as synergistic and controlled drug release carriers

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Tailoring stimuli-responsive delivery system driven by metal–ligand coordination bonding