Cyclodextrin-Derived Drug Delivery Systems in Respiratory Diseases

Kumar, V.; Halder, Jitu; Rajwar, Tushar Kanti; Chawla, Goutam Rath Viney; Chawla, Pooja A.

doi:10.1007/978-981-19-7656-8_7

Cited by 2 publications

(1 citation statement)

References 50 publications

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“…It is also a major challenge for pharmaceutical companies in developing new medicines, as drug solubility in the CDDSs tends to be low, hence affecting efficacy. Moreover, low drug stability is one of the major limitations of using conventional pharmaceutical agents, as the CDDSs in some dosage forms are not sufficient in protecting the active pharmaceutical ingredients against biological fluids in the body and microenvironments [ 232 , 233 ]. However, with the current oral dosage forms developed to improve oral drug delivery, one aspect that is gaining attention is the exploration of gastro-retentive drug delivery systems (GRDDSs).…”

Section: Currents Trends and Gapsmentioning

confidence: 99%

Leading Paediatric Infectious Diseases—Current Trends, Gaps, and Future Prospects in Oral Pharmacotherapeutic Interventions

Rampedi,

Ogunrombi,

Adeleke

2024

Pharmaceutics

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Paediatric infectious diseases contribute significantly to global health challenges. Conventional therapeutic interventions are not always suitable for children, as they are regularly accompanied with long-standing disadvantages that negatively impact efficacy, thus necessitating the need for effective and child-friendly pharmacotherapeutic interventions. Recent advancements in drug delivery technologies, particularly oral formulations, have shown tremendous progress in enhancing the effectiveness of paediatric medicines. Generally, these delivery methods target, and address challenges associated with palatability, dosing accuracy, stability, bioavailability, patient compliance, and caregiver convenience, which are important factors that can influence successful treatment outcomes in children. Some of the emerging trends include moving away from creating liquid delivery systems to developing oral solid formulations, with the most explored being orodispersible tablets, multiparticulate dosage forms using film-coating technologies, and chewable drug products. Other ongoing innovations include gastro-retentive, 3D-printed, nipple-shield, milk-based, and nanoparticulate (e.g., lipid-, polymeric-based templates) drug delivery systems, possessing the potential to improve therapeutic effectiveness, age appropriateness, pharmacokinetics, and safety profiles as they relate to the paediatric population. This manuscript therefore highlights the evolving landscape of oral pharmacotherapeutic interventions for leading paediatric infectious diseases, crediting the role of innovative drug delivery technologies. By focusing on the current trends, pointing out gaps, and identifying future possibilities, this review aims to contribute towards ongoing efforts directed at improving paediatric health outcomes associated with the management of these infectious ailments through accessible and efficacious drug treatments.

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Section: Currents Trends and Gapsmentioning

confidence: 99%

Leading Paediatric Infectious Diseases—Current Trends, Gaps, and Future Prospects in Oral Pharmacotherapeutic Interventions

Rampedi,

Ogunrombi,

Adeleke

2024

Pharmaceutics

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Synthesis and Biological Evaluation of Gastroprotective Polymer Conjugates of Aceclofenac

Mishra,

Chawla,

Chawla

2024

COC

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Nonsteroidal anti-inflammatory drugs account for a sizeable fraction of the drugs prescribed worldwide. If consumed for a long time, they can cause ulcers and life-threatening side effects. Since the acidic group present in NSAIDs is mainly responsible for these side effects, the scientists try to synthesize polymer drug conjugates that avoid these side effects but still retain the potency of the parent drug. Macromolecular drug conjugates of aceclofenac were prepared by employing pectin, β cyclodextrin, deacetylated chitin (chitosan) and albumin (egg and bovine serum). The prepared conjugates were characterized and tested for their antiinflammatory, antinociceptive and antiulcerogenic activity. Further experimentation was undertaken to analyze the behavior of compounds and their stability in hydrolytic conditions. Test compound A1, a pectin conjugate of aceclofenac, exhibited significant antinociceptive and anti-inflammatory activity with a significant decrease in ulcer index (4.45±0.24) as against aceclofenac (8.61±0.40) or vehicle (12.39±0.44) treated group. A novel and safer polymer drug conjugate of aceclofenac has been synthesized and evaluated.

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Cyclodextrin-Derived Drug Delivery Systems in Respiratory Diseases

Cited by 2 publications

References 50 publications

Leading Paediatric Infectious Diseases—Current Trends, Gaps, and Future Prospects in Oral Pharmacotherapeutic Interventions

Leading Paediatric Infectious Diseases—Current Trends, Gaps, and Future Prospects in Oral Pharmacotherapeutic Interventions

Synthesis and Biological Evaluation of Gastroprotective Polymer Conjugates of Aceclofenac

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