Cyclodextrin-Based Optosensor for the Determination of Warfarin in Waters

Badía, R.; Dı́az-Garcı́a, Marta Elena

doi:10.1021/jf981330u

Cited by 24 publications

(9 citation statements)

References 26 publications

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“…A flow-through optosensor for warfarin is described [97]. The sensor is developed in conjunction with flow analysis systems and uses a commercial bound β-cyclodextrin material as the sensing phase.…”

Section: Fluorescencementioning

confidence: 99%

Recent Development in Optical Chemical Sensors Coupling with Flow Injection Analysis

Ojeda

Rojas

2006

Sensors

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Abstract:Optical techniques for chemical analysis are well established and sensors based on these techniques are now attracting considerable attention because of their importance in applications such as environmental monitoring, biomedical sensing, and industrial process control. On the other hand, flow injection analysis (FIA) is advisable for the rapid analysis of microliter volume samples and can be interfaced directly to the chemical process. The FIA has become a widespread automatic analytical method for more reasons; mainly due to the simplicity and low cost of the setups, their versatility, and ease of assembling. In this paper, an overview of flow injection determinations by using optical chemical sensors is provided, and instrumentation, sensor design, and applications are discussed. This work summarizes the most relevant manuscripts from 1980 to date referred to analysis using optical chemical sensors in FIA.

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Section: Fluorescencementioning

confidence: 99%

Recent Development in Optical Chemical Sensors Coupling with Flow Injection Analysis

Ojeda

Rojas

2006

Sensors

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“…[13][14][15] Driven by hydrophobic interactions, small molecules, including warfarin, tend to bind to b-cyclodextrin (b-CD), which has a Correspondence concerning this article should be addressed to V. I. Vullev at vullev@ucr.edu. Scheme 2).…”

Section: Introductionmentioning

confidence: 99%

Fluorescence enhancement of warfarin induced by interaction with β‐cyclodextrin

Vasquez

Schultz

et al. 2009

Biotechnology Progress

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Warfarin is the most common agent used for control and prevention of venous as well as arterial thromboembolism (blood clots). In aqueous media, warfarin forms inclusion complexes with a family of cyclic oligosaccharides, alpha, beta, gamma-cyclodextrins (CD). The formation of these complexes results in enhancement of the fluorescence of warfarin. Such spectroscopic changes offer a venue for the development of bioanalytical methodologies for warfarin quantification in biological liquids. We characterized the photophysical properties of warfarin in solvents with varying polarity and viscosity. The fluorescence quantum yield of warfarin correlated: (1) strongly with the solvent viscosity (R = 0.979) and (2) weakly with the solvent polarity (R = 0.118). These findings indicate that it is the change of the viscosity, rather than polarity, of the microenvironment that causes the fluorescence enhancement of warfarin upon binding to beta-CD. Utilizing the observed fluorescence enhancement in fluorescence titration measurements, the binding constants of warfarin to beta-CD were obtained (2.6 x 10(2) M(-1)-3.7 x 10(2) M(-1)). Using multivariable linear analysis, we extracted the stoichiometry of warfarin-beta-CD interaction (1:1).

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“…Such studies would become especially interesting once structures of vitamin K epoxide reductase become available. At the same time, the formation of inclusion complexes of warfarin with b-cyclodextrin is of technological importance, both in the context of chiral separations [44,45] and biosensing applications [46,47], but details of the molecular interactions between warfarin and b-cyclodextrin remain largely unknown.…”

Section: Discussionmentioning

confidence: 99%