Cyclodextrin-based nanosponges: a propitious platform for enhancing drug delivery

Chilajwar, Sai V; Pednekar, Priti; Jadhav, Kisan R.; Gupta, Gajendra J C; Kadam, Vilasrao J.

doi:10.1517/17425247.2014.865013

Cited by 96 publications

(73 citation statements)

References 29 publications

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“…21, 22 An example of the CL reagent used is pyromellitic anhydride (PMA). 21, 22 An example of the CL reagent used is pyromellitic anhydride (PMA).…”

Section: Introductionmentioning

confidence: 99%

Water and polymer dynamics in a model polysaccharide hydrogel: the role of hydrophobic/hydrophilic balance

Rossi

Venuti

D’Amico

et al. 2015

Phys. Chem. Chem. Phys.

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The molecular dynamics of water and a polymer matrix is here explored in a paradigmatic model of a polysaccharide hydrogel, by the combined use of UV Raman scattering and infrared measurements. The case example of cyclodextrin nanosponges (CDNS)/hydrogel is chosen since the simultaneous presence in the structure of the polymer matrix of both hydrophilic and hydrophobic sites mimics the complexity of polysaccharide hydrogels. In this way, the contributions provided by the balance between the hydrophilicity/hydrophobicity and the grade of entanglement of the polymer hydrogel to lead to the formation of the gel phase are separately accounted and evaluated. As main results, we found that the hydrophobic CH groups inserted on the aromatic ring of CDNS experience a more pronounced dynamic perturbation with respect to the carbonyl groups due to the collision between the solvent and vibrating atoms of the polymer. The overall results provide a detailed molecular picture of the swelling phenomena occurring when a chemically cross-linked polymer contacts with water or biological fluids and exploits the potentiality of UV Raman spectroscopy to retrieve dynamic information besides their structural counterpart obtained by the classical analysis of the basic features of vibrational spectra.

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“…21, 22 An example of the CL reagent used is pyromellitic anhydride (PMA). 21, 22 An example of the CL reagent used is pyromellitic anhydride (PMA).…”

Section: Introductionmentioning

confidence: 99%

Water and polymer dynamics in a model polysaccharide hydrogel: the role of hydrophobic/hydrophilic balance

Rossi

Venuti

D’Amico

et al. 2015

Phys. Chem. Chem. Phys.

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“…23,27,28 In particular, NS provide the advantage of an efficient tailoring of their structural and functional properties (e.g. hydrophobicity of chain side groups, degree of crosslinking and branches and mesh size of the gel network) by acting on specific factors during the synthesis of the polymer.…”

Section: Introductionmentioning

confidence: 99%

Toward an understanding of the thermosensitive behaviour of pH-responsive hydrogels based on cyclodextrins

et al. 2015

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The molecular mechanism responsible for the thermosensitive behaviour exhibited by pH-responsive cyclodextrin-based hydrogels is explored here with the twofold aim of clarifying some basic aspects of H-bond interactions in hydrogel phases and contributing to a future engineering of cyclodextrin hydrogels for targeted delivery and release of bioactive agents. The degree of H-bond association of water molecules entrapped in the gel network and the extent of intermolecular interactions involving the hydrophobic/ hydrophilic moieties of the polymer matrix are probed by UV Raman and IR experiments, in order to address the question of how these different and complementary aspects combine to determine the pH-dependent thermal activation exhibited by these hydrogels. Complementary vibrational spectroscopies are conveniently employed in this study with the aim of safely disentangling the spectral response arising from the two main components of the hydrogel systems, i.e. the polymer matrix and water solvent. The experimental evidence suggests that the dominant effects in the mechanism of solvation of cyclodextrin-based hydrogels are due to the changes occurring, upon increasing of temperature, in the hydrophobicity character of specific chemical moieties of the polymer, as triggered by pH variations. The achievements of this work corroborate the potentiality of the UV Raman scattering technique, in combination with more conventional IR experiments, to provide a ''molecular view'' of complex macroscopic phenomena exhibited in hydrogel phases.

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“…26 The polymer matrix of NSs has shown to be able to retain large fractions of water within its structure, affording homogeneous gel phases. 27 Besides their potential practical applications as nano-carriers of bioactive agents, 28,29 the study of the behaviour of water entrapped in NS hydrogels can provide new fundamental insights into the water-water and water-polymer interactions in soft confining systems. This is due to the simultaneous presence of hydrogen bond donor/acceptor groups in the polymer skeleton, as well as due to the presence of nano-spaces where water can be confined.…”

Section: Introductionmentioning

confidence: 99%

Vibrational signatures of the water behaviour upon confinement in nanoporous hydrogels

Rossi

Venuti

Punta

et al. 2016

Phys. Chem. Chem. Phys.

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The fundamental question of how the reorganization of the hydrogen-bond (HB) network of water is influenced by the combination of nano-confinement and hydrophobic/hydrophilic solvation effects is addressed here using a spectroscopic study of water absorbed in a model, pH-sensitive polysaccharide hydrogel. The effects of temperature, hydration level and pH on the vibrational dynamics associated with the water molecules and the polymer skeleton are disentangled and analysed by a complementary and combined use of UV-Raman scattering and IR spectroscopy. The experimental data give evidence that the solvation effects in the hydrogel matrix are essentially dominated by the hydration of more hydrophobic parts of the polymer network, while the effect of pH on the HB reorganization of confined water molecules is found to be similar to that induced by cooling of the system. A tentative explanation of these results has been provided in terms of interplay between different kinds of interactions, i.e. hydrophobic vs. hydrophilic.

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Cyclodextrin-based nanosponges: a propitious platform for enhancing drug delivery

Cited by 96 publications

References 29 publications

Water and polymer dynamics in a model polysaccharide hydrogel: the role of hydrophobic/hydrophilic balance

Water and polymer dynamics in a model polysaccharide hydrogel: the role of hydrophobic/hydrophilic balance

Toward an understanding of the thermosensitive behaviour of pH-responsive hydrogels based on cyclodextrins

Vibrational signatures of the water behaviour upon confinement in nanoporous hydrogels

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