Cyclodextrin-based dextromethorphan potentiometric sensors

Khaled, Elmorsy; Kamel, Manal S.; Hassan, H. N. A.; Aboul‐Enein, Hassan Y.

doi:10.1016/j.jelechem.2011.08.008

Cited by 19 publications

(8 citation statements)

References 39 publications

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“…7 In addition, the development of simple, rapid, sensitive, highly selective, and time-saving methods for the detection and quantication of one individual enantiomer in very complex samples containing a mixture of enantiomers still remains a challenge. 8,9 Although various techniques, such as UV-vis spectroscopy, 10 uorescence spectroscopy, 11 highperformance liquid chromatography, 12 capillary electrophoresis 13 and electrochemical investigations 14,15 have been performed for the detection of the enantiomers of different compounds, a few studies have been successfully carried out for the electrochemical discrimination of enantiomers. For instance, Kataky and Lopes have achieved the discrimination of facilitated chiral transfer of the ephedrinium ion at liquidliquid interface, 4 Nie et al have prepared cysteic acid modied glassy carbon electrodes to discriminate tyrosine enantiomers, 16 and Zor et al have developed an electrochemical biosensor based on the human serum albumin/graphene oxide/3-aminopropyltriethoxysilane modied indium tin oxide electrode for the discrimination of tryptophan enantiomers.…”

Section: Introductionmentioning

confidence: 99%

An electrochemical and computational study for discrimination ofd- andl-cystine by reduced graphene oxide/β-cyclodextrin

Zor

Bingöl

Ramanavičienė

et al. 2015

Analyst

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Here, we report a novel enantioselective electrochemical biosensor for the discrimination of cystine enantiomers (d- and l-cystine) using a chiral interface for the specific recognition of d- and l-cystine. The biosensor is based on reduced graphene oxide modified by β-cyclodextrin (rGO/β-CD) at the GCE surface. During the preparation of rGO/β-CD/GCE, the modified electrode surfaces were characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM). The electrochemical behaviours of the d- and l-cystine were investigated using the rGO/β-CD/GCE by CV and compared to bare GCE. A clear separation between the oxidation peak potentials of d- and l-cystine was observed at 1.32 and 1.42 V, respectively. The electrochemical discrimination performance of the fabricated chiral sensor was also examined by differential pulse voltammetry (DPV) in a mixed solution of d- and l-cystine. In addition, the DPV technique was used for the determination of d- and l-cystine at low concentration values in the range of 1.0-10.0 μM. To investigate the amperometric response of rGO/β-CD/GCE towards d- and l-cystine, the chronoamperometry technique was used in the concentration range of 10.0-100.0 μM. The interactions of the enantiomers with rGO/β-CD were modelled by molecular docking using AutoDock Vina, and the interaction energies were predicted to be -4.8 and -5.3 kcal mol(-1) for d- and l-cystine, respectively. The corresponding values of binding constants were calculated to be 3.32 × 10(3) and 7.71 × 10(3) M(-1), respectively. The experimental and molecular docking results indicate that the rGO/β-CD/GCE has a different affinity for each enantiomer.

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Section: Introductionmentioning

confidence: 99%

An electrochemical and computational study for discrimination ofd- andl-cystine by reduced graphene oxide/β-cyclodextrin

Zor

Bingöl

Ramanavičienė

et al. 2015

Analyst

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“…[88] Potentiometric DCL studies concerning the use of cyclodextrins as ionophores were also described. [21,[89][90][91][92][93][94] Lenik [21] reported the preparation of such DCL-selective membrane electrode incorporating heptakis(2,3,6-tri-O-benzoyl) -β-cyclodextrin, plasticized with 2-nitrophenyloctyl ether, with a limit of detection of 14 μmol L À 1 .…”

Section: Potentiometric Methodsmentioning

confidence: 99%

Input of Electroanalytical Methods for the Determination of Diclofenac: A Review of Recent Trends and Developments

et al. 2021

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Diclofenac (DCL) is a nonsteroidal anti-inflammatory commonly prescribed to treat inflammatory joint diseases and mild to moderate pain. DCL residues have often been detected in freshwater environments and it belongs to the list of emerging pollutants (EPs) because of the risk it presents for health and environment. Many studies have described the potential effects of DCL on organisms when exposed to environmental levels ranging from a few ng L À 1 to tens of μg L À 1 in surface water. Until now, its detection essentially depends on conventional techniques, such HPLC and GC/MS. Although these analytic techniques are very robust, they are expensive, require experts, and are not portable. Electrochemical sensors are an attractive alternative. They provide many benefits over thermal, optical, and piezoelectric detection including ease of use, rapidity, costeffectiveness, high sensitivity and selectivity, ease of miniaturization and robustness. The aim of this review is to report electrochemical methods used for the detection of DCL and to describe strategies for improving performances of each sensors.

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“…The response of ionophore-based potentiometric sensors is usually governed by the molecular recognition ability between the analyte (guest) and the host molecule [27].…”

Section: Ionophoresmentioning

confidence: 99%

“…Efforts to improve ion-selective electrode characteristics were proposed, and the proposals include species capable of molecular recognition [14][15][16][17][18][19][20][21][22][23][24][25][26][27]. For this reason, different types of ionophores such as 2-hydroxypropyl-ȕ-cyclodextrin (2-HP ȕCD) and 4-tertbutylcalix [8]arene (tBC8) were implemented in this study.…”

Section: Introductionmentioning

confidence: 99%

Novel potentiometric application for the determination of pantoprazole sodium and itopride hydrochloride in their pure and combined dosage form

Ragab

El-Rahman

Ramadan

et al. 2015

Talanta

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Cyclodextrin-based dextromethorphan potentiometric sensors

Cited by 19 publications

References 39 publications

An electrochemical and computational study for discrimination ofd- andl-cystine by reduced graphene oxide/β-cyclodextrin

An electrochemical and computational study for discrimination ofd- andl-cystine by reduced graphene oxide/β-cyclodextrin

Input of Electroanalytical Methods for the Determination of Diclofenac: A Review of Recent Trends and Developments

Novel potentiometric application for the determination of pantoprazole sodium and itopride hydrochloride in their pure and combined dosage form

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