Cyclodextrin-based dendritic supramolecules; new multivalent nanocarriers

Abstract

Multiarm star copolymers containing a b-cyclodextrin core and poly(2-ethyl-2-oxazoline) arms (CD-POX) were synthesized and characterized. Synthesized CD-POX star copolymers were able to form supramolecular dendritic polymers (SDPs) in aqueous solutions. The ability of SDPs to encapsulate and transfer small guest molecules and also metal nanoparticles was investigated.

Supramolecular control over thermoresponsive polymers

“…Similarly as with other copolymer architectures, the assembly/disassembly of the hyperbranched structures can be controlled by the addition of a competitive guest [78][79][80], or other stimuli [81,82], making these responsive supramolecular systems of interest for the development of, for example, drug/gene delivery carriers.…”

Design Strategies for Functionalized Poly(2-oxazoline)s and Derived Materials

“…Adeli and co-workers reported on the synthesis and characterization of multiarm star copolymers consisting of a β-cyclodextrin core with pEtOx arms [120]. β-Cyclodextrin was reacted with iodine and triphenyl phosphine (substitution of the primary OH groups by iodine) in order to yield a heptavalent cyclodextrin macroinitiator that initiated the CROP of EtOx.…”

Supramolecular cyclodextrin-based drug nanocarriers

“…9 More recently, the design of novel systems in which the CDs act cooperatively to further exploit the host-guest interactions, mimicking the relatively weak but redundant interactions of molecular recognition in Nature, is opening an unexpectedly wide range of 35 advanced applications. [10][11][12][13] CDs are a group of cyclic oligosaccharides obtained from enzymatic processing of starch with a torus-like molecular shape. These cyclic oligosaccharides containing six (αCD), seven (βCD), eight (γCD), or more (α-1,4-)-linked D-glucopyranose 40 units, consist of a relatively hydrophobic inner cavity and a hydrophilic outer face.…”

“…17,31 Incorporation of CDs to nanostructured networks may result in carriers that exhibit distinct hydrophobic/hydrophilic domains useful for hosting water-soluble or insoluble drugs. 32-34 10 CDs have been found to form inclusion complexes not only with low molecular weight drugs, but also with macromolecules. New molecular structures and functions have been obtained combining polymers and lipids with CDs (Fig.…”

“…CDs can also polymerize with other CDs or can be used to functionalize preexisting polymers to form polymers/networks with enhanced capability to form inclusion complexes. 10 Alternatively, CDs can be exploited as transient cross-linkers to form poly(pseudo)rotaxane-based networks or zipper-like assemblies. Combination of mutifunctionality and complexation ability of CDs has been shown useful to develop depot-like formulations and colloidal nanocarriers with improved performances regarding easiness of administration, protection of the encapsulated substances, control of the delivery rate, and cell interactions.…”