Cyclodextrin-based delivery systems for chemotherapeutic anticancer drugs: A review

Tian, Bingren; Hua, Shiyao; Liu, Jiayue

doi:10.1016/j.carbpol.2019.115805

Cited by 162 publications

(91 citation statements)

References 171 publications

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“…In fact, nanotechnological strategies have been employed to prepare formulations of several medications with increased pharmaceutical efficacy, and, consequently, safety. Nanocarrier systems can be used to formulate and vehiculate lipophilic chemotherapeutic agents [127] while improving their selectivity and therapeutic activity in vitro and in vivo [128][129][130][131]. Other benefits of nanoencapsulation include advantages such as (1) protection from degradation, (2) longer circulation time in the bloodstream, (3) enhanced bioavailability and cellular uptake, (4) vectorization to selected tissues, (5) prevention of efflux by multidrug resistance pumps, and (6) controlled release [132,133].…”

Section: Formulation Techniquesmentioning

confidence: 99%

Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents

et al. 2020

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Porphyrins and analogous macrocycles exhibit interesting photochemical, catalytic, and luminescence properties demonstrating high potential in the treatment of several diseases. Among them can be highlighted the possibility of application in photodynamic therapy and antimicrobial/antiparasitic PDT, for example, of malaria parasite. However, the low efficiency generally associated with their low solubility in water and bioavailability have precluded biomedical applications. Nanotechnology can provide efficient strategies to enhance bioavailability and incorporate targeted delivery properties to conventional pharmaceuticals, enhancing the effectiveness and reducing the toxicity, thus improving the adhesion to the treatment. In this way, those limitations can be overcome by using two main strategies: (1) Incorporation of hydrophilic substituents into the macrocycle ring while controlling the interaction with biological systems and (2) by including them in nanocarriers and delivery nanosystems. This review will focus on antiparasitic drugs based on porphyrin derivatives developed according to these two strategies, considering their vast and increasing applications befitting the multiple roles of these compounds in nature.

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Section: Formulation Techniquesmentioning

confidence: 99%

Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents

et al. 2020

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“…The complexes of these drugs with CDs could mask undesirable properties. CD carriers such as nanosystems (nanosponges, nanofibers, dendrimers, metallic nanoparticles, quantum dots, nanoemulsions), liposomes, micelles, micro rods, niosomes, and siRNA may hide the undesired characteristics of drugs, thus improving their bioavailability [61,62].…”

Section: Current Status Of Cyclodextrin Complexes In Pharmaceutical Amentioning

confidence: 99%

“…CD has been extensively applied in gene therapy, nanomedicine therapy, cell therapy, chemotherapy, and immunotherapy. Studies have shown that numerous anticancer drugs, with properties such as instability, lack of physicochemical properties, or poor water solubility, have limited application in pharmaceutical applications [62]. Also, α-CD and β-CD are not degraded by pancreatic amylases enzymes and human salivary.…”

Section: Current Status Of Cyclodextrin Complexes In Pharmaceutical Amentioning

confidence: 99%

An update on cyclodextrins as drug vehicles for antimicrobial applications

Bülbül¹,

Eleftherıadou²,

Okur³

et al. 2020

jpt

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Cyclodextrins belong to cyclic oligosaccharides comprised of α-(1,4) linked glucopyranose groups. Their interesting supramolecular cavity-like structure can host active molecules providing a breeding ground for drug delivery systems. Cyclodextrins, due to their unique functional structure, can produce host-guest complexes with active ingredients, such as drugs, peptides, proteins, etc.; the complexes resulted from intramolecular interactions leading to stable molecules vehicles. Moreover, cyclodextrins are already applied in pharmaceutical industry applications since they can induce the solubility of lipophilic compounds and provide bioavailability and excellent safety profile and stability. In this review, the basic background for cyclodextrins and their current applications in the antimicrobial field are discussed. Besides, the antibacterial and antifungal-applications in the pharmaceutical field attract most researchers because of microbes' resistance. Regarding this, the most recent cyclodextrin inclusion complexes with antimicrobial and antifungal drugs are summarized in this article.

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“…). CDs are mainly composed of six, seven or eight glucose units to form different cavity sizes and have been widely used for various applications . Because of the hydrophilic hydroxyl groups, the outer portions of these cyclic molecules are rendered hydrophilic.…”

Section: Introductionmentioning

confidence: 99%

The application and prospects of cyclodextrin inclusion complexes and polymers in the food industry: a review

Tian

Xiao

Hei

et al. 2020

Polymer International

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Cyclodextrin is an odorless and tasteless cyclic oligosaccharide widely used in various fields such as food, medicine and the environment. Cyclodextrin can improve solubility and stability, and can mask the bad taste of specific substances. Cyclodextrins and their polymers primarily act by forming complexes in foods, and can be applied in food packing, food analysis, enhancing the properties of antioxidants, antibacterials, for stability and so on. The challenges and opportunities facing this area are reviewed. It is hoped that the review will provide useful information for future applications of cyclodextrin in the food industry.

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Cyclodextrin-based delivery systems for chemotherapeutic anticancer drugs: A review

Cited by 162 publications

References 171 publications

Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents

Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents

An update on cyclodextrins as drug vehicles for antimicrobial applications

The application and prospects of cyclodextrin inclusion complexes and polymers in the food industry: a review

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