Cyclodextrin-based controlled drug release system

Hirayama, Fumitoshi

doi:10.1016/s0169-409x(98)00058-1

Cited by 436 publications

(206 citation statements)

References 80 publications

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“…In total, 3.0Â10 5 HeLa cells were seeded on the glass coverslip in a six-well plate. After 20 h of incubation, the medium was changed to Hanks' balanced salt solution containing the copolymer (1 mg ml À1 , 2 ml per well), and the cells were incubated for 1 or 3 h. Subsequently, the cells were fixed by adding cold methanol and were stained with wheat germ agglutinin-Alexa 647 (5 mg ml À1 , 2 ml per well, 10 min at room temperature) and propidium iodide (0.25 mg ml À1 , 1 ml per well, 5 min of incubation).…”

Section: Confocal Fluorescence Microscopymentioning

confidence: 99%

“…In particular, drug targeting has progressed significantly, and many techniques based on the targeting of specific regions have been realized. [2][3][4][5][6][7][8] In addition, many carriers that distribute drugs in the cell nucleus have been reported. [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] However, reports on DDSs that target specific organelles other than the nucleus are scarce.…”

Section: Introductionmentioning

confidence: 99%

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Physicochemical delivery of amphiphilic copolymers to specific organelles

Kojima

Kasuya

Ishihara

et al. 2011

Polym J

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In this study, a novel polymer material was introduced into cells and was delivered to specific organelles. Various fluorescently labeled copolymers of 2-methacryloyloxyethylphosphorylcholine (MPC) and alkyl methacrylates, such as n-hexyl methacrylate (HMA), n-dodecyl methacrylate (DMA) and stearyl methacrylate (SMA), were synthesized. HeLa cells were treated with the copolymers and subsequently observed by confocal fluorescence microscopy. The results indicated that the localization behavior of the copolymers was dependent on their structure. For instance, poly(HMA-co-MPC) was non-cytotoxic and was localized in specific cellular organelles such as the endoplasmic reticulum. In contrast, poly(DMA-co-MPC) was cytotoxic and was partially transported to specific organelles. Poly(SMA-co-MPC) hardly entered the cells. The mechanism of delivery and structure-function relationships of the copolymers are also discussed.

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Section: Confocal Fluorescence Microscopymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physicochemical delivery of amphiphilic copolymers to specific organelles

Kojima

Kasuya

Ishihara

et al. 2011

Polym J

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“…These selectively modified CDs can keep the ability to complex with drug molecules while the "new" groups in 6 positions improve their properties greatly to meet the demands of being functionalized drug carriers. Many researchers have reported the synthesis of modified CDs which have potential utility in drug delivery [9][10][11][12][13]. One example is the β-CD conjugate with opioid peptide that may be used as brain target drug carrier [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…Many researchers have reported the synthesis of modified CDs which have potential utility in drug delivery [9][10][11][12][13]. One example is the β-CD conjugate with opioid peptide that may be used as brain target drug carrier [11,12]. Some neoglycoconjugates based on cyclodextrins also exhibit good biological recognizability [13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of hyperbranched poly (sulfone-amine) modified β-cyclodextrin

Chen

Jia

et al. 2006

E-Polymers

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An economical strategy to prepare hyperbranched poly(sulfone-amine) modified β-cyclodextrins (HPSA-m-CDs) from natural β-cyclodextrin (β-CD) and other commercially available materials has been reported. The final product has many good properties of hyperbranched poly(sulfone-amine)s (good solubility, low viscosity etc.), while its inclusion ability can also be well kept. It is a feasible approach to prepare functionalized modified cyclodextrin at very low cost, and may have potential applications in the fields of catalysis, drug delivery, food additives, etc.

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“…Cyclodextrins (CDs) are known to form inclusion complexes with lipophilic drugs as guest molecules and thus improve their water solubility. Furthermore the important characteristics of CDs are that they form inclusion complexes both in solution and in the solid state [5]. There are reports showing the improvement of pharmaceutical properties of CsA using formation of complexes with CD; a-CD improves the solubility of CsA in ophthalmic solutions [6], dimethyl (DM)-a-CD forms a complex with CsA and improves the oral absorption of CsA in rats [7], and CsA complexed with DM-b-CD results in increased solubility [8] and dissolution rate of CsA in the gastrointestinal tract [9].…”

mentioning

confidence: 99%

A cyclosporin A/maltosyl- -cyclodextrin complex for inhalation therapy of asthma

Fukaya¹,

Iimura²,

Hoshiko³

et al. 2003

European Respiratory Journal

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The inhalation of cyclosporin (Cs)A to the lung is limited by its hydrophobic properties. In order to improve the poor solubility of CsA, cyclodextrin (CD) was evaluated for its suitability for dry powder inhaler formation, and the benefit of an inhaled CsA/CD complex in vivo was demonstrated.The solubilising effect of CDs on CsA was measured by high-performance liquid chromatography. Ciliostatic activity and haemolysis were determined to assess some safety profiles of CDs. The efficacy of an inhaled CsA/CD complex was evaluated by eosinophil infiltration into the bronchoalveolar lavage fluid in actively sensitised mice.CDs markedly improved the poor solubility of CsA. The ciliostatic and haemolytic activities of maltosyl-a-CD were the weakest of all the tested CDs. CsA inhaled alone showed inhibitory effects on allergen-induced eosinophilia. Inhalation of the complex of CsA with maltosyl-a-CD, where the dose of CsA was approximately nine-times less than that of CsA inhaled alone, also inhibited eosinophil accumulation significantly, with a longer duration of action in comparison with the response to CsA alone.Thus the effective dose of cyclosporin A could be reduced by formation of a complex with maltosyl-a-cyclodextrin, and a wider therapeutic safety margin by inhalation of cyclosporin A as a complex with maltosyl-a-cyclodextrin could be expected. Eur Respir J 2003; 22: 213-219.

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Cyclodextrin-based controlled drug release system

Cited by 436 publications

References 80 publications

Physicochemical delivery of amphiphilic copolymers to specific organelles

Physicochemical delivery of amphiphilic copolymers to specific organelles

Synthesis and characterization of hyperbranched poly (sulfone-amine) modified β-cyclodextrin

A cyclosporin A/maltosyl- -cyclodextrin complex for inhalation therapy of asthma

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