Cyclodextrin/Adamantane-Grafted Polyethylene Glycol–Based Self-assembling Constructs for Topical Delivery of Ketorolac Tromethamine: Formulation, Characterization, and In Vivo Studies

Abdellatif, Ahmed A. H.; Mohammed, Ahmed M.; Zayed, Gamal; El-Rasoul, Saleh Abd; Almawash, Saud; Safwat, Mohamed; Osman, Shaaban K.

doi:10.1208/s12249-021-02188-3

Cited by 3 publications

(2 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…KT has been formulated as mucoadhesive hydrogels for pain management after pharmacotherapy. Ahmed A H Abdellatif et al., formulated cyclodextrin/adamantane-grafted polyethylene glycol-based self-assembling constructs for topical delivery of ketorolac tromethamine (Abdellatif et al., 2022 ). Yet another sustained and controlled systems of KT have been formulated into nanofibrils graft and polymer network hydrogels (Orasugh et al., 2019 ; Suhail et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Aldawsari

Naveen²,

Alhakamy

et al. 2022

Drug Delivery

View full text Add to dashboard Cite

Pulsatile drug delivery systems have drawn attention in contemporary research for designing chronotherapeutic systems. The current work aims to design pulsatile ketorolac tromethamine tablets using compression coating for delayed delivery with a lag time suitable for the treatment of morning stiffness in arthritis. Rapidly disintegrating core tablets of ketorolac tromethamine were formulated using super-disintegrants, and the optimized formulation was compression using PEO WSR coagulant and Eudragit RLPO for delaying the release. The central composite design and response surface methodology were employed to optimize the formulation and process parameters namely PEO WSR Coagulant (X 1 ), Eudragit RLPO (X 2 ), and Hardness (X 3 ). The dependent variables optimized were lag time and time required for 95% drug release. Analysis using response surface graphs and mathematical modeling of the results allowed identifying and quantifying the formulation variables active on the selected responses. A polynomial equation fitted to the data was used to predict the composition with optimum responses. Compression-coated pulsatile tablets’ optimized composition exhibited a lag time of 9 h and released 95% of the ketorolac tromethamine in 17.42 h. Validation of the mathematical model assured the reliability of QBD in formulation design. In vivo X-ray imaging and pharmacokinetic studies established a strong relationship between the coated polymers maintaining the desired lag time for delayed delivery of the active to coincide with the chronobiology for enhanced bioavailability at the right time when needed.

show abstract

Section: Introductionmentioning

confidence: 99%

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Aldawsari

Naveen²,

Alhakamy

et al. 2022

Drug Delivery

View full text Add to dashboard Cite

show abstract

“…There are different types of hydrogel, such as peptide and polymeric hydrogels. Due to their important properties like the biodegradability, biocompatibility, viscoelasticity and mucoadhesion, hydrogels became more interesse for the use as vehicles for vaccines [164] . The administration can be by spraying for mucosal immunization or by injection for parenteral immunization [165] , [166] , [167] .…”

Section: Other Advanced Vaccine Delivery Systemsmentioning

confidence: 99%

Vaccine delivery systems and administration routes: Advanced biotechnological techniques to improve the immunization efficacy

Bouazzaoui,

Abdellatif

2024

Vaccine: X

View full text Add to dashboard Cite

Stable operation of SiO anodes enabled by a multifunctional molecular crosslinker

Zheng,

Zhao,

Guo

et al. 2024

Journal of Power Sources

View full text Add to dashboard Cite

Cyclodextrin/Adamantane-Grafted Polyethylene Glycol–Based Self-assembling Constructs for Topical Delivery of Ketorolac Tromethamine: Formulation, Characterization, and In Vivo Studies

Cited by 3 publications

References 43 publications

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Vaccine delivery systems and administration routes: Advanced biotechnological techniques to improve the immunization efficacy

Stable operation of SiO anodes enabled by a multifunctional molecular crosslinker

Contact Info

Product

Resources

About