Cyclocarya paliurus leaves alleviate hyperuricemic nephropathy via modulation of purine metabolism, antiinflammation, and antifibrosis

Gui, Rui; Wang, Yikun; Wu, Jianping; Deng, Gui-Ming; Cheng, Fei; Zeng, Hongliang; Zeng, Puhua; Long, Hong-Ping; Zhang, Wei; Wei, Xi-Fan; Wang, Wen-Xuan; Zhu, Gangzhi; Chen, Zu-Hui; He, Xiaoai; Xu, Kang‐Ping

doi:10.1016/j.jff.2023.105485

Cited by 3 publications

(4 citation statements)

References 78 publications

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“…The possible pathways for TAP affecting PO-induced HUA were “neuroactive ligand–receptor interaction”, “purine metabolism”, “protein digestion and absorption”, “propanoate metabolism”, and “ABC transporters”, among which purine metabolism had the highest number of metabolites and the highest enrichment significance. It was suggested that TAP mainly regulated purine metabolism to alleviate HUA, corresponding to the previous results. ,, Besides, the difference abundance score map of the pathway (Figure B) also confirmed that the downregulation of purine metabolism and ABC transporters contributed to the effect of HUA.…”

Section: Resultssupporting

confidence: 84%

“…It was suggested that TAP mainly regulated purine metabolism to alleviate HUA, corresponding to the previous results. 36,53,58 Besides, the difference abundance score map of the pathway (Figure 8B) also confirmed that the downregulation of purine metabolism and ABC transporters contributed to the effect of HUA.…”

Section: Effects Of Tap On Serum Andsupporting

confidence: 53%

“…Interestingly, these metabolites decreased after TAP treatment, indicating that TAP may reduce serum UA by improving purine metabolism disorders. Similarly, CPE also decreased UA levels by improving purine metabolism disorders …”

Section: Resultsmentioning

confidence: 89%

“…Similarly, CPE also decreased UA levels by improving purine metabolism disorders. 53 3.9. Bioinformatics Analysis of Differential Metabolites.…”

Section: Effects Of Tap On Serum Andmentioning

confidence: 99%

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Identification of Hyperuricemia Alleviating Peptides from Yellow Tuna Thunnus albacares

Hao,

Ding,

Fan

et al. 2024

J. Agric. Food Chem.

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The development of food-derived antihyperuricemic substances is important for alleviating hyperuricemia (HUA) and associated inflammation. Here, novel peptides fromThunnus albacares (TAP) with strong antihyperuricemic activity were prepared. TAP was prepared by alkaline protease (molecular weight <1000 Da), with an IC 50 value of xanthine oxidase inhibitory activity of 2.498 mg/mL, and 5 mg/mL TAP could reduce uric acid (UA) by 33.62% in human kidney-2 (HK-2) cells (P < 0.01). Mice were fed a high-purine diet and injected with potassium oxonate to induce HUA. Oral administration of TAP (600 mg/kg/d) reduced serum UA significantly by 42.22% and increased urine UA by 79.02% (P < 0.01) via regulating urate transporters GLUT9, organic anion transporter 1, and ATP-binding cassette subfamily G2. Meantime, TAP exhibited hepatoprotective and nephroprotective effects, according to histological analysis. Besides, HUA mice treated with TAP showed anti-inflammatory activity by decreasing the levels of toll-like receptor 4, nuclear factors-κB p65, NLRP3, ASC, and Caspase-1 in the kidneys (P < 0.01). According to serum non-targeted metabolomics, 91 differential metabolites between the MC and TAP groups were identified, and purine metabolism was considered to be the main pathway for TAP alleviating HUA. In a word, TAP exhibited strong antihyperuricemic activity both in vitro and in vivo.

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