Cyclobutane based “overbred intermediates” and their exploration in organic synthesis

Abstract

“Overbred intermediates” are being used in organic synthesis for a long time, but these intermediates are not categorized as overbred intermediate, this name was given recently in Hoffman's book “Elements...

Organophotocatalytic [2+2] Cycloaddition of Electron‐Deficient Styrenes**

“…Cyclobutanes are strained four-membered rings that are frequently encountered in natural products, [1,2] as synthetic intermediates [3] and within pharmaceutical and agrochemical compounds. [4] They are highly valuable building blocks in the pharmaceutical industry, where interest in nonplanar compound cores has recently increased.…”

Skeletal diversification by C–C cleavage to access bicyclic frameworks from a common tricyclooctane intermediate

“…[8][9][10] While not immediately obvious, the use of compounds containing more C-C bonds than a desired target compound can be greatly simplifying in synthesis-especially if the additional bonds are easily introduced en route to the target structure. 11 Cyclopropanation and [2+2] cycloaddition reactions have been a particularly effective means to arrive at intermediates of this type as these reactions can form sterically congested C-C bonds that are also highly strained and reactive. [12][13][14][15] Strategies to accomplish manifold C-C cleavage reactions from a single substrate to access diverse targets remain underexplored.…”