Cycloartane Glycosides from Three Species of <i>Astragalus</i> (Fabaceae)

Linnek, Jens; Mitaine-Offer, Anne Claire; Miyamoto, Tomofumi; Tanaka, Chiaki; Paululat, Thomas; Avunduk, Sibel; Alankuş-Çalışkan, Özgen; Lacaille‐Dubois, Marie‐Aleth

doi:10.1002/hlca.201000157

Cited by 21 publications

(7 citation statements)

References 20 publications

(13 reference statements)

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“…The 31 carbon resonances of the aglycone part consisted of 6 methyl carbons; 11 methylene carbons, 1 of which was oxygenated; 8 methine carbons, 3 of which bore oxygen functionalities; and 7 quaternary carbons comprising 1 carbonyl and an oxygenated carbon. Both the 1 H upfield methylenic protons at δ H 0.36 and 0.56 (each 1H, doublet with J = 4.0 Hz) and the six unsaturation degrees of the aglycone moiety led to define a carboxylic-acid-substituted cycloartane scaffold [12,13] (Figure 1 and Supplementary Materials). The thorough analysis of the COSY, HSQC, and HMBC spectra led to fully assign the 1 H and 13 C signals for compound 1 (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Nervisides I–J: Unconventional Side-Chain-Bearing Cycloartane Glycosides from Nervilia concolor

et al. 2019

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Two new cycloartane glycosides, nervisides I–J, were isolated from Nervilia concolor whole plants. Their structures were unambiguously established by interpretation of their HRESIMS and 1D and 2D NMR data. These cycloartanes comprised a stereogenic center at C-24, the R configuration of which was assigned based on DFT-NMR calculations and the subsequent DP4 probability score. These compounds were tested for cytotoxicity against K562 and MCF-7 tumor cell lines, revealing mild cytotoxic activity.

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Section: Resultsmentioning

confidence: 99%

Nervisides I–J: Unconventional Side-Chain-Bearing Cycloartane Glycosides from Nervilia concolor

et al. 2019

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“…The plants of Astragalus genus have been proved to be the richest source of cycloartane-type saponins, possessing cardiotonic, hypocholesteremic, anti-depressive and antiblastic actions as well as immunomodulatory activity [7]. This promising spectrum of pharmacological effects led researchers to further search for structurally interesting cycloartane glycosides from the genus.…”

Section: Phytochemistrymentioning

confidence: 99%

“…Commonly, the aglycon of cycloartane-type saponins such as 1 – 62 possess an acyclic side chain at the 17-position. For the 17-acyclic side chain substituted cycloartane-type saponins, obtained from the Astragalus genus, the 24-position is often replaced by oxygen containing groups, and there are two kinds of steric configuration constituents with 24 S ( 1 – 28 ) [6,9,10,11,12,13,14,15,16,17,18,19,20,21,22] or 24 R ( 29 – 48 ) [7,14,15,16,17,23,24,25,26,27,28,29,30,31,32,33,34].…”

Section: Phytochemistrymentioning

confidence: 99%

“…Also, it is famed for its antimicrobial, antiperspirant, anti-inflammatory, diuretic and tonic effects [6]. Some plants in the Astragalus genus are well known for their pharmacological properties, particularly hepatoprotective, immunostimulant, and antiviral activities [7]. While, the most common use of this genus is as forage for livestock and wild animals, some plants in this genus have been recognized as being used in foods, medicines, cosmetics, as substitutes for tea or coffee, or as sources of vegetable gums.…”

Section: Introdutionmentioning

confidence: 99%

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A Review of Recent Research Progress on the Astragalus Genus

Li¹,

Qu²,

Dong³

et al. 2014

Molecules

240

148

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Astragalus L., is one of the largest genuses of flowering plants in the Leguminosae family. Roots of A. membranaceus Bge. var. mongholicus (Bge.) Hsiao, A. membranaceus (Fisch.) Bge. and its processed products are listed in the China Pharmacopeia for "qi deficiency" syndrome treatment. However, more and more researches on other species of Astragalus have been conducted recently. We summarize the recent researches of Astragalus species in phytochemistry and pharmacology. More than 200 constituents, including saponins and flavonoids, obtained from 46 species of Astragalus genus were collected for this article. In pharmacological studies, crude extracts of Astragalus, as well as isolated constituents showed anti-inflammatory, immunostimulant, antioxidative, anti-cancer, antidiabetic, cardioprotective, hepatoprotective, and antiviral activities. The goal of this article is to provide an overview of chemical and pharmacological studies on the Astragalus species over the last 10 years, which could be of value to new drug or food supplement research and development. OPEN ACCESS

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“…Others are a source of the economically important natural product, gum tragacanth. It is reported that some of Astragalus plants are well-known for their hepatoprotective, antiviral and immunostimulant activities [8]. Previous reports showed Astragalus plants to be a great source of saponins, flavonoids, and polysaccharides [9].…”

Section: Introductionmentioning

confidence: 99%

The Potential Hepatoprotective and Antioxidant Activities of Astragalus davisii against Paracetamol Induced Liver Damage in Rats

Foudah

Alqarni

Soliman

et al. 2020

JPRI

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The current study aimed to estimate in vitro antioxidant effect of Astragalus davisii (A. davisii) extract. Further, the possible protective effect of A. davisii against paracetamol (PCM)-induced liver injury was assessed in rats. A. davisii was tested for its antioxidant activity using DPPH radical scavenging assay. The hepatoprotective potential of the extract was assessed in rats following oral administration for 7 days. Liver injury was induced in rats following oral administration of PCM overdose. Hepatic biomarkers; alanine-aminotransferase, aspartate-aminotransferase, alkaline-phosphatase, γ-glutamyl transferase and bilirubin were increased, while total protein and albumin were reduced in PCM control animals. Additionally, the activities of superoxide dismutase (SOD), catalase and glutathione-peroxidase (GPx) and the levels of glutathione were significantly declined, while levels of hepatic malondialdehyde (MDA) were significantly elevated in PCM alone treated rats. Oral administration of A. davisii (400 mg/kg) prior to PCM inhibited the elevation in the levels of liver damage markers in serum and protected against oxidative stress. Histopathological remarks confirmed the hepatoprotective potential of the extract. The results suggest that A. davisii extract at 400 mg/kg protects liver against injury induced by PCM overdose.

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Cycloartane Glycosides from Three Species of Astragalus (Fabaceae)

Cited by 21 publications

References 20 publications

Nervisides I–J: Unconventional Side-Chain-Bearing Cycloartane Glycosides from Nervilia concolor

Nervisides I–J: Unconventional Side-Chain-Bearing Cycloartane Glycosides from Nervilia concolor

A Review of Recent Research Progress on the Astragalus Genus

The Potential Hepatoprotective and Antioxidant Activities of Astragalus davisii against Paracetamol Induced Liver Damage in Rats

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