Cyclo‐oxygenase‐2 over‐expression in sporadic colorectal carcinoma without lymph node involvement

Bruno, Benedetto; Heymann, Marie‐Françoise; Lièvre, Astrid; Nguyen, Jenny; Wilson, Kate; Bézieau, Stéphane; Mosnier, J.-F.; Galmiche, Jean–Paul

doi:10.1046/j.1365-2036.2003.01758.x

Cited by 9 publications

(8 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding raises the possibility that COX‐2 expression may be more intimately involved in the initial development, not in the progression of colorectal cancer. Our findings are consistent with the results of previous studies (17, 20, 21, 33–35).…”

Section: Discussionsupporting

confidence: 94%

“…By using immunohistochemistry, the prevalence of COX‐2 immunoreactivity in colorectal cancer reported in the literature varies widely, ranging from 25% to 100%, with the majority of studies reporting reactivity in approximately 70%–100% of cases examined (13, 17, 18, 20, 27–29, 32–35). In the current study, COX‐2 expression was present in all colorectal cancer cases irrespective of the clinicopathological characteristics of patients.…”

Section: Discussionmentioning

confidence: 99%

“…It is controversial whether COX‐2 expression in itself is a prognostic factor for survival of patients with colorectal cancer. Some authors have found a significantly increased cancer‐specific mortality associated with higher COX‐2 expression in tumor cells (17, 18), while others could not confirm the observations (19–21).…”

mentioning

confidence: 96%

See 2 more Smart Citations

Prognostic value of COX‐2 immunohistochemical expression evaluated by quantitative image analysis in colorectal cancer

Zafirellis

Agrogiannis

Zachaki

2008

APMIS

View full text Add to dashboard Cite

Epidemiological studies have shown that the inducible form of cyclooxygenase (COX-2) may be involved in colorectal carcinogenesis, but it is controversial whether its expression is a prognostic factor for colorectal cancer. The aim of the study was to examine the expression of COX-2 in colorectal cancer and investigate its prognostic relevance. Tissue sections of primary tumors from 132 patients undergoing curative resection for colorectal cancer were immunohistochemically examined for COX-2 expression. The levels of intensity and extent of COX-2 staining were quantified by use of a computerized image analysis system and correlated with various clinicopathological characteristics and survival. COX-2 immunoreactivity was observed in the cytoplasm of tumour epithelial cells of all colorectal cancer tissues examined. No significant correlation was found between levels of intensity and extent of COX-2 staining and various clinicopathological characteristics, including age, gender, tumor location, tumor size, tumor grade, depth of invasion, lymph node status and TNM stage. There was an inverse correlation between intensity and extent of COX-2 staining scores (Spearman's rho=-0.414; p<0.001). To analyze the prognostic value of intensity and extent of COX-2 staining, the patients were divided into four groups with respect to quartiles (< or =25; >25 to < or =50; >50 to < or =75; and >75). No significant disease-specific survival difference among the quartiles was found based on analysis of intensity (p=0.689) and extent (p=0.975) of COX-2 staining. These results suggest that the expression of COX-2 protein has no significant impact on the outcome of patients with colorectal cancer.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic value of COX‐2 immunohistochemical expression evaluated by quantitative image analysis in colorectal cancer

Zafirellis

Agrogiannis

Zachaki

2008

APMIS

View full text Add to dashboard Cite

show abstract

“…Actually, the negative prognostic value of Cox-2 overexpression has been reported in several studies on various carcinomas such as those of colon and rectum (12,14,17,27,28), stomach (29), esophagus (30), breast (31), lung (32,33), and ovaries (34).…”

Section: Discussionmentioning

confidence: 94%

Cyclooxygenase-2 Expression

Soumaoro

Uetake

Higuchi

et al. 2004

Clinical Cancer Research

230

172

View full text Add to dashboard Cite

Purpose: Recent studies have shown that cyclooxygenase (Cox)-2 may be involved in colorectal carcinogenesis. We aimed to determine whether Cox-2 expression in itself can predict outcome of colorectal cancer patient after surgery. In addition, the expression of Cox-1 was also evaluated.Experimental Design: Tissue samples of primary and secondary tumors from 288 patients undergoing surgical resections for colorectal adenocarcinoma were immunohistochemically examined for Cox-2 and Cox-1 expressions. The specimens were graded based on the intensity and extent of staining; then, the correlations between Cox-2 and Cox-1 expressions with clinicopathologic parameters and survival time were analyzed.Results: Expression of Cox-2 was positive in 70.8% of primary tumor, 92.0% of lymph node metastases, 100.0% of hepatic metastases, and was significantly associated with tumor size, depth of invasion, lymph node metastasis, vessels invasion, stage and recurrence. In contrast, Cox-1 was positive in 42.7% of primary tumor, 84.0% of lymph node metastases, 37.5% hepatic metastases, and was associated with only tumor size. Patients with Cox-2-positive tumors had a significant shorter survival time than those with negative tumors did (P ‫؍‬ 0.0006 by log-rank test); and, in a multivariate analysis, Cox-2 was an independent prognostic factor (P ‫؍‬ 0.0103; relative risk 4.114; 95% confidence interval, 1.397-12.120). Cox-1 status had no statistically effect on patient survival time.Conclusions: Elevated Cox-2 expression, but not that of Cox-1, was significantly associated with reduced survival and recognized as an independent prognostic factor in our cohort of colorectal cancer patients.

show abstract

“…26 Localization of COX-2 has been widely investigated in a variety of human neoplasms, including colorectal cancer. [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] However, to date there have been few reports regarding the relationship between COX-2, MT1-MMP, and MMP-2 expression in human colorectal cancer tissue and their relevance to clinicopathologic factors, including prognosis. 39 This study was designed to examine whether localization of COX-2 expression correlated with MT1-MMP and MMP-2 expression in a large series of colorectal cancer tissues, and to assess the prognostic significance of COX-2 protein in conjunction with other prognostic factors in colorectal cancer patients.…”

mentioning

confidence: 99%

Cyclooxygenase-2 Expression Correlates With Membrane-Type-1 Matrix Metalloproteinase Expression in Colorectal Cancer Tissue

Guo

Tatsuguchi

Shinji

et al. 2006

Diseases of the Colon &Amp; Rectum

View full text Add to dashboard Cite

This study indicates strong association between both cyclooxygenase-2 and membrane-type-1 matrix metalloproteinase expression, and membrane-type-1 matrix metalloproteinase and matrix metalloproteinase-2 in colorectal cancer. These results support our thesis of a direct correlation between cyclooxygenase-2 and membrane-type-1 matrix metalloproteinase expression--with consequent association between cyclooxygenase-2 and matrix metalloproteinase-2 activation, and tumor invasiveness andrecurrence in certain cases of colorectal cancer.

show abstract

Cyclo‐oxygenase‐2 over‐expression in sporadic colorectal carcinoma without lymph node involvement

Cited by 9 publications

References 35 publications

Prognostic value of COX‐2 immunohistochemical expression evaluated by quantitative image analysis in colorectal cancer

Prognostic value of COX‐2 immunohistochemical expression evaluated by quantitative image analysis in colorectal cancer

Cyclooxygenase-2 Expression

Cyclooxygenase-2 Expression Correlates With Membrane-Type-1 Matrix Metalloproteinase Expression in Colorectal Cancer Tissue

Contact Info

Product

Resources

About