Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-κB and Nrf2 signalling

Minelli, Alba; Grottelli, Silvia; Mierla, Annalisa; Pinnen, Francesco; Cacciatore, Ivana; Bellezza, Ilaria

doi:10.1016/j.biocel.2011.12.006

Cited by 61 publications

(45 citation statements)

References 38 publications

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“…Our data are consistent with existing evidence that sufficient VitD is known to be antiinflammatory and to suppress the NF-κB cellular stress response pathway [49, 57, 114–116]. Hydrogen peroxide (H 2 O 2 ) has been shown to modulate NF-κB activity thereby helping to regulate NF-κB-dependent processes including inflammation [40, 117–119].…”

Section: Discussionsupporting

confidence: 91%

Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: Implications for low vitamin D-dependent age-related cognitive decline

Keeney

Förster

Sultana

et al. 2013

Free Radical Biology and Medicine

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In addition to the well-known effects of vitamin D (VitD) in maintaining bone health, there is increasing appreciation that this vitamin may serve important roles in other organs and tissues, including the brain. Given that VitD deficiency is especially widespread among the elderly, it is important to understand how the range of serum VitD levels that mimic those found in humans (from low to high) affects the brain during aging from middle-age to old-age. To address this issue, twenty-seven male F344 rats were split into three groups and fed isocaloric diets containing low (100 IU/kg food), control (1000 IU/kg food), or high (10000 IU/kg food) VitD beginning at middle-age (12 months) and continued for a period of 4–5 months. We compared the effects of these dietary VitD manipulations on oxidative and nitrosative stress measures in posterior brain cortices. The low VitD group showed global elevation of 3-nitrotyrosine (3-NT) compared to control and high VitD treated groups. Further investigation showed that this elevation may involve dysregulation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway and NF-κB mediated transcription of inducible nitric oxide synthase (iNOS) as indicated by translocation of NF-κB to the nucleus and elevation of iNOS levels. Proteomic techniques were used to provide insights into potential mechanisms underlying these effects. Several brain proteins were found at significantly elevated levels in low VitD group compared to the control and high VitD groups. Three of these proteins, 6-phosphofructokinase, triosephosphate isomerase, and pyruvate kinase, are involved directly in glycolysis. Two others, peroxiredoxin-3 and DJ-1/PARK7, have peroxidase activity and are found in mitochondria. Peptidyl-prolyl cis-trans isomerase A (PPIA or cyclophilin A) has been shown to have multiple roles including protein folding, regulation of protein kinases and phosphatases, immunoregulation, cell signaling, and redox status. Together, these results suggest that dietary VitD deficiency contributes to significant nitrosative stress in brain and may promote cognitive decline in middle-aged and elderly adults.

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Section: Discussionsupporting

confidence: 91%

Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: Implications for low vitamin D-dependent age-related cognitive decline

Keeney

Förster

Sultana

et al. 2013

Free Radical Biology and Medicine

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“…Several lines of evidence indicate that many compounds, including various types of phytochemicals, exert protective effects through Nrf2 signalling activation and, on the other hand, by suppressing the NF‐ κ B pathway in different cell lines . Also, in human keratinocytes, Kumar et al.…”

Section: Discussionmentioning

confidence: 99%

Z‐ligustilide ameliorated ultraviolet B‐induced oxidative stress and inflammatory cytokine production in human keratinocytes through upregulation of Nrf2/HO‐1 and suppression of NF‐κB pathway

Uchi

Morino-Koga

et al. 2015

Experimental Dermatology

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Ultraviolet B (UVB), a harmful environmental factor, is responsible for a variety of skin disorders including skin inflammation through reactive oxygen species (ROS) and inflammatory mediator production. Here, we investigated the effect of Z-ligustilide (Z-lig), an active ingredient isolated from the medicinal plants Cnidium officinale and Angelica acutiloba, on UVB-induced ROS generation and inflammatory mediator production in normal human epidermal keratinocytes (NHEKs) as well as its underlying mechanisms. Z-lig significantly rescued UVB-induced NHEKs damage in a dosage-dependent manner. Pretreatment of NHEKs with Z-lig inhibited UVB-induced ROS production in NHEKs. Both silencing the nuclear factor E2-related factor 2 (Nrf2) and the supplement of tin protoporphyrin IX (SnPP), a haeme oxygenase-1 (HO-1) inhibitor, cancelled the inhibitory effect of Z-lig on UVB-induced ROS upregulation in NHEKs. Moreover, pretreatment of NHEKs with Z-lig reduced UVB-induced nuclear factor kappa B (NF-κB)-dependent inflammatory mediators (IL-6, IL-8 and MCP-1) production at both mRNA and protein level. In the presence of Z-lig, UVB-induced NF-κB subunit p65 nuclear translocation was abolished, and the IκBα degradation was suppressed. Taken together, these findings suggest that Z-lig can suppress UVB-induced ROS generation through Nrf2/HO-1 upregulation and inflammation by suppressing the NF-κB pathway, suggesting that Z-lig may be beneficial in protecting skin from UVB exposure.

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“…Other examples of antibiotics derived from aa-tRNAs are the cyclodipeptides (CDP), a large group of secondary metabolites with a notable range of clinical activities (Rodriguez and Carrasco, 1992; Prasad, 1995; Magyar et al, 1996; Waring and Beaver, 1996; Kanoh et al, 1999; Strom et al, 2002; Cain et al, 2003; Kanzaki et al, 2004; Jia et al, 2005; Kohn and Widger, 2005; Musetti et al, 2007; Minelli et al, 2012). It was originally proposed that formation of the CDPs was catalyzed by non-ribosomal peptide synthetases, which do not use aa-tRNAs as substrates.…”

Section: Aminoacyl-trnas As Non-ribosomal Substratesmentioning

confidence: 99%

tRNAs as regulators of biological processes

Raina¹,

Ibba²

2014

Front. Genet.

273

263

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Transfer RNAs (tRNA) are best known for their role as adaptors during translation of the genetic code. Beyond their canonical role during protein biosynthesis, tRNAs also perform additional functions in both prokaryotes and eukaryotes for example in regulating gene expression. Aminoacylated tRNAs have also been implicated as substrates for non-ribosomal peptide bond formation, post-translational protein labeling, modification of phospholipids in the cell membrane, and antibiotic biosyntheses. Most recently tRNA fragments, or tRFs, have also been recognized to play regulatory roles. Here, we examine in more detail some of the new functions emerging for tRNA in a variety of cellular processes outside of protein synthesis.

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Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-κB and Nrf2 signalling

Cited by 61 publications

References 38 publications

Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: Implications for low vitamin D-dependent age-related cognitive decline

Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: Implications for low vitamin D-dependent age-related cognitive decline

Z‐ligustilide ameliorated ultraviolet B‐induced oxidative stress and inflammatory cytokine production in human keratinocytes through upregulation of Nrf2/HO‐1 and suppression of NF‐κB pathway

tRNAs as regulators of biological processes

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