Cyclization of Stilbene and Its Derivatives

Gilbert, Andrew

doi:10.1002/chin.200418261

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…As shown in Fig. 1, the latter two had a phenanthrene ring between the adjacent phenyl groups, similar to the known photochemical reaction of stilbene‐like compounds 20. Thus P2 was also indicated to have the same phenanthrene ring in its structure.…”

Section: Resultssupporting

confidence: 62%

Liquid chromatography/mass spectrometric studies on atorvastatin and its stress degradation products

Shah

Kumar

Singh

2008

Rapid Comm Mass Spectrometry

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A comprehensive mass fragmentation pathway of atorvastatin, which has not been reported so far, was established by subjecting the drug to multi-stage mass spectrometric (MSn) studies. It was used along with liquid chromatography/mass spectrometric (LC/MS) and liquid chromatography/time-of-flight mass spectrometric (LC/TOFMS) analyses to identify the drug degradation products formed under stress conditions of hydrolysis, oxidation and photolysis. Other than lactone, which is a reported hydrolysis product, six unknown hydrolytic products could be identified, viz., dehydrated drug, dehydrated drug lactone, and diastereomers of the drug, drug lactone, dehydrated drug, and dehydrated drug lactone. Among the two products separated under oxidative conditions, one was lactone, again formed as a result of drug hydrolysis in an acidic environment of peroxide solution. The other was similar to a reported oxidative product. Under photolytic conditions in solution, one new product could be identified, while most of the others matched with those known from the literature. Hence overall a more complete degradation pathway of the drug was established than known at present, by using a stress testing approach and employing LC/MS techniques.

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Section: Resultssupporting

confidence: 62%

Liquid chromatography/mass spectrometric studies on atorvastatin and its stress degradation products

Shah

Kumar

Singh

2008

Rapid Comm Mass Spectrometry

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“…Photochemical cyclizations involving at least two unsaturated moieties play an important role in heterocyclic chemistry. 109,140,141,142 These reactions have also been applied to the synthesis of photoswitches and photochromic compounds with various heterocyclic moieties. 143 Such a reaction can be applied to the industrial production of (S)-indoline carboxylic acid 193 (Scheme 36).…”

Section: Photochemical Cyclizationsmentioning

confidence: 99%

Photochemical rearrangements in organic synthesis and the concept of the photon as a traceless reagent

Lefebvre

Hoffmann

2021

Nontraditional Activation Methods in Green and Sustainable Applications

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Many photochemical reactions are carried out under particular sustainable conditions. Often no chemical activation is necessary and the photon is considered as a traceless reagent. These reactions give access to unusual molecular structures and therefore are highly appreciated for application to organic synthesis, especially in heterocyclic chemistry. In this context, photochemical position isomerizations of heterocyclic compounds are discussed. Photochemical rearrangements induced by electron and hydrogen atom transfer (HAT) are also used for the preparation of heterocyclic compounds. Photochemical electrocyclization is discussed with sixmembered heterocycles such as pyridine derivatives. Finally, photochemically induced cyclization are presented as a very suitable method for the construction of heterocycles. The synthesis of biologically active compounds is particularly focused. Thus perspectives of sustainable chemistry are presented for the pharmaceutical and agrochemical industry.

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An Efficient Synthesis of Phenanthroindolizidine Core via Hetero Diels-Alder Reaction of In Situ Generated α-Allenylchalcogenoketenes With Cyclic Imines

Shimada

Suzuki

Yahaba

et al. 2019

Natural Product Communications

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Cyclization of Stilbene and Its Derivatives

Abstract: For Abstract see ChemInform Abstract in Full Text.

Cited by 3 publications

References 30 publications

Liquid chromatography/mass spectrometric studies on atorvastatin and its stress degradation products

Liquid chromatography/mass spectrometric studies on atorvastatin and its stress degradation products

Photochemical rearrangements in organic synthesis and the concept of the photon as a traceless reagent

An Efficient Synthesis of Phenanthroindolizidine Core via Hetero Diels-Alder Reaction of In Situ Generated α-Allenylchalcogenoketenes With Cyclic Imines

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