Cyclin I correlates with VEGFR-2 and cell proliferation in human epithelial ovarian cancer

Cybulski, Marek; Jarosz, Bożena; Nowakowski, Andrzej; Jeleniewicz, Witold; Seroczyński, Przemysław; Mazurek-Kociubowska, Magdalena

doi:10.1016/j.ygyno.2012.06.038

Cited by 24 publications

(24 citation statements)

References 30 publications

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“…Collective discoveries found that dysregulated expression of KDR could trigger proliferation and metastasis of tumors [48]. Meanwhile, association between KDR genetic variants and several diseases has been found in previous studies, such as ovarian cancer, endometriosis, coronary artery lesions of Kawasaki disease, and moyamoya [49]. However, the mechanism of KDR in tumorigenesis is still not well explained.…”

Section: Discussionmentioning

confidence: 99%

Genetic Variations of Kinase Inserts Domain Receptor (KDR) Gene Are Associated with the Risk of Astrocytomas

Gao

et al. 2015

Mol Neurobiol

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Astrocytomas is one of the most common central nervous system (CNS) tumors with high mortality rate. Kinase insert domain receptor (KDR) is involved in the regulation of tumor angiogenesis, migration, and vascular permeability. The aim of the study was to explore the relationship between KDR polymorphisms and risk of astrocytomas. Blood samples were collected from 157 astrocytomas patients and 160 healthy controls. Three tag-SNPs (rs2071559C/T, rs2305948T/C, and rs1870377A/T) were identified from the International HapMap Project Databases and genotyped using the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). We evaluated the astrocytomas risk caused by individual SNPs and haplotype using odds ratios (ORs) and their 95 % confidence intervals (CIs). In the overall individual SNP analysis, the C allele of rs2071559 was correlated with an increased risk of astrocytomas. However, individuals with mutant allele A and genotype TA + AA of rs1870377 showed a protective effect against astrocytomas. Subgroup analysis based on WHO tumor grade revealed that the C allele of rs2071559 had more influence with the risk of astrocytomas in the grade III-IV (OR = 1.91) subgroup than the grade I-II (OR = 1.47) group. Genotype TT of rs2305948 was found to be significantly associated with susceptibility of astrocytomas only in the grade III-IV subgroup. The protective effect of rs1870377 did not reveal significant difference between the grade III-IV and grade I-II subgroups. Meanwhile, stratified analysis demonstrated that mutation of rs2071559 and rs2305948 could elevate the risk of astrocytomas more significantly in the subgroup of smokers than the nonsmokers. Interestingly, the protective effect of rs1870377 was more obvious in the nonsmokers than the smokers. Additionally, haplotype-specific analysis showed that haplotype CCT and CTT were related with an increased risk of astrocytomas. We found that individual with variants of rs2071559*C and rs2305948*T might significantly elevate the risk of astrocytomas, while mutants of rs1870377*A was associated with the decreased risk of astrocytomas. Further studies about ethnically diverse populations with larger sample size should be performed to confirm the correlation between KDR gene polymorphisms and risk of astrocytomas.

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Section: Discussionmentioning

confidence: 99%

Genetic Variations of Kinase Inserts Domain Receptor (KDR) Gene Are Associated with the Risk of Astrocytomas

Gao

et al. 2015

Mol Neurobiol

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“…6 The other one is the possible involvement of Cyclin I in proliferation of cancer cells. 9,10 The increased level of Cyclin I protein was observed in breast, ovarian, and pancreatic cancer cells. 9,10,20 Although the contribution of Cyclin I to cancer formation associated with angiogenesis was suggested, 9,10 the precise mechanisms were unknown.…”

Section: Discussionmentioning

confidence: 99%

“…6 While most Cdks are activated in proliferating cells to promote cell cycle progression, the Cdk5 activity is predominantly detected in post-mitotic neurons, 7 and Cdk5 plays a role in a variety of neuronal functions, such as neuronal development, migration, and synaptic signaling. 8 Recent studies have suggested that Cyclin I expression is correlated with the proliferative activity and angiogenesis in human cancers, 9,10 and that increased levels of Cyclin I are associated with terminal growth arrest in cardiomyocytes. 11 However, it is unclear whether Cyclin I has a direct role in regulating cell proliferation, similar to other cyclins.…”

Section: Introductionmentioning

confidence: 99%

Cyclin I is involved in the regulation of cell cycle progression

et al. 2013

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Cyclins control cell cycle progression by regulating the activity of cyclin-dependent kinases (Cdks). Cyclin I is a member of the cyclin family because of the presence of a cyclin box motif. It has been suggested that Cyclin I is involved in various biological processes, such as cell survival, angiogenesis, and cell differentiation. However, whether or not Cyclin I has a role in regulating the cell cycle similarly to other cyclins has yet to be clarified. Therefore, we investigated the role for Cyclin I in cell cycle progression. We showed that the protein level of Cyclin I oscillated during the cell cycle, and that Cyclin I was subjected to ubiquitination and degradation in cells. The interaction between Cyclin I and Cdk5 was detected in cells overexpressed with both proteins. Furthermore, depletion of Cyclin I by siRNAs prevented cell proliferation, suggesting the positive role of Cyclin I for the cell cycle progression. In addition, flow cytometric analysis revealed that cells depleted of Cyclin I were accumulated at G₂/M phases. By using HeLa.S-Fucci (fluorescent ubiquitination-based cell cycle indicator) cells, we further confirmed that knockdown of Cyclin I induced cell cycle arrest at S/G₂/M phases. These results strongly suggest that Cyclin I has the role in the regulation of cell cycle progression.

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“…Cyclin-I, a member of the Cyclins family, was originally cloned from the human forebrain cortex (8). With a typical cyclin box, its correlation has been suggested with the proliferative activity and angiogenesis in human cancers (1). Identifying alterations in Matrilin-3 and Cyclin-I expressions during impairment and recovery of growth plate may be more significant in understanding the pathogenesis of TD.…”

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confidence: 99%

Expression of Genes Encoding Matrilin-3 and Cyclin-I During the Impairment and Recovery of Chicken Growth Plate in Tibial Dyschondroplasia

et al. 2014

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Tibial dyschondroplasia (TD) is a skeletal disease characterized by the disruption ofendochondral bone formation in avian species. The aim of this study was to determine the expression of Matrilin-3 and Cyclin-I genes in chicken growth plate during impairment and recovery from TD. Gene expressions were analyzed by polymerase chain reaction, and proteins by immunohistochemistry and in situ hybridizations. Expression of genes encoding Matrilin-3 and Cyclin-I were diminished with parallel decrease in proteins during TD, with fewer signs of cartilage cell differentiation. In contrast, there was an increase in mRNA expressions and protein levels of both genes during the recovery phase. These findings suggest that the Matrilin-3 and Cyclin-I genes also play a role in chondrocyte differentiation during the impairment and recovery of growth plate in TD.

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Cyclin I correlates with VEGFR-2 and cell proliferation in human epithelial ovarian cancer

Cited by 24 publications

References 30 publications

Genetic Variations of Kinase Inserts Domain Receptor (KDR) Gene Are Associated with the Risk of Astrocytomas

Genetic Variations of Kinase Inserts Domain Receptor (KDR) Gene Are Associated with the Risk of Astrocytomas

Cyclin I is involved in the regulation of cell cycle progression

Expression of Genes Encoding Matrilin-3 and Cyclin-I During the Impairment and Recovery of Chicken Growth Plate in Tibial Dyschondroplasia

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