“…The precise effects of phosphorylation on SAMHD1 activity are still under debate, however. Some evidence suggests phosphorylation negatively modulates SAMHD1 tetramerization and dNTPase activity (81, 99, 127), and this diminished dNTPase capacity is responsible for increased intracellular dNTP pools (93, 120, 121, 128). Other studies find limited or no effect of phosphorylation of SAMHD1 on catalytic activity(81, 108, 116, 117, 129), oligomerization equilibrium and allosteric activation(77, 129), or nucleic acid binding (83).…”