Cyclin D1 Pro241Pro (CCND1-G870A) Polymorphism Is Associated with Increased Cancer Risk in Human Populations: A Meta-Analysis

Abstract

The G870A polymorphism in the CCND1 gene may influence cancer risk. However, data from published studies with individual low statistical power have been controversial. To evaluate whether combined evidence shows an association between this polymorphism and cancer, we considered all available studies in a meta-analysis. Sixty studies were combined representing data for 18,411 cases and 22,209 controls. In our meta-analysis, we investigated overall sample and two ethnic populations (Caucasians and Asians) as well as nine cancer subtypes. Individuals who are homozygous for A allele (AA) were found to be associated with significantly increased cancer risk in overall sample [odds ratio (OR), 1.23; 95% confidence interval (95% CI), 1.13-1.33; P V 0.0001], Caucasians (OR, 1.16; 95% CI, 1.07-1.26; P = 0.0002), and Asians (OR, 1.26; 95% CI, 1.14-1.39; P V 0.001). Among the nine cancer subtypes investigated, modestly significant risk (ORs, 1.08 to 1.51; P = 0.02 to 0.04) was detected in breast, colorectal, head and neck, and other cancers. Highly significant and increased risk was found to be associated with genitourinary (OR, 1.51; 95% CI, 1.20-1.89; P = 0.0004) and blood-related cancers (OR, 1.62; 95% CI, 1.28-2.

The Association of a Variant in the Cell Cycle Control GeneCCND1and Obesity on the Development of Asthma in the Swiss SAPALDIA Study

“…The associations appear to be stronger among subjects homozygous for the CCND1 A allele in rs9344, the same genotype which in numerous studies including a large meta-analysis predisposed to various cancer subtypes across different ethnic populations (13). According to our study, these participants' lung tissue may be more prone to remodeling in response to obesity-related processes.…”

“…The expression of both genes is commonly altered in numerous cancer types. The single-nucleotide polymorphisms (SNPs) rs9344 [P242P] in CCND1 and rs1042522 [R72P] in TP53 are functionally very well characterized and have been associated with various cancer types, including in large meta-analyses (12)(13)(14). We previously demonstrated furthermore that these two polymorphisms modified the effect of particulate matter (PM 10 ) air pollution on lung function decline in the SAPALDIA cohort (15).…”

Genetic polymorphisms of CCND1 and PTEN in progression of esophageal squamous carcinoma

“…It has been well believed that genetic polymorphisms can result in subtle structural alteration, with an influence on protein expression or function. Many studies have reported that some relevant polymorphisms of CCND1 or PTEN are associated with an increased risk of some types of cancers (Sun et al, 2001;Jia et al, 2008;Pabalan et al, 2008;Rizvi et al, 2011). In the current study, the polymorphisms of CCND1 (807 G/A) and PTEN (rs701848 T/C and rs2735343 C/G) were selected to assess the relationship with the susceptibility of ESCC in Chinese population.…”

Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients

“…A recent meta-analysis of 60 published case-control studies has shown that, overall, individuals with the GA or AA genotype exhibited a 1.1-to 1.2-fold increased risk of developing cancer compared with individuals with the GG genotype. 6 With respect to colorectal cancer in particular, subjects with hereditary nonpolyposis colorectal cancer who carry the rs9344 polymorphism have been reported to acquire the disease at an earlier age. [7][8][9] Also, carriers of the A allele appear to be more frequent among individuals who developed non-syndromic colorectal cancer before the age of 60, 10 subjects with familial colorectal cancer 11,12 and affected women.…”