Cyclin D1 polymorphism, biochemoprevention and risk of upper aero-digestive tract cancer development

Cyclin D1 Gene G870A Variants and Primary Brain Tumors

“…However, findings are contradictory. Some of these studies indicated the association of CCDN1 G870A with cancer risk, prognosis, survival or characteristics of tumors such as larynx and oral cavity (Izzo, 2003), nonsmall lung cancer (Betticher et al, 1995), breast cancer (Yaylim-Eraltan et al, 2009), head and neck cancer (Zheng et al, 2001), ovarian cancer (Dhar et al, 1999), pituitary adenomas (Simpson et al, 2001). A meta-analysis which also includes our previous study (Yaylim-Eraltan et al, 2010), reported a significant association between colorectal cancer risk and G870A polymorphism.…”

Association of the Cylin D1 G870A Polymorphism with Laryngeal Cancer: Are they Really Related?

“…Regarding Lx SC cancers, results are in harmony with other cancer types. CCDN1 A allele was associated with increased CCDN1 expression and poor disease outcome in advanced T stages of the larynx and/or oral cavity in a study of 31 patients (Izzo et al, 2003;Shu et al, 2005).…”

“…This hypothesis has been tested in numerous studies however findings are contradictory. Some of the researches suggested the association of CCDN1 G870A with cancer development risk, prognosis and survival in non-small lung cancers Qiuling et al (2003), breast cancer (Grieu et al, 2003;Krippl et al, 2003;Shu et al, 2005;Yaylim et al, 2009), head and neck cancer Zheng et al (2001), ovarian cancer Dhar et al (1999), pituitary adenomas Simpson et al (2001) and larynx and oral cavity Izzo et al (2003). On the other hand, no significant association between G870A polymorphism and bladder cancer Sanyal et al (2004), pituitary adenomas Sanyal et al (2007) was reported.…”