Cyclin D1 overexpression correlates with poor prognosis in patients with tongue squamous cell carcinoma

Mineta, Hiroyuki; Miura, Kaoru; Takebayashi, Satoru; Ueda, Yoshio; Misawa, Kiyoshi; Harada, Hidekazu; Wennerberg, Johan; Dictor, Michael

doi:10.1016/s1368-8375(99)00078-0

Cited by 83 publications

(75 citation statements)

References 9 publications

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“…Second, suppression of cyclin D1 has been shown to inhibit the SCC growth in vitro and in vivo that leads to cellular apoptosis (26). Third, overexpression of cyclin D1 has been found associated with a more aggressive phenotype and reduced survival in patients with head and neck SCC including tongue cancer (27)(28)(29)(30)(31). The above evidence together with our results in this study suggest that cyclin D1 might play an important role during tumorigenesis of OSCC.…”

Section: Discussionsupporting

confidence: 76%

“…Conversely, cyclin D1 antisense oligonucleotides suppress SCC growth in vitro and in vivo, leading to cellular apoptosis (26). Moreover, overexpression of cyclin D1 has been found associated with a more aggressive phenotype and reduced survival in patients with head and neck SCC including tongue cancer (27)(28)(29)(30)(31). However, in OSCC, there were no significant differences in any of the clinical or pathological parameters and overall survival (32).…”

Section: Introductionmentioning

confidence: 99%

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Pin1 overexpression is associated with poor differentiation and survival in oral squamous cell carcinoma

Lu¹

2009

Oncol Rep

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Abstract. Phosphorylation on certain Ser/Thr-Pro motifs is a major oncogenic mechanism. The conformation and function of phosphorylated Ser/Thr-Pro motifs are further regulated by the prolyl isomerase Pin1. Pin1 has been shown to be prevalently overexpressed in human breast cancer cell lines and cancer tissues and to play a critical role in the transformation of mammary epithelial cells by activating multiple oncogenic pathways. Pin1 expression was found to be an excellent independent prognostic marker in prostate cancer. However, little is known about Pin1 and its downstream targets ß-catenin and cyclin D1 expressions in human oral cancers. In the present study, we quantified Pin1 expression in 74 paired normal/tumor human oral cancer samples as well as oral cancer cell lines. Pin1 was overexpressed in oral squamous cell carcinoma (OSCC) and its level correlated with ß-catenin accumulation and cyclin D1 expression. Moreover, we examined Pin1 mRNA expression in OSCC and cancer cell lines by RT-PCR analysis. The results showed that there is concordance in the relationship between the Pin1 mRNA level and Pin1 protein expression. The up-regulation of Pin1 mRNA expression in tumor part when comparing with that in non-tumor part was in agreement with that of the Pin1 protein overexpressed in OSCC. In addition, we showed that the molecular and immunohistochemical profiles of Pin1 overexpression were associated with progression of OSCC. Taken together, these results indicate that Pin1 is a regulator of cyclin D1 expression in OSCC and might play a role in oral oncogenesis. The overexpression of Pin1 can be used as an indicator for pathological diagnosis of OSCC.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Pin1 overexpression is associated with poor differentiation and survival in oral squamous cell carcinoma

Lu¹

2009

Oncol Rep

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“…5,6 Epidermal growth factor receptor (EGFR), a transmembranous protein that binds to ligands such as EGF and transforming growth factor-a, activates protein-tyrosine kinase, which mediates the signaling involved in cell proliferation and differentiation. 7 Apart from the well-established prognostic indicators of TNM staging and mode of invasion, these markers have high prognostic values in human cancer, [8][9][10][11][12][13][14][15][16][17][18][19][20][21] although there are some discrepancies. [22][23][24] In view of the prospective impact of multiple molecular marker accumulation on tumor progression, multiple-marker testing could provide us with more useful information for our definition of the biological behavior of oral cancer than single marker expression.…”

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confidence: 99%

Combined expression of p53, cyclin D1 and epidermal growth factor receptor improves estimation of prognosis in curatively resected oral cancer

et al. 2005

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p53, cyclin D1 and epidermal growth factor receptor (EGFR) are molecular markers that regulate the cell cycle or cell growth and play important roles in tumor development and progression. In this study, we examined the impact of immunohistochemical expression of these markers on tumor progression in 140 oral cancers. p53, cyclin D1 and EGFR were expressed in 64 cases (46%), 54 cases (39%) and 54 cases (39%), respectively, but there was no inter-relationship between any two of these markers. In the association of these markers with clinicopathological features, EGFR expression alone was significantly associated with poor differentiation (P ¼ 0.0008) and invasive growth pattern (P ¼ 0.0003). Any of these markers, including EGFR, had no significant impact on survival. Coexpression of all these markers, however, was significantly associated with invasive growth pattern (P ¼ 0.0149) and shortened survival (P ¼ 0.0181), and was a significant and independent unfavorable prognostic factor (P ¼ 0.0002), along with tumor size (P ¼ 0.0040), nodal metastasis (P ¼ 0.0137) and growth pattern (P ¼ 0.0017) in a multivariate analysis. Simultaneous coexpression of these markers in oral cancers might prove to be a useful indicator for identification of low-or high-risk patients.

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“…Cyclin D1 gene (CCDN1) is located on chromosome 11q13, encodes a critical cell cycle regulatory protein (Cyclin D1) that drives the cell cycle from G1 to S phase (4). Amplification and over expression of CCND1 has been reported in various carcinoma (5,6,7,8,9,10,11), so the study of cyclin D1 expression may improve our knowledge about the biological substrate of OKC and amelobelastomabehavior.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical comparison of cyclin D1 expression in amelobelastoma, odontogenic keratocyst and radicular cyst

2016

Int. J. Curr. Res. Chem. Pharm. Sci

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Objective:The present study was undertaken to compare expression ofcyclin D1 in the epithelial part of odontogenickeratocysts, radicular cysts and ameloblastomas. Material and Method:In this observational and cross-sectional study, immunohistochemical staining of cyclin D1 on formalinfixed, paraffin-embedded tissue sections of odontogenickeratocysts (n=14), radicular cysts (n=14) and amelobelastoma (n=14) was performed by standard EnVision method. Then, slides were studied to evaluate the following parameters in epithelial part of lesions: expression, expression pattern, staining intensity and localization of expression and clinicopathological parameters : gender, mean age and site of the lesion. Results:The data analysis showed statistically significant difference in cyclin D1 expression in studied groups (p<0.05). Assessment of staining localization and staining pattern showed basal andparabasal localization and more cases of diffuse pat tern in odontogenickeratocysts, but difference was not statistically significant among groups respectively (p=0.393, 0.465). Considering staining intensity, cyclin D1 positive cells in odontogenickeratocysts showedmost cases of strong intensity, different from r adicular cysts and Amelobelastoma. The difference was statistically significant (p=0.002).Conclusion: these findings could support the theory about neoplastic origin of odontogenickeratocysts, but results may support that, these lesions are developmental cysts with neoplastic properties because of the high intrinsic growth potential.

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Cyclin D1 overexpression correlates with poor prognosis in patients with tongue squamous cell carcinoma

Cited by 83 publications

References 9 publications

Pin1 overexpression is associated with poor differentiation and survival in oral squamous cell carcinoma

Pin1 overexpression is associated with poor differentiation and survival in oral squamous cell carcinoma

Combined expression of p53, cyclin D1 and epidermal growth factor receptor improves estimation of prognosis in curatively resected oral cancer

Immunohistochemical comparison of cyclin D1 expression in amelobelastoma, odontogenic keratocyst and radicular cyst

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