Cyclin D1 Immunoreactivity in Meningiomas

Milenković, Sanja; Marinkovic, Tatjana; Jovanović, Milan B.; Djuričić, Slaviša; Berisavac, Ivana; Berisavac, Iva

doi:10.1007/s10571-008-9278-x

Cited by 15 publications

(20 citation statements)

References 36 publications

(33 reference statements)

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“…38 The investigators pointed out that cyclin D1 expression was correlated with grade 38 and with other markers such as proliferating cell nuclear antigen, Ki-67, 2,38 and p53. 2 However, the correlation with clinical outcome has not been evaluated.…”

Section: Cyclin D1mentioning

confidence: 99%

Expression of Minichromosome Maintenance MCM6 Protein in Meningiomas is Strongly Correlated With Histologic Grade and Clinical Outcome

Gauchotte

Vigouroux²,

Rech³

et al. 2012

American Journal of Surgical Pathology

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The 2007 World Health Organization histologic grading of meningiomas is associated with recurrence and clinical outcome. However, distinction of grade I from grade II (atypical) meningiomas can be challenging. In the World Health Organization classification, there are 4 parameters on the basis of which grade II status can be determined: mitotic rate, cytoarchitectural features, brain invasion, and/or histologic subtype. Furthermore, this classification fails to detect grade I recurrent meningiomas, for which other prognostic criteria would be needed. The aim of this study was to evaluate the respective value of several markers involved in cell cycle as effective tools to predict recurrence. This retrospective study was based on a series of 59 meningiomas (grade I: 32 of 59, grade II: 27 of 59, all harboring ≥4 mitoses/1.6 mm), analyzed with the following immunohistochemical markers: MCM6, Ki-67, PHH3, cyclin D1, and p53. We found a significant correlation between histologic grade and mean labeling index for MCM6 (grade I: 21.8% vs. grade II: 65.8%; P<0.001), Ki-67 (3.2% vs. 16.9%; P<0.001), PHH3 (0.7‰ vs. 2.8‰; P<0.001), cyclin D1 (50.4% vs. 70.0%; P=0.005), and p53 (17.3% vs. 32.4%; P=0.017). Histologic grading and mitotic index were correlated with progression-free survival (P=0.010 and P=0.020, respectively). A nearly linear correlation was found between progression-free survival and staining for MCM6 (P<0.001), Ki-67 (P=0.003), and PHH3 (P=0.037) but not for cyclin D1 (P=0.400) and p53 (P=0.758). The interobserver agreement coefficients for MCM6, Ki-67, PHH3, cyclin D1, and p53 were, respectively, 0.97 (95% confidence interval, 0.95-0.98), 0.93 (0.89-0.96), 0.81 (0.70-0.88), 0.90 (0.83-0.94), and 0.84 (0.73-0.90). In conclusion, because of its strong level of expression and sharp difference in labeling index between indolent and recurrent tumors, MCM6 is the most efficient marker to identify tumors with a high risk of recurrence.

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Section: Cyclin D1mentioning

confidence: 99%

Expression of Minichromosome Maintenance MCM6 Protein in Meningiomas is Strongly Correlated With Histologic Grade and Clinical Outcome

Gauchotte

Vigouroux²,

Rech³

et al. 2012

American Journal of Surgical Pathology

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“…demonstrated markedly higher expression in atypical and anaplastic meningiomas . Milenković et al . and Ahmad et al .…”

Section: Discussionmentioning

confidence: 86%

Anaplastic and meningothelial meningiomas in a single tumor: A “dedifferentiated meningioma”?

et al. 2016

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The patient was a 74-year-old man, who developed progressive cognitive impairment and gait instability. Neuroradiological examination demonstrated a large and predominantly extra-axial tumor spreading over the bilateral frontal base, indicative of olfactory groove meningioma. The greater part of the resected tumor consisted of a dense, patternless proliferation of large, round or polygonal cells, and compactly fascicular growth of spindle cells. Tumor cells showed markedly anaplastic cytological features. In small areas of the tumor, a typical meningothelial meningioma showing no cellular atypism was found. Both tumor components were closely juxtaposed and no pathological features of an intermediate grade (atypical meningioma) were noted. Shortly after the operation, the patient developed a local recurrence of the tumor and multiple metastases to the cerebrum, bone and skin. Anaplastic meningioma is a rare, highly malignant neoplasm which arises de novo or as a result of the progressive transformation of a low-grade meningioma. The coexistence of anaplastic and low-grade components in a single meningeal tumor has been rarely reported. This dimorphic appearance is reminiscent of "dedifferentiation", a phenomenon infrequently seen in various mesenchymal and salivary gland neoplasms. We think that the term "dedifferentiated meningioma" can be appropriately applied to tumors such as that reported herein.

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“…The percentage of cells expressing Ki-67 and cyclin D1 were obtained from cells with the highest staining intensity in 10 high-power fields (HPF). The percentage of labeled cells = number of labeled cells/total counted cells ×100 5 . The intensity and extent of positive Vav3 cytoplasmic labeling were semi-quantitatively assessed and scored as 0 (no staining), +1 (weak and focal staining in <25% of tissue), +2 (moderate intensity in 25-50% of tissue), +3 (moderate intensity in >50% of tissue), and +4 (strong and diffuse staining in >50% of tissue 6 .…”

Section: Evaluation Of Immunostainingmentioning

confidence: 99%

SPARC and Vav3 Expression in Meningioma: Factors Related to Prognosis

Jiang

Song

Liu

et al. 2013

Can. J. Neurol. Sci.

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Background:Meningiomas account for approximately 24-30% of primary intracranial neoplasms. Histopathologic grade and degree of resection are two major prognostic factors. The aim of this study was to determine the factors associated with the prognosis of meningioma.Methods:We used immunohistochemistry to analyze the expression levels of Vav3, SPARC, p-Akt, cyclin D1, and Ki-67 in 287 meningiomas of all grades.Results:The expression of Vav3, SPARC, p-Akt, cyclin D1, and Ki- 67 significantly increased with meningioma grade (p<0.01), and was higher in brain-invasive meningiomas compared to non-invasive meningiomas (WHO grade I) (p<0.05). Furthermore, the expression of Vav3, p-Akt, and Ki-67 was higher in recurrent meningiomas compared to non-recurrent meningiomas (WHO grade I) (p<0.05).Conclusion:The expression of Vav3, SPARC, p-Akt, cyclin D1, and Ki-67 in meningiomas appears to correlate with meningioma invasiveness, aggressiveness, and recurrence.

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Cyclin D1 Immunoreactivity in Meningiomas

Abstract: Our comparative study of proliferative markers in meningiomas demonstrated Cyclin D1 as a very useful proliferative marker in meningiomas.

Cited by 15 publications

References 36 publications

Expression of Minichromosome Maintenance MCM6 Protein in Meningiomas is Strongly Correlated With Histologic Grade and Clinical Outcome

Expression of Minichromosome Maintenance MCM6 Protein in Meningiomas is Strongly Correlated With Histologic Grade and Clinical Outcome

Anaplastic and meningothelial meningiomas in a single tumor: A “dedifferentiated meningioma”?

SPARC and Vav3 Expression in Meningioma: Factors Related to Prognosis

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