Cyclin D1 expression and its possible regulation in chewing tobacco mediated oral squamous cell carcinoma progression

Mishra, Rajakishore; Das, Bibhu Ranjan

doi:10.1016/j.archoralbio.2009.07.003

Cited by 41 publications

(39 citation statements)

References 42 publications

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“…Cyclin D1 expressions was not observed in six of the control cases. This is consistent with previous studies of total absence of cyclin D1 expressions in normal oral mucosal biopsies [1,12,37]. The absence of cyclin D1 expression in normal individuals could be attributed to the short half life of wild type cyclin D1 protein, hence unable to detect by immunohistochemical methods.…”

Section: Resultssupporting

confidence: 81%

“…With regard to cyclin D1 expression and grading in oral squamous cell carcinoma cyclin D1 expression increased with decrease in differentiation [1,11]. Since four cases, in this study belonged to moderately differentiated squamous cell carcinoma, 15 belonged to well differentiated squamous cell carcinoma and only one belonged to poorly differentiated squamous cell carcinoma, association between cyclin D1 expression and histological grades is not found statistically.…”

Section: Resultsmentioning

confidence: 53%

“…and its overexpression has been correlated to advanced clinical stage, [33] poor prognosis, [32], 8(8,32) increased risk of recurrence [15] and lymph node metastasis. [6,7,34] A few studies have been carried out to correlate cyclin D1 expression with tobacco use, [9] areca quid chewing and poor prognosis, [10] different degrees of dysplasias and SCC, [12] cisplatin resistance, [13] cyclin dependant kinases [16] in oral squamous cell carcinomas and some have been carried out to correlate the expression of cyclin D1 with histological grading of this neoplasm [1,11,14,17]. However some authors found no clinical correlation [35,36].…”

Section: Resultsmentioning

confidence: 99%

“…[6][7][8][9][10][11][12][13][14][15][16] and some are carried out to correlate the expression of cyclin D1 with histological grading of these neoplasms [1,11,14,17]. However the results have not been consistent and conclusive.…”

Section: Dentistry Sectionmentioning

confidence: 99%

“…Squamous cell carcinoma is the most common malignant epithelial neoplasm affecting the oral cavity. In Indian subcontinent oral cancer is mainly due to chewing tobacco and tobacco related products [1].…”

Section: Introductionmentioning

confidence: 99%

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Cyclin D1 Gene Expression in Oral Mucosa of Tobacco Chewers”–An Immunohistochemical Study

Basnaker

Bnvs

2014

JCDR

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Objective: The objective of the present study was to evaluate the expression of cyclin D1 in normal oral mucosa of both non tobacco habituated and tobacco habituated individuals histologically and also compare and correlate cyclin D1 expression with histopathologically confirmed cases of oral squamous cell carcinomas. Study Design:The present study involved 20 cases of tobacco habituated individuals with normal oral mucosal tissue and 20 histopathologically confirmed cases of squamous cells carcinomas. Twelve cases of non tobacco habituated individuals served as control group. Chi-square analysis was used to determine statistical significance.Results: Fifty percent of control cases, 70% of squamous cell carcinoma cases and 80% of tobacco habituated individuals of clinically normal mucosa showed cyclin D1 positivity. Thirteen cases with tobacco chewing habit, with clinically normal mucosa, showed dysplasia, out of which seven were mildly dysplastic and six were moderately dysplastic. A larger percentage of cyclin D1 expression was observed in lower grade dysplasias (53.8%) than higher grade dysplasias (46.1%). However statistical analysis showed no significant association between groups. Chi-square value was < 7.82 for p=0.05. Conclusion:The finding of cyclin D1 expression in 80% of tobacco users with clinically normal mucosa indicates that the mutation of cyclin D1 occurs early, even before clinical changes are apparent. This finding appears to be previously unreported. The presence of dysplasia in the same group and cyclin D1 expression in 84.6% of dysplastic cases show that the patients are susceptible for further changes, including progression to higher grades of dysplasia and development of carcinoma. Relatively lower expression of cyclin D1 positivity (70%), in oral cancer patients, when compared with tobacco users with clinically normal mucosa (80%) is indicative of increased traverse of the cell through the cell cycle, which may occur early in tumor progression. Cyclin D1 immunoreactivity was detected in all the three study groups.

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Section: Resultssupporting

confidence: 81%

Section: Resultsmentioning

confidence: 53%

Section: Resultsmentioning

confidence: 99%

Section: Dentistry Sectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cyclin D1 Gene Expression in Oral Mucosa of Tobacco Chewers”–An Immunohistochemical Study

Basnaker

Bnvs

2014

JCDR

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CCND1 amplification and protein overexpression in oral squamous cell carcinoma of young patients

et al. 2011

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Pluripotency transcription factor Nanog and its association with overall oral squamous cell carcinoma progression, cisplatin‐resistance, invasion and stemness acquisition

et al. 2020

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Background: Cisplatin-resistant oral squamous cell carcinoma (OSCC) cells acquire stem-like characteristics and are difficult to treat. Nanog is a transcription factor and needed for maintenance of pluripotency, but its transcription-promoting role in OSCC progression and cisplatin resistance is poorly understood. Methods: Here, 110 fresh human tissue specimens of various stages, including invasive (N 1-3)/chemoradiation-resistant OSCC samples, cisplatin-resistant (CisR-SCC-4/-9) OSCC cells/parental cells, photochemical ECGC, and siRNA (Nanog) were used. Results: Nanog overexpression was associated with overall progression, chemoresistance, and invasion of OSCC. Nanog recruitment to c-Myc, Slug, Ecadherin, and Oct-4 gene promoter was observed. Positive correlation of Nanog protein expression with c-Myc, Slug, cyclin D1, MMP-2/-9, and Oct-4 and negative correlation with E-cadherin gene expression were found. Knockdown of Nanog and treatment of epicatechin-3-gallate reversed cisplatin resistance and diminished invasion/migration potential. Conclusion: Nanog directly participated in the regulation of Slug, E-cadherin, Oct-4, and c-Myc genes, causing cisplatin resistance/recurrence of OSCC.

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Cyclin D1 expression and its possible regulation in chewing tobacco mediated oral squamous cell carcinoma progression

Cited by 41 publications

References 42 publications

Cyclin D1 Gene Expression in Oral Mucosa of Tobacco Chewers”–An Immunohistochemical Study

Cyclin D1 Gene Expression in Oral Mucosa of Tobacco Chewers”–An Immunohistochemical Study

CCND1 amplification and protein overexpression in oral squamous cell carcinoma of young patients

Pluripotency transcription factor Nanog and its association with overall oral squamous cell carcinoma progression, cisplatin‐resistance, invasion and stemness acquisition

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