Cyclical parenteral nutrition

Matuchansky, C; Messing, Bernard; Beliah, M.; Jeejeebhoy, K. N.; Beau, Philippe; Allard, Johane P.

doi:10.1016/0140-6736(92)92116-w

Cited by 42 publications

(12 citation statements)

References 31 publications

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“…Cyclical parenteral nutrition has been shown to maintain hormonal rhythms more than a continuous infusion, and this was associated with clinically beneficial effects [16]. However, the drugs used to provide sedation for ventilated patients are known to suppress circadian rhythmicity.…”

Section: Discussionmentioning

confidence: 99%

Use of 2 % propofol to produce diurnal sedation in critically ill patients

McLeod

Wallis

Dick

et al. 1997

Intensive Care Medicine

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Section: Discussionmentioning

confidence: 99%

Use of 2 % propofol to produce diurnal sedation in critically ill patients

McLeod

Wallis

Dick

et al. 1997

Intensive Care Medicine

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“…Cyclical PN should be considered for patients who are hemodynamically and metabolically stable, have increasing activity and mobility, need long-term support (months to years), or need mobilization of lipid stores. In a review article by Matuchansky et al [39], the benefits of cyclic PN are cited as producing higher rates of lipid oxidation, lower rates of lipid storage, gains in visceral protein, and less fluid imbalance as compared with continuous PN. These benefits are especially important for patients who already have excess fat stores and for those on hypocaloric support who need to maintain LBM and liberate lipids from stores for essential fatty acids.…”

Section: Parenteral Formula Selection Considerationsmentioning

confidence: 97%

Nutritional support of the obese patient

Roth¹,

Kushner

Bateman³

2005

Curr Gastroenterol Rep

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Overweight and obesity is the most common chronic disease in the United States and is associated with an increased risk for morbidity and mortality. For the hospitalized patient, the mechanical, metabolic, and inflammatory physiologic changes induced by obesity necessitate additional considerations for care. Calculation of nutritional requirements is problematic and challenging due to difficulty in measuring body composition and energy expenditure. Provision of selective hypocaloric feeding in this population may be particularly beneficial in reducing complications of hyperglycemia, fluid overload, and reduction in fat mass. Clinical care should incorporate a team approach that addresses the special nutritional and metabolic needs of this population.

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“…61 Compared with continuous infusion of TPN, cyclic infusion has been shown to reduce the incidence of liver-related complications. 62 In addition, overfeeding, and ω-6 fatty acids in excess of 1 g/kg per day in the absence of overfeeding, have been shown to increase the incidence of liver disease. 21,63 TPN-induced steato hepatitis is similar to nonalcoholic steato hepatitis.…”

Section: Liver-related Complicationsmentioning

confidence: 99%

Treatment of intestinal failure: home parenteral nutrition

Mullady

O'Keefe

2006

Nat Rev Gastroenterol Hepatol

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Intestinal failure can result from surgical resection, obstruction, dysmotility, congenital deficiencies or disease-associated loss of absorption. Before the development of intravenous feeding in the late 1960s, the condition was fatal, but by the 1990s approximately 40,000 patients were being successfully managed on long-term home parenteral nutrition (HPN) annually in the US. Survival on HPN depends on the nature of the underlying medical condition: over 80% of Crohn's disease patients survive for 5 years, but only 20% of cancer patients survive for 1 year. Although a patient's nutritional status is easy to maintain, there are serious long-term complications that arise from bypassing the gut and infusing nutrients directly into the systemic circulation. Catheter sepsis occurs about once per year (range 0-12 times). Abnormalities in liver function tests are common, but end-stage liver disease is rare. Central venous thrombosis develops in nearly all patients after 5 years. Although approximately 80% of patients on HPN are completely rehabilitated at home, their quality of life is impaired by the perpetual dependence on nocturnal intravenous infusions (every 8-12 h). In conclusion, HPN has allowed patients with previously fatal intestinal failure to survive and lead relatively normal lives at home, but their quality of life remains impaired by the dependence on intravenous infusions and complications that progress with time.

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Cyclical parenteral nutrition

Cited by 42 publications

References 31 publications

Use of 2 % propofol to produce diurnal sedation in critically ill patients

Use of 2 % propofol to produce diurnal sedation in critically ill patients

Nutritional support of the obese patient

Treatment of intestinal failure: home parenteral nutrition

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