Cyclic Vomiting Syndrome in Children

Raucci, Umberto; Borrelli, Osvaldo; Nardo, Giovanni Di; Tambucci, Renato; Pavone, Piero; Salvatore, Silvia; Baldassarre, Maria Elisabetta; Cordelli, Duccio Maria; Falsaperla, Raffaele; Felici, Enrico; Ferilli, Michela Ada Noris; Grosso, Salvatore; Mallardo, Saverio; Martinelli, Diego; Quitadamo, Paolo; Pensabene, Licia; Romano, Claudio; Savasta, Salvatore; Spalice, Alberto; Strisciuglio, Caterina; Suppiej, Agnese; Valeriani, Massimiliano; Zenzeri, Letizia; Verrotti, Alberto; Staiano, Annamaria; Villa, Maria Pia; Ruggieri, Martino; Striano, Pasquale; Parisi, Pasquale

doi:10.3389/fneur.2020.583425

Cited by 27 publications

(35 citation statements)

References 206 publications

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“…Pharmacological prophylaxis is suggested based upon the frequency and severity of CVS episodes and is applied in the intercritical periods. 1,2,13,22 As the first choice in prophylactic therapy, the NASPGHAN task force recommends cyproheptadine in children below 5 years of age and amitriptyline in patients over 5 years of age. 13 Anticonvulsants, including valproate, levetiracetam, and topiramate, are also increasingly being used in the prophylaxis of pediatric CVS.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15] Whatever classification is used, the diagnosis of CVS is clinical and requires appropriate medical evaluation to perform a positive diagnosis. 1,2,14 Despite a good prognosis, CVS may be a severe and debilitating condition, and significantly affect the long-term quality of life of children and their families. Moreover, the annual average economic burden per patient (and family), including emergency department visits, hospital admission, diagnostic investigations, and missed work, is significantly high.…”

Section: Conclusion and Inferencesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Cyclic vomiting syndrome (CVS) is defined as recurrent episodic attacks of intense nausea and vomiting, usually stereotypical in the individual and with predictable timing of acute episodes, and complete resolution of symptoms between attacks. 1,2 The estimated prevalence is 1.9%-2.3%, while the incidence is 1.7-2.7/100,000 children/year, with a peak among school-aged children. [3][4][5] CVS typically begins in childhood, with a mean age of onset of 3.5-7 years and a slightly higher prevalence in females vs. males (86 vs. 57%; female/male ratio 1.3:1).…”

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confidence: 99%

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Clinical features and long‐term outcomes in pediatric cyclic vomiting syndrome: A 9‐year experience at three tertiary academic centers

Dipasquale

Falsaperla

Bongiovanni

et al. 2021

Neurogastroenterology Motil

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Background: Pediatric cyclic vomiting syndrome (CVS) is a little-known clinical condition, frequently diagnosed with delay. This study aims to describe the clinical presentation and management and to define possible predictive factors of the disease outcome. Methods:In this retrospective study, all children who were diagnosed with CVS during the period 2010-2019 in three tertiary academic centers were included. The association between clinical variables and outcomes was investigated.Key Results: Fifty-seven children were included (male/female ratio 1.3:1; mean age at diagnosis 8.2 years). At the time of diagnosis, 63% of children had at least one episode every month. One or more prodromes were reported by 75% of patients. Family history of migraine was reported for 47% of children. Nearly, all of the children were started on prophylactic treatment. The median follow-up period was 29 months ± 15.Overall, 56% of children had resolution of vomiting. Twenty-six percent of children developed migraine. There were no differences in gender, age at onset, duration of follow-up, severity, medication, family history, or trigger factors between children

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Section: Discussionmentioning

confidence: 99%

Section: Conclusion and Inferencesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Clinical features and long‐term outcomes in pediatric cyclic vomiting syndrome: A 9‐year experience at three tertiary academic centers

Dipasquale

Falsaperla

Bongiovanni

et al. 2021

Neurogastroenterology Motil

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“…Son yıllarda, yetişkinlerde de SKS tanısı alan hastaların çocuklardan daha yaygın olabileceği, ancak çoğu zaman klinisyenler tarafından tanı alamadığı ya da tanı almakta geç kalındığı ortaya çıkmıştır [4]. Yapılan son çalışmalarda hastalığın etiyopatogenezinde anormal beyin-bağırsak yollarının, mitokondriyal enzimopatilerin, gastrointestinal motilite bozukluklarının, kalsiyum kanalı anormalliklerinin ve tetikleyici bir çevresel uyarana yanıt olarak hipotalamik-hipofiz-adrenal ekseninin hiperaktivitesinin etkili olduğunu göstermektedir [5]. Türkiye'de yapılan bir çalışmada okul çağındaki çocuklarda SKS sıklığının %1,9 olduğu rapor edilmiştir [6].…”

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The Effect of m.3010G> A Variant on Cyclic Vomiting Syndrome in Turkish Population

Ergin

Inci

Okur

et al. 2021

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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Siklik kusma sendromu (SKS) sık görülen gastrointestinal fonksiyonel bir düzensizliktir. Gastrointestinal fonksiyonel düzensizliklerin mitokondriyal polimorfizmlerle ilişkili olduğu gösterilmiştir. Bu çalışmada, m.3010G>A değişikliğini taşıyan hastalarda klinik bulguların incelenmesi amaçlanmıştır. Gereç ve Yöntemler: Kliniğimize mitokondriyal hastalık şüphesi ile gelen 55 hastadan, periferik kandan mitokondriyal DNA izolasyonu yapılmıştır. Yeni nesil DNA dizileme ile tüm mitokondriyal genom DNA dizi analizi yapılarak m.3010G>A değişikliği olan hastalar saptanmıştır. Bu hastalarda klinik bulgular incelenmiştir. Bulgular: Toplam 55 hastada yapılan mitokondriyal genom analizinde altı farklı hastada m.3010G>A değişikliği saptanmıştır. m.3010G>A değişikliği saptanan bu hasta grubunda SKS ile ilgili klinik bulgular saptanmamıştır. Sonuç: Daha önce yapılan çalışmalarda m.3010G>A değişikliğinin SKS ile ilişkili olabileceği gösterilmiş olsa da bizim çalışmamızda katılan hastalarda bu bulgular bulunmamaktadır. Yine de SKS'nin ileri yaşlarda da ortaya çıkabileceği göz önünde bulundurulmalı ve yakın takip edilmelidir.

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Good response to rectal diazepam in refractory cases of cyclic vomiting: A case‐series and review of the literature

Togha,

Babaei,

Jameie

2023

Clinical Case Reports

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Key Clinical MessageAlthough increasing in number, cases of CVS are being frequently misdiagnosed and many are refractory to the available treatments. This paper draws attention to a timely consideration of this disorder upon suspicion and proposes rectal diazepam and cinnarizine as highly effective treatments in refractory cases of CVS.AbstractCyclic vomiting syndrome (CVS) is a set of recurrent episodic attacks of nausea and vomiting. This is a migraine‐related disorder that mostly affects children. Several medications have been recommended for abortive and prophylactic treatment. Unfortunately, in some cases, the treatment is not completely effective and affects the quality of life of the sufferer. In this paper, we report on two cases of children experiencing refractory CVS attacks who were not responsive to recommended medications for acute phase and prophylaxis. This account highlights the efficacy of rectal diazepam for the acute phase of CVS and cinnarizine, an anti‐migraine and anti‐histamine agent, for prophylaxis of further attacks.

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Cyclic Vomiting Syndrome in Children

Cited by 27 publications

References 206 publications

Clinical features and long‐term outcomes in pediatric cyclic vomiting syndrome: A 9‐year experience at three tertiary academic centers

Clinical features and long‐term outcomes in pediatric cyclic vomiting syndrome: A 9‐year experience at three tertiary academic centers

The Effect of m.3010G> A Variant on Cyclic Vomiting Syndrome in Turkish Population

Good response to rectal diazepam in refractory cases of cyclic vomiting: A case‐series and review of the literature

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