Cyclic therapy of osteoporosis with neutral phosphate and brief, high-dose pulses of etidronate

Le, Mallette; Leblanc, Adrian; Jl, Pool; Ji, Mechanick

doi:10.1016/0378-5122(89)90053-4

Cited by 2 publications

(2 citation statements)

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“…Sixteen were [18][19][20][21][22][23][24][25], lack of randomization (7 trials) [26][27][28][29][30][31][32] and duration of less than 1 year (1 trial) [33]. Table 2 presents the characteristics of the 13 studies, including a total of 1267 women, that met the inclusion criteria.…”

Section: Trial Characteristicsmentioning

confidence: 99%

A Meta-analysis of Etidronate for the Treatment of Postmenopausal Osteoporosis

Cranney

Guyatt

Krolicki

et al. 2001

Osteoporosis International

118

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The aim of the study was to review the effect of etidronate on bone density and fractures in postmenopausal women. We searched MEDLINE from 1966 to 1998, examined citations of relevant articles, and the proceedings of international osteoporosis meetings. We contacted osteoporosis investigators to identify additional studies, primary authors, and pharmaceutical industry sources for unpublished data. We included 13 trials that randomized women to etidronate or an alternative (placebo or calcium and/or vitamin D) and measured bone density for at least 1 year. For each trial, three independent reviewers assessed the methodologic quality and abstracted data. The data suggested a reduction in vertebral fractures with a pooled relative risk of 0.63 (95% CI 0.44 to 0.92). There was no effect on nonvertebral fractures (relative risk 0.99, (95% CI 0.69 to 1.42). Etidronate, relative to control, increased bone density after 1-3 years of treatment in the lumbar spine by 4.06% (95% CI 3.12 to 5.00), in the femoral neck by 2.35% (95% CI 1.66 to 3.04) and in the total body by 0.97% (95% CI 0.39 to 1.55). Effects were larger at 4 years, though the number of patients followed much smaller. Etidronate increases bone density in the lumbar spine and femoral neck for up to 4 years. The pooled estimates of fracture reduction with etidronate suggest a reduction in vertebral fractures, but no effect on nonvertebral fractures.

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Section: Trial Characteristicsmentioning

confidence: 99%

A Meta-analysis of Etidronate for the Treatment of Postmenopausal Osteoporosis

Cranney

Guyatt

Krolicki

et al. 2001

Osteoporosis International

118

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“…Outcome Measures.\p=m-\Clinical and family histories of disease, particularly osteoporosis; oral contraceptive use; bone mineral densities of the spine, forearm, and total body by dual-and single-photon absorptiometry; estimates of nutrient intake by repeated 7-day diet diaries; and measures of physical activity using a physical activity monitor. Results.\p=m-\Themedian gain in bone mass for the third decade of life, expressed as a percentage per decade, was 4.8% for the forearm, 5.9% for lumbar bone mineral content, 6.8% for lumbar bone mineral density, and 12.5% for total body bone mass (P<.0001 in all cases). By both bivariate and multiple regression analysis the rate of gain in bone density of the spine was negatively correlated with age and positively correlated with calcium/protein intake ratio and physical activity (multiple r=.31 P=.004 …”

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confidence: 97%

Bone Gain in Young Adult Women

Recker¹,

Davies

Hinders

et al. 1992

JAMA

620

152

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Gain in bone mass occurs in healthy young women during the third decade of life. Physical activity and dietary calcium intake both exert a positive effect on this bone gain. Use of oral contraceptives exerts a further independent positive effect. Changes in life-style among college-aged women, involving relatively modest increases in physical activity and calcium intake, may significantly reduce the risk of osteoporosis late in life.

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Cyclic therapy of osteoporosis with neutral phosphate and brief, high-dose pulses of etidronate

Cited by 2 publications

References 0 publications

A Meta-analysis of Etidronate for the Treatment of Postmenopausal Osteoporosis

A Meta-analysis of Etidronate for the Treatment of Postmenopausal Osteoporosis

Bone Gain in Young Adult Women

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