Cyclic sulfonamides via the ring-closing metathesis reaction

Synthesis of Novel Anti-Bacterial 2,1-Benzothiazine 2,2-Dioxides Derived From Methyl Anthranilate

“…6 -benzo[c] [1,2] thiazin-4-ylidene)-hydrazines and their evaluation for antibacterial potential is reported. Some of the synthesized compounds have shown good anti-bacterial activity and this study may be useful to synthesize more biologically active compounds through further derivatization.…”

“…Sulfonamides are well known for their enormous potential as pharmaceutical and agricultural agents due to their versatile nature of biological activities 1 while cyclic sulfonamides are important as chiral auxiliaries 2,3 and therapeutic compounds 4,5 . Among these, benzothiazines, due to their diverse biological activities are gaining much attention since the very first synthesis by Braun et al 6 .…”

“…Up till now, a large number of such compounds have been synthesized with significant antimicrobial activities 10,11 . In continuation of our on-going research on various biologically active benzothiazine derivatives [12][13][14] , synthesis of N-benzylidene-N ' -(1-methyl-2,2-dioxo-2,3-dihydro-1H-2λ 6 -benzo[c] [1,2]thiazin-4-ylidene)-hydrazines has been carried out to get a series of possible biologically active compounds. Besides, characterization of the newly synthesized compounds through spectroscopic techniques and single crystal X-ray analysis, these were also subjected to the preliminary evaluation for their anti-bacterial potential due to their carbohydrazide functionalities 10,11 .…”

Oxidation of 3,4-dialkyl substituted isothiazolium salts to 1,1-dioxides

“…4 The synthesis of such cyclic vinylsultams 2 by ring-closing metathesis (RCM) of vinylsulfonamide templates in the presence of Grubbs catalyst has been described. 5 Sultams 3 react with cyclopentadiene in stereoselective Diels-Alder reactions to yield endonorbornenyl sulfonamides as the major diastereomer. Ring-opening metathesis polymerization (ROMP) of these cycloadducts was applied to prepare oligomeric sulfonamides (Scheme 1) .…”

Asymmetric Synthesis of 3‐Substituted γ‐ and δ‐Sultams

“…Furthermore, sultams can be synthesised by intraor intermolecular Diels-Alder reactions [15] and ring-closing metathesis. [1a,16] In 1999, Hanson et al described the first synthesis of cyclic sulfonamides with metathesis reactions, [17] and a few years later they reported on the successful enantioselective synthesis of γ-sultams. [18] Moreover, Metz et al described the synthesis of bicyclic δ-sultams by intramolecular Diels-Alder reactions of vinylsulfonamides.…”