Cyclic reactions-mediated self-supply of H2O2 and O2 for cooperative chemodynamic/starvation cancer therapy

Zhang, Xiaojuan; He, Chuanchuan; Chen, Yan; Chen, Chen; Yan, Ruicong; Fan, Ting; Gai, Yongkang; Tan, Yang; Lu, Yao; Xiang, Guangya

doi:10.1016/j.biomaterials.2021.120987

Cited by 64 publications

(41 citation statements)

References 32 publications

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“…Such strategies can be roughly outlined into TME modulation, usage of external stimuli, utilization of chemical and biological stimuli, and design of the nanoplatforms (Table 1). [ 16,17,22,34–36,40,43–105 ]…”

Section: Strategies To Enhance Chemodynamic Therapymentioning

confidence: 99%

“…FePt-FeC heterostructure CDT/NAD + depletion 4T1 [80] Chemical and biological stimuli Gas FeS@BSA nanocluster CDT/Gas therapy Huh7 [81] UCNPs@dMSN-SNO@CuO 2 -Ce6-PEG CDT/PDT/Gas therapy U14 [82] FeCO-MnO 2 @MSN CDT/Chemodynamic gas therapy 4T1 [83] MnS@BSA CDT/Gas therapy 4T1 [84] Nutrition GOx-Fe 3 O 4 -HMSNs-PFC/O 2 @C CDT/Starvation therapy B16F10 [85] PCN-224(Cu)-GOD@MnO 2 CDT/Starvation therapy U14 [86] LipoCaO 2 /Fe(OH) 3 -GOx CDT/Starvation therapy MDA-MB-231 [87] MCDION-Se (Nano-Se, MnCO Cu-TBP MOF CDT/PDT/Immunotherapy B16F10 [91] Gene silencing AIO RNAi nanoparticles CDT/Gene therapy PC3 [92] FeCysPW@ZIF-82@CATDz CDT/Gene therapy HeLa [93] Material design…”

Section: Tme Modulation Ph Modulationmentioning

confidence: 99%

“…[ 108 ] Recently, Xiang and coworkers prepared a nanocomposite (LipoCaO 2 /Fe(OH) 3 ‐GOx) by co‐loading GOx and CaO 2 /Fe(OH) 3 in a biocompatible liposome (Figure 7A). [ 87 ] Acidic TME can decompose CaO 2 /Fe(OH) 3 nanostructure to generate H 2 O 2 and Fe 3+ for triggering the Fenton reaction. The evolved O 2 as a byproduct can enhance the catalytic efficacy of GOx for the consumption of glucose to produce gluconic acid and H 2 O 2 , contributing to the elevated •OH production in CDT.…”

Section: Strategies To Enhance Chemodynamic Therapymentioning

confidence: 99%

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Strategies for enhancing cancer chemodynamic therapy performance

2022

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Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen species‐based cancer treatment modalities. CDT utilizes endogenous H2O2 in tumor microenvironment (TME) to produce cytotoxic hydroxyl radicals (•OH) via Fenton or Fenton‐like reactions. While possessing advantages such as tumor specificity, no need of external stimuli, and low side effects, practical applications of CDT are still impeded owing to the heterogeneity, complexity, and reductive environment of TME. Over the past couple of years, strategies to enhance CDT for efficient tumor regression are in rapid development in synergy with the growth of nanomedicine. In this review, we initially outline the fundamental understanding of Fenton and Fenton‐like reactions and their relationship with CDT. Subsequently, the development in the design of nanosystems for CDT is highlighted in a general manner. Furthermore, recent advancement of the strategies to augment Fenton reactions in TME for enhanced CDT is discussed in detail. Finally, perspectives toward the future development of CDT for better therapeutic outcome are presented. This review is expected to draw attention for collaborative research on CDT in the best interest of its future clinical applications.

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Section: Strategies To Enhance Chemodynamic Therapymentioning

confidence: 99%

Section: Tme Modulation Ph Modulationmentioning

confidence: 99%

Section: Strategies To Enhance Chemodynamic Therapymentioning

confidence: 99%

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Strategies for enhancing cancer chemodynamic therapy performance

2022

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“…Because of poor immune escape capacity and rapid elimination of these nanoparticles from the bloodstream by the action of liver and kidney organs, their transfer effect and anti-tumor efficacy are significantly diminished ( Zheng et al, 2018 ; Yin et al, 2019 ; Chen G. et al, 2020 ). Although liposomes and other drug delivery systems have achieved greater efficacy in tumor treatment in recent years, drug delivery systems also face interference and a series of biological barrier effects, such as the clearance of liver and kidney systems, cell resistance to foreign drugs and so on ( Yong et al, 2019 ; Yang et al, 2020 ; Wang et al, 2021 ; Zhang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Injectable Hydrogel for Synergetic Low Dose Radiotherapy, Chemodynamic Therapy and Photothermal Therapy

Mingzhu

Wang

Suo

et al. 2021

Front. Bioeng. Biotechnol.

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Higher doses of radiotherapy (RT) are associated with resistance induction, therefore highly selective and controllable radiosensitizers are urgently needed. To address this issue, we developed a FeGA-based injectable hydrogel system (FH) that can be used in combination with low-dose radiation. Our FH can deliver FeGA directly to the tumor site via intratumoral injection, where it is a reservoir-based system to conserve FeGA. The photothermal properties of FeGA steadily dissolve FH under laser irradiation, and, simultaneously, FeGA reacts with a large amount of H2O2 in the cell to produce OH (Fenton reaction) which is highly toxic to mitochondria, rendering the cell inactive and reducing radiotherapy resistance. In vivo and in vitro studies suggest that combining the FH and NIR irradiation with RT (2Gy) can significantly reduce tumor proliferation without side effects such as inflammation. To conclude, this is the first study to achieve combined chemodynamic therapy (CDT) and photothermal therapy (PTT) in situ treatment, and the best therapeutic effect can be obtained with a low-dose radiation combination, thus expanding the prospects of FeGA-based tumor therapy.

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“…In TME, Fe 2+ can react with enough hydrogen peroxide (H 2 O 2 ), thus producing toxic •OH. Several other kinds of iron-containing formulations such as tetraned iron nanoparticles, iron oxide nanoparticles, and FeGA particles have been utilized as a catalyst for Fenton-reacted cell death, either alone or in combination with other catalysts (16,17). Liu et al used food acid and Fe 2+ mixed ultra-small FeGA complex for achieving improved CDT (18).…”

Section: Introductionmentioning

confidence: 99%

An Injectable Hydrogel for Enhanced FeGA-Based Chemodynamic Therapy by Increasing Intracellular Acidity

et al. 2021

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Hydroxyl radical (•OH)-mediated chemodynamic therapy (CDT) is an emerging antitumor strategy, however, acid deficiency in the tumor microenvironment (TME) hampers its efficacy. In this study, a new injectable hydrogel was developed as an acid-enhanced CDT system (AES) for improving tumor therapy. The AES contains iron–gallic acid nanoparticles (FeGA) and α-cyano-4-hydroxycinnamic acid (α-CHCA). FeGA converts near-infrared laser into heat, which results in agarose degradation and consequent α-CHCA release. Then, as a monocarboxylic acid transporter inhibitor, α-CHCA can raise the acidity in TME, thus contributing to an increase in ·OH-production in FeGA-based CDT. This approach was found effective for killing tumor cells both in vitro and in vivo, demonstrating good therapeutic efficacy. In vivo investigations also revealed that AES had outstanding biocompatibility and stability. This is the first study to improve FeGA-based CDT by increasing intracellular acidity. The AES system developed here opens new opportunities for effective tumor treatment.

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Cyclic reactions-mediated self-supply of H2O2 and O2 for cooperative chemodynamic/starvation cancer therapy

Cited by 64 publications

References 32 publications

Strategies for enhancing cancer chemodynamic therapy performance

Strategies for enhancing cancer chemodynamic therapy performance

Injectable Hydrogel for Synergetic Low Dose Radiotherapy, Chemodynamic Therapy and Photothermal Therapy

An Injectable Hydrogel for Enhanced FeGA-Based Chemodynamic Therapy by Increasing Intracellular Acidity

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