Cyclic Peptide-Capped Gold Nanoparticles for Enhanced  siRNA Delivery

Shirazi, Amir Nasrolahi; Paquin, Karissa L.; Howlett, Niall G.; Mandal, Dindyal; Parang, Keykavous

doi:10.3390/molecules190913319

Cited by 36 publications

(40 citation statements)

References 35 publications

(46 reference statements)

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“…Many researchers have reported that cell surface GRP78 could promote invasion and metastasis of tumor cells and that blockade of cell surface GRP78 could reverse this effect. 26,27 Recent investigations 10,11,15 have revealed that specific mole cules targeting cell surface agents could administrate entry and subsequent cytosolic access of NPs into living cells, for example, carbohydrate, folic acid, transferrin, and some peptides. From Figure 3, we can see that GRP78 is more highly expressed on the cell surface of SMMC-7721 cells than on the cell surface of PLC cells, and many studies [23][24][25] have shown that GRP78 plays an important role in tumor cells' invasion and metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, researchers have found that some specific molecules used as targeting agents, such as carbohydrate, 10 folic acid, 11,12 transferrin, 13,14 and some peptides, 15,16 could be modified onto the surface of NPs and achieve active targeting therapy with high specificity, selectivity, and affinity through coupling targeting molecules with their specific receptor expressed on the cell surface.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78

Zhao¹,

Li²,

Shi³

et al. 2014

IJN

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Nanoparticles (NPs) which target specific agents could effectively recognize the target cells and increase the stability of chemical agents by encapsulation. As such, NPs have been widely used in cancer treatment research. Recently, over 90% of treatment failure cases in patients with metastatic cancer were attributed to resistance to chemotherapy. Surface-exposed glucose-regulated protein of 78 kDa (GRP78) is expressed highly on many tumor cell surfaces in many human cancers and is related to the regulation of invasion and metastasis. Herein, we report that NPs conjugated with antibody against GRP78 (mAb GRP78-NPs) inhibit the adhesion, invasion, and metastasis of hepatocellular carcinoma (HCC) and promote drug delivery of 5-fluorouracil into GRP78 high-expressed human hepatocellular carcinoma cells. Our new findings suggest that mAb GRP78-NPs could enhance drug accumulation by effectively transporting NPs into cell surface GRP78-overexpressed human hepatocellular carcinoma cells and then inhibit cell proliferation and viability and induce cell apoptosis by regulating caspase-3. In brief, mAb GRP78-NPs effectively inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78

Zhao¹,

Li²,

Shi³

et al. 2014

IJN

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“…However, for the latter, the noncovalent strategy for cargo and carrier has been used less often than the covalent one. CPPs could also be used to enhance other drug delivery systems such as polymer-based systems (e.g., micelles, dendrimers), liposomes , and inorganic carriers such as gold-, silver-, and ironbased nanoparticles (superparamagnetic iron oxide nanoparticles) (Wagner et al, 2009;Shirazi et al, 2014;Zuo et al, 2014), and quantum dots (Delehanty et al, 2006;Liu et al, 2011Liu et al, , 2013aMartin et al, 2013). Most nanoparticles provide binding sites for different cargos and targeting peptides which can be used for diagnostics and therapy.…”

Section: Formation Of Carrier-cargo Complexesmentioning

confidence: 99%

Viral and Other Cell-Penetrating Peptides as Vectors of Therapeutic Agents in Medicine

Durzyńska

Przysiecka

Nawrot

et al. 2015

J Pharmacol Exp Ther

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Efficient delivery of heterologous molecules for treatment of cells is a great challenge in modern medicine and pharmacology. Cellpenetrating peptides (CPPs) may improve efficient delivery of a wide range of macromolecular cargos, including plasmid DNA, small interfering RNA, drugs, nanoparticulate pharmaceutical carriers, and anticancer drugs. In this paper, we present the history of CPPs' discovery with special attention drawn to sequences of viral origin. We also describe different CPP families with regard to their physicochemical properties and numerous mechanisms of CPP cell uptake by direct penetration and endocytotic pathways. A detailed description is focused on formation of carrier-cargo complexes, which are needed for practical use of CPPs in medicine and biotechnology. Examples of successful application of CPPs in treatment of human diseases are also presented, including decreased tumor growth and induction of cancer cell death. Finally, we review modern design approaches to novel CPPs and prediction of their activity. To sum up, the current review presents a thorough and up-to-date knowledge of CPPs and may be a valuable source of information for researchers in pharmacology designing new therapeutic agents.

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“…NPs, as a nanoscale carrier, showed excellent value and potential for improving drug delivery. As their particle sizes range from 10 to 500 nm, drug-loaded NPs can be selectively retained at the tumor site (known as the EPR effect), and they can conjugate specific targeting molecules at the NPs’ surface to achieve active targeted therapy by binding with specific cell-surface receptors [29, 30]. In addition, the internalization of some NPs could specifically occur at the mitochondria, thus increasing ROS generation and enhancing synergistic antitumor efficacy by activating mitochondrial-meditated apoptosis [31, 32].…”

Section: Discussionmentioning

confidence: 99%

Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44

et al. 2017

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BackgroundA targeted drug nanoparticle (NP) delivery system has shown potential as a possible cancer treatment. Given its merits, such as its selective distribution at tumor sites and its controllable drug release, drug-loaded NPs can be effectively delivered to selected organs and targeted cells, thus enhancing its antitumor efficiency and reducing its toxicity.MethodsWe reported that hyaluronic acid (HA)-coated chitosan NPs promoted the drug delivery of 5-fluorouracil (5-Fu) into tumor cells that highly expressed CD44.ResultsOur new findings suggested that HA-coated chitosan NPs enhanced drug accumulation by effectively transporting NPs into CD44-overexpressed tumor cells, and they also resulted in mitochondrial damage induced by the production of reactive oxygen species (ROS). Compared to free drug and uncoated NPs, HA-coated chitosan NPs exhibited stronger inhibition rates and induced obvious apoptosis in CD44-overexpressed A549 cells.ConclusionsBiocompatible and biodegradable HA-coated chitosan NPs were developed to encapsulate a chemotherapeutic drug (5-Fu) to enhance drug accumulation in tumor cells and to improve the agent’s antitumor efficiency by offering targeted drug delivery via CD44.

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Cyclic Peptide-Capped Gold Nanoparticles for Enhanced siRNA Delivery

Cited by 36 publications

References 35 publications

Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78

Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78

Viral and Other Cell-Penetrating Peptides as Vectors of Therapeutic Agents in Medicine

Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44

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