Cyclic Nucleotide Phosphodiesterase Isoenzymes and Asthma — Outstanding Issues

Cd, Nicholson

doi:10.1007/978-3-0348-7324-6_1

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Cited by 2 publications

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“…Ein weiterer Schwerpunkt der physiologischen Grundlagenforschung glatter Muskulatur besteht in der Regulation der glatten Muskulatur des Bronchialbaumes. Sowohl im Tiermodell als auch beim Menschen scheinen hier der cAMP-spezifischen PDE IV sowie der cGMP-inhibierten PDE III eine besondere funktionelle Bedeutung zuzukommen [12,28], wobei der zusätzliche antiinflammatorische Effekt einer PDE IV-Inhibition einen synergistischen Effekt bei der Behandlung des Asthma bronchiale darstellen könnte [18].…”

Section: Diskussionunclassified

Identifizierung verschiedener Phosphodiesterase-Isoenzyme in der humanen Detrusormuskulatur

Truß¹,

Ückert²,

Stief³

et al. 1996

Aktuel Urol

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Section: Diskussionunclassified

Identifizierung verschiedener Phosphodiesterase-Isoenzyme in der humanen Detrusormuskulatur

Truß¹,

Ückert²,

Stief³

et al. 1996

Aktuel Urol

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Correlations of PDE-4 inhibition between enzymes of smooth muscle and inflammatory cell sources

Cariuk

Cavalla

Chasin³

et al. 1998

Cell Biochem Biophys

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The sensitivities of PDE-4 enzymes from smooth muscle and inflammatory cell sources from different species to a range of structurally diverse compounds were compared. All inflammatory cell PDE-4 sources displayed good crosscorrelations in their sensitivity to inhibition by these compounds. Similarly, PDE-4 enzymes from smooth muscle sources were well-correlated; however, there was no crosscorrelation between PDE-4 from smooth muscle sources and those of inflammatory cell sources, possibly reflecting differences in subcellular location of enzymes as well as subtype expression. The present study concludes that PDE-4 preparations from smooth muscle sources as well as those from inflammatory cell sources may be used to model the potential smooth muscle cell relaxing properties and anti-inflammatory properties of a compound in relation to human asthma.

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Cyclic Nucleotide Phosphodiesterase Isoenzymes and Asthma — Outstanding Issues

Cited by 2 publications

References 22 publications

Identifizierung verschiedener Phosphodiesterase-Isoenzyme in der humanen Detrusormuskulatur

Identifizierung verschiedener Phosphodiesterase-Isoenzyme in der humanen Detrusormuskulatur

Correlations of PDE-4 inhibition between enzymes of smooth muscle and inflammatory cell sources

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