Cyclic lipopeptides as antibacterial agents – Potent antibiotic activity mediated by intriguing mode of actions

Schneider, Tanja; Müller, Anna; Miess, Henrike; Gross, Harald

doi:10.1016/j.ijmm.2013.08.009

Cited by 98 publications

(66 citation statements)

References 81 publications

(84 reference statements)

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“…These compounds include Friulimicin produced by Actinoplanes friuliensis [80], Amphomycin produced by Streptomyces canus [81] and Laspartomycin produced by S.…”

Section: Biosynthesis Of Lipopeptide Surfactantsmentioning

confidence: 99%

Lipopeptide surfactants: Production, recovery and pore forming capacity

2015

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“…These compounds include Friulimicin produced by Actinoplanes friuliensis [80], Amphomycin produced by Streptomyces canus [81] and Laspartomycin produced by S.…”

Section: Biosynthesis Of Lipopeptide Surfactantsmentioning

confidence: 99%

Lipopeptide surfactants: Production, recovery and pore forming capacity

2015

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“…These lipopeptides are composed of a long hydrophobic alkyl chain linked to a cyclic polypeptide backbone [4]. The amino acids in the peptide backbone are frequently Disomers and unnatural amino acids-presumably to resist the activity of proteases [5]. These lipopeptides directly interact with the plasma membrane of pathogens and disrupt their lipid bilayer.…”

Section: Introductionmentioning

confidence: 99%

Structural characterization and temperature-dependent production of C17-fengycin B derived from Bacillus amyloliquefaciens subsp. plantarum BC32-1

Nam

Jung

Kim

et al. 2015

Biotechnol Bioproc E

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Cyclic lipopeptides were produced by Bacillus amyloliquefaciens subsp. plantarum strain BC32-1 that was isolated from yellow loess soil in the Jeonnam province of South Korea. Several lipopeptides were isolated from the bacteria using organic solvent extraction and reverse-phase high-performance liquid chromatography (RP-HPLC). Purified iturin-, surfactin-, and fengycin-type lipopeptides were identified using liquid chromatographymass spectrometry (LC-MS) analysis. Among the lipopeptides, C 17 -fengycin B showed strong antifungal activity against the phytopathogenic fungus, Fusarium oxysporum f. sp. radicis-lycopersici, and then the fengycin was further characterized by UV, Fourier transform-infrared spectroscopy (FT-IR), and LC-MS/MS analyses. C 17 -fengycin B was highly produced at quantities of up to 15 µg/mL at 37 o C, whereas little amount of the fengycin was produced at 25 o C. Purified C 17 -fengycin B inhibited mycelial growth of F. oxysporum with a minimal inhibitory concentration of 50 µg/mL. This study suggests that C 17 -fengycin B is a major antifungal component produced by the BC32-1 strain that could be used as an environmentally friendly agent to control the phytopathogenic F. oxysporum.

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“…Notable in this regard are the calcium‐dependent antibiotics (CDAs), which have gained clinical prominence owing to their activity against multi‐drug‐resistant pathogens 3, 4, 5. While a variety of antibacterial mechanisms have been ascribed to the various CDAs, an atomic‐level understanding of the recognition of their bacterial target(s) remains elusive.…”

mentioning

confidence: 99%

A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C

et al. 2017

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The calcium‐dependent antibiotics (CDAs) are an important emerging class of antibiotics. The crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl‐phosphate at a resolution of 1.28 Å is reported. This is the first crystal structure of a CDA bound to its bacterial target. The structure is also the first to be reported for an antibiotic that binds the essential bacterial phospholipid undecaprenyl phosphate (C55‐P). These structural insights are of great value in the design of antibiotics capable of exploiting this unique bacterial target.

show abstract

Cyclic lipopeptides as antibacterial agents – Potent antibiotic activity mediated by intriguing mode of actions

Cited by 98 publications

References 81 publications

Lipopeptide surfactants: Production, recovery and pore forming capacity

Lipopeptide surfactants: Production, recovery and pore forming capacity

Structural characterization and temperature-dependent production of C17-fengycin B derived from Bacillus amyloliquefaciens subsp. plantarum BC32-1

A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C

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