Cyclic lipopeptides and other bioactive secondary metabolites from a new terrestrial Streptomyces sp. TN272

Elleuch, Lobna; Shaaban, Khaled A.; Abdel‐Aziz, Mohamed S.; Chakchouk, Ahlem; Nagia, Mohamed; Mellouli, Lotfi; Shaaban, Mohamed

doi:10.5897/ajmr11.808

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…It was recently identified as an antimicrobial compound from Streptomyces spp. (Elleuch et al, 2012 ; Saravana Kumer et al, 2014 ) and from plants (Rangel-Sánchez et al, 2014 ). Butylated hydroxytoluene has previously been extracted from plants and approved by the FDA of the United States as a commercial fungicide (Torres et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

The Shewanella algae strain YM8 produces volatiles with strong inhibition activity against Aspergillus pathogens and aflatoxins

Gong

et al. 2015

Front. Microbiol.

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Aflatoxigenic Aspergillus fungi and associated aflatoxins are ubiquitous in the production and storage of food/feed commodities. Controlling these microbes is a challenge. In this study, the Shewanella algae strain YM8 was found to produce volatiles that have strong antifungal activity against Aspergillus pathogens. Gas chromatography-mass spectrometry profiling revealed 15 volatile organic compounds (VOCs) emitted from YM8, of which dimethyl trisulfide was the most abundant. We obtained authentic reference standards for six of the VOCs; these all significantly reduced mycelial growth and conidial germination in Aspergillus; dimethyl trisulfide and 2,4-bis(1,1-dimethylethyl)-phenol showed the strongest inhibitory activity. YM8 completely inhibited Aspergillus growth and aflatoxin biosynthesis in maize and peanut samples stored at different water activity levels, and scanning electron microscopy revealed severely damaged conidia and a complete lack of mycelium development and conidiogenesis. YM8 also completely inhibited the growth of eight other agronomically important species of phytopathogenic fungi: A. parasiticus, A. niger, Alternaria alternate, Botrytis cinerea, Fusarium graminearum, Fusarium oxysporum, Monilinia fructicola, and Sclerotinia sclerotiorum. This study demonstrates the susceptibility of Aspergillus and other fungi to VOCs from marine bacteria and indicates a new strategy for effectively controlling these pathogens and the associated mycotoxin production during storage and possibly in the field.

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Section: Discussionmentioning

confidence: 99%

The Shewanella algae strain YM8 produces volatiles with strong inhibition activity against Aspergillus pathogens and aflatoxins

Gong

et al. 2015

Front. Microbiol.

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“…[2][3][4][5] Actinomycetes have attracted the attention of many industrial and academic research groups attributable to their diversity and proven ability to produce many bioactive metabolites, antitumor agents, enzymes of industrial interest [6][7][8][9] and antibiotics, [10] especially from Streptomyces and Nocardiopsis species. [11][12][13] As a part of our continuous screening program for new bioactive secondary metabolites from actinomycetes, [14][15][16][17][18] the strain of Nocardiopsis sp.…”

Section: Introductionmentioning

confidence: 99%

New naturally occurring phenolic derivatives from marine Nocardiopsis sp. AS23C: Structural elucidation and in silico computational studies

Eliwa

Frese

Halawa

et al. 2019

Vietnam Journal of Chemistry

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In our persistent research for new bioactive secondary metabolites from marine actinomycetes, Nocardiopsis sp. AS23C strain was isolated from the marine Alga Sargassum arnaudianum collected in the Red Sea at Hurghada coast, Egypt. A large-scale fermentation of the strain on M2 medium containing 50% sea water, followed by fractionation and purification of the obtained extract afforded a new phenolic acid derivative, 4-amino-6-methylsalicylic acid (1a), together with 5-methylresorcinol (2) and linoleic acid (3). Their molecular structures were proved through the sophisticated spectroscopic analyses including exhaustive 1D and 2D NMR (1 and 2-Dimensional Nuclear Magnetic Resonance) as well mass spectroscopy techniques. The extract exhibited antibacterial activity against the Gram-positive Staphylococcus aureus, Bacillus subtilis ATCC6051, and Streptomyces viridochromogenes Tü 57. An in vitro cytotoxicity assaying of 1a and 2 against the human cervix carcinoma cell line (KB-3-1), pronounced no obvious activity. Additionally, in silico predictions of physicochemical properties, ADME (absorption, distribution, metabolism and excretion) parameters, acute oral toxicity and indication of toxicity targets were performed for 1a and 2 in comparison with the antioxidant agent orsellinic acid.

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Cyclic lipopeptides and other bioactive secondary metabolites from a new terrestrial Streptomyces sp. TN272

Cited by 2 publications

References 15 publications

The Shewanella algae strain YM8 produces volatiles with strong inhibition activity against Aspergillus pathogens and aflatoxins

The Shewanella algae strain YM8 produces volatiles with strong inhibition activity against Aspergillus pathogens and aflatoxins

New naturally occurring phenolic derivatives from marine Nocardiopsis sp. AS23C: Structural elucidation and in silico computational studies

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