Cyclic Ion Mobility for Hydrogen/Deuterium Exchange-Mass Spectrometry Applications
Damon Griffiths,
Malcolm Anderson,
Keith Richardson
et al.
Abstract:Hydrogen/deuterium exchange-mass spectrometry (HDX-MS) has emerged as a powerful tool to probe protein dynamics. As a bottom-up technique, HDX-MS provides information at peptide-level resolution, allowing structural localization of dynamic changes. Consequently, the HDX-MS data quality is largely determined by the number of peptides that are identified and monitored after deuteration. Integration of ion mobility (IM) into HDX-MS workflows has been shown to increase the data quality by providing an orthogonal m… Show more
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