Cyclic hydroxamic acids derived from α-amino acids 2. Regioselective synthesis, crystal structure, and antitumor activity of spiropiperidine-imidazolidine hydroxamic acids based on glycine and dl-alanine

Iron-chelating activity of synthesized spirocyclic hydroxamic acids, their toxicity, and effects on mitochondrial function were studied using primary culture of cerebral cortical neurons from newborn rats. All tested compounds effectively chelated Fe(II) ions. Activity of spirocyclic hydroxamic acids more strictly depended on the structure their piperidine, but not imidazolidine fragment. All compounds were non-toxic for normal neuronal culture.

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Biological Activity of Spirocyclic Hydroxamic Acids

Neganova

Мищенко

Serkova

et al. 2016

Bull Exp Biol Med

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Regioselective Synthesis, Structure, and Chemosensitizing Antitumor Activity of Cyclic Hydroxamic Acid Based on DL-Valine

et al. 2021

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Cyclic hydroxamic acids derived from α-amino acids 2. Regioselective synthesis, crystal structure, and antitumor activity of spiropiperidine-imidazolidine hydroxamic acids based on glycine and dl-alanine

Cited by 2 publications

References 18 publications

Biological Activity of Spirocyclic Hydroxamic Acids

Biological Activity of Spirocyclic Hydroxamic Acids

Regioselective Synthesis, Structure, and Chemosensitizing Antitumor Activity of Cyclic Hydroxamic Acid Based on DL-Valine

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