Cyclic guanidines. VII. Structure-activity relationships of hypoglycemic cyclic guanidines.

Kosasayama, Akira; Ishikawa, Fumiyoshi

doi:10.1248/cpb.27.1596

Cited by 8 publications

(4 citation statements)

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“…It could be easily replaced by their 5‐ and 6‐membered ring analogues. Compounds having hypoglycemic, 310 diuretic, 311 antilipidic peroxidation, 312 andantidyslipidemia 313 activities are displayed in Figure 39.…”

Section: Activity On Unknown Targetsmentioning

confidence: 99%

1,3‐Diazepine: A privileged scaffold in medicinal chemistry

Malki

Martinez

Masurier

2021

Medicinal Research Reviews

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Privileged structures have been widely used as effective templates for drug discovery. While benzo‐1,4‐diazepine constitutes the first historical example of such a structure, the 1,3 analogue is just as rich in terms of applications in medicinal chemistry. The 1,3‐diazepine moiety is present in numerous biological active compounds including natural products, and is used to design compounds displaying a large range of biological activities. It is present in the clinically used anticancer compound pentostatin, in several recent FDA approved β‐lactamase inhibitors (e.g., avibactam) and also in coformycin, a natural product known as a ring‐expanded purine analogue displaying antiviral and anticancer activities. Several other 1,3‐diazepine containing compounds have entered into clinical trials. This heterocyclic structure has been and is still widely used in medicinal chemistry to design enzyme inhibitors, GPCR ligands, and so forth. This review endeavours to highlight the main use of the 1,3‐diazepine scaffold and its derivatives, and their applications in medicinal chemistry, drug design, and therapy. We will focus more particularly on the development of enzyme inhibitors incorporating this scaffold, with a strong emphasis on the molecular interactions involved in the inhibition mechanism.

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Section: Activity On Unknown Targetsmentioning

confidence: 99%

1,3‐Diazepine: A privileged scaffold in medicinal chemistry

Malki

Martinez

Masurier

2021

Medicinal Research Reviews

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“…Pyrimido [1,2-a]pyrimidines are bicyclic guanidine-type heterocycles that bind to oxoanion species in open-chain artificial receptors, [388] and they function as hypoglycemic compounds [389]. Microwave irradiation has been shown to be beneficial for the synthesis of this class of compounds [390,391].…”

Section: Pyrimidine Derivativesmentioning

confidence: 99%

Recent Advances in Microwave-Assisted Synthesis of Heterocyclic Compounds

Molteni¹,

Ellis²

2005

COS

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“…The development of pyrimidopyrimidines as potential hosts in the enantioselective recognition of oxo anions in polytopic abiotic receptors [9] and anchor modules for oxo anionic functions of molecular guests species complexed by polytopic artificial receptors is also well documented [10] and gave an impetus for the chemistry of such system.…”

Section: Introductionmentioning

confidence: 99%