Cyclic expression of Lhx2 is involved in secondary hair follicle development in cashmere goat

Geng, Rong; Lan-ping, Wang; Wang, Xiaolong; Chen, Yulin

doi:10.1016/j.gep.2014.07.004

Cited by 17 publications

(15 citation statements)

References 26 publications

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“…LHX2 , a LIM homeobox gene, regulates the generation and regeneration of hair44. We have previously shown that the cyclic expression of LHX2 is involved in the development of SHF in cashmere goats45. FGF9 is able to promote hair follicle regeneration after wounding46, and the Wnt-related genes WNT2 is a key mediator and regulator of Wnt signaling, and is involved in hair follicle initiation47.…”

Section: Resultsmentioning

confidence: 99%

Whole-genome sequencing of eight goat populations for the detection of selection signatures underlying production and adaptive traits

Wang

Liu

Zhou

et al. 2016

Sci Rep

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The goat (Capra hircus) is one of the first farm animals that have undergone domestication and extensive natural and artificial selection by adapting to various environments, which in turn has resulted in its high level of phenotypic diversity. Here, we generated medium-coverage (9–13×) sequences from eight domesticated goat breeds, representing morphologically or geographically specific populations, to identify genomic regions representing selection signatures. We discovered ~10 million single nucleotide polymorphisms (SNPs) for each breed. By combining two approaches, ZHp and di values, we identified 22 genomic regions that may have contributed to the phenotypes in coat color patterns, body size, cashmere traits, as well as high altitude adaptation in goat populations. Candidate genes underlying strong selection signatures including coloration (ASIP, KITLG, HTT, GNA11, and OSTM1), body size (TBX15, DGCR8, CDC25A, and RDH16), cashmere traits (LHX2, FGF9, and WNT2), and hypoxia adaptation (CDK2, SOCS2, NOXA1, and ENPEP) were identified. We also identified candidate functional SNPs within selected genes that may be important for each trait. Our results demonstrated the potential of using sequence data in identifying genomic regions that are responsible for agriculturally significant phenotypes in goats, which in turn can be used in the selection of goat breeds for environmental adaptation and domestication.

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Section: Resultsmentioning

confidence: 99%

Whole-genome sequencing of eight goat populations for the detection of selection signatures underlying production and adaptive traits

Wang

Liu

Zhou

et al. 2016

Sci Rep

Self Cite

113

102

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“…The morphogenesis of wool follicles in Merino sheep is similar to those of cashmere goats [ 8 ]. Studies on wool follicle cycling and SF development in cashmere goats have identified a large number of genes related to follicle and fiber development in which the mechanism of SF development has been elucidated using high throughput RNA sequencing approach [ 9 , 10 , 11 , 12 ]. However, the morphogenesis and genes or signaling pathways that regulate fetal SF development and branching in Merino sheep require further investigation.…”

Section: Introductionmentioning

confidence: 99%

Effect of Nutritional Restriction on the Hair Follicles Development and Skin Transcriptome of Chinese Merino Sheep

Chen

et al. 2020

Animals

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The high concentration of secondary branched wool follicles is a distinctive feature of the Merino sheep. At present, the molecular control of the development and branching of secondary wool follicles (SF) remains elusive. To reveal the potential genes associated with the development of hair follicles, we investigated the characteristics of prenatal and postnatal development of wool follicles, and the transcriptional expression profile in fetuses/lambs from dams under either maternal maintenance or sub-maintenance (75% maintenance) nutrition. The density of SF and the ratio of SF to primary wool follicles (PF) were reduced (p < 0.05) in fetuses from day 105 to 135 of gestation under sub-maintenance nutrition. Differentially expressed genes were enriched in the binding, single-organism process, cellular process, cell and cell part Gene Ontology (GO) functional categories and metabolism, apoptosis, and ribosome pathways. Four candidate genes, SFRP4, PITX1, BAMBI, and KRT16, which were involved in secondary wool follicles branching and development, were identified. Our results indicate that nutritional intervention imposed on pregnant ewes by short-term sub-maintenance nutrition could provide a strategy for the study of wool follicle development. Overall insight into the global gene expression associated with SF development can be used to investigate the underlying mechanisms of SF branching in Merino sheep.

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“…Lately, the principal canonical pathways of the HF cycle were assessed also in cashmere goats [10,11]. Particularly, a recent works identified a strong signature of selection involved in cashmere production traits [12,13], confirming the role of some molecules engaged in the generation and regeneration of hair, such as Lhx2, implicated in the SHFs development [14], Fgf5, whose disruption in cashmere goats led to more secondary hair follicles and longer fibers [15] and the transcription factor Hoxc8, whose hypermethylation status of exon1 is correlated with shorter fleece length on cashmere goats [16]. However, in double-coated animals, some other uncommon pathways could be involved in the undercoat growth.…”

Section: Introductionmentioning

confidence: 90%

Shedding light on cashmere goat hair follicle biology: from morphology analyses to transcriptomic landascape

et al. 2020

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Background: Cashmere goat is known for its precious undercoat. Being photoperiod-dictated, cashmere growth has been studied focusing mainly on hair follicle cycle phases (anagen, catagen and telogen). An accurate molecular knowledge of the goat hair follicle cycle, disentangling gene expression changes during phases and recognizing timing boundaries, could be useful to improve cashmere goat management and ultimately cashmere production. Results: To better describe goat's hair follicle transcriptome we applied RNA-sequencing to isolated hair follicles from five Italian cashmere goats, during the anagen and catagen phase, identifying total of 214 differentially expressed genes (DEGs): 97 were up-regulated while 117 were down-regulated in catagen with respect to anagen. Gene Ontology and pathway analysis were performed. We detected 144 significant pathways spanning from estrogen, pluripotency of stem cells, thermogenesis and fatty acid metabolism that were strongly expressed during the hair follicle phases analysed. Finally, we validated promising DEGs by RT-qPCR in the same set of samples as well as in hair follicles and entire skin biopsies of another cashmere goats cohort accounting for early anagen, anagen, early catagen, and catagen phases. Conclusions: As in the isolated hair follicles, some target genes were homogenously modulated during the four hair follicle phases. Ceruloplasmin (CP) and Keratin 4 (K4), confirmed their clear cut expression between growing and resting phase. In fact, K4 was almost absent in catagen phases while CP was barely expressed in anagen phases. In particular, the strong expression of K4 in early anagen makes it an eligible marker to track the beginning of a new hair cycle, and therefore defining the optimum time for cashmere harvesting.

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Cyclic expression of Lhx2 is involved in secondary hair follicle development in cashmere goat

Cited by 17 publications

References 26 publications

Whole-genome sequencing of eight goat populations for the detection of selection signatures underlying production and adaptive traits

Whole-genome sequencing of eight goat populations for the detection of selection signatures underlying production and adaptive traits

Effect of Nutritional Restriction on the Hair Follicles Development and Skin Transcriptome of Chinese Merino Sheep

Shedding light on cashmere goat hair follicle biology: from morphology analyses to transcriptomic landascape

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