The squirrel monkey uterine cervix was studied macroscopically and microscopically in intact and ovariectomized monkeys. The effect in ovariectomized monkeys of estradiol dipropionate or progesterone of both given after estrogen priming was studied by PAS staining,The lower portion of the cervix was dilated to form a vestibule into which projected fibromuscular colliculi which arose from the isthmic end of the cervix. The stratified squamous epithelium of the vagina was continuous through the external 0s with a similar epithelium lining the vestibule and covering the external surfaces of the colliculi. The transitional zone between the stratified epithelium and columnar cells was variable. The colliculi were covered internally with mucosal folds of columnar epithelium continuous with those of the endocervical canal.Glycogen concentration in the smooth muscle did not fluctuate markedly, inespective of the hormones used. Glycogen granules were more numerous in the stratified squamous epithelium. Malt-diastase-resistant material appeared to be more abundant in the columnar epithelium and glandular lumina when the monkeys received both hormones than when they received solely estrogen or progesterone.Recently the New World primate Saimiri sciureus, or common squirrel monkey, has become a popular research animal for diverse experimental procedures. Studies are being pursued to determine its usefulness as a laboratory animal model for investigations of metaplastic and neoplastic alterations of the cervix uteri. Microscopic investigation of the squirrel monkeys cervix uteri has been notably difficult, however, because of its complicated morphology in this primate. It was felt that a study of the normal morphology of the organ was warranted and that preliminary studies of the response (morphologic and PAS reaction) of the cervix uteri to ovarian hormones might also prove to be of value to other investigators.
MATERIALS AND METHODSThe cervices uteri of seven adult female squirrel monkeys were fixed in 10% formalin and dissected under a binocular dissecting microscope. A sagittal incision was made through the anterior or posterior wall of the organ to expose the internal features of the cervix. The cervix uteri of an eighth monkey which exsanguinated at parturition was similarly studied. The J. MORPH., 122: 81-88.