Cyclic AMP regulates expression of the gene coding for a mouse vas deferens protein related to the aldo-keto reductase superfamily in human and murine adrenocortical cells

Aigueperse, Christelle; Martinez, A; Lefrançois‐Martinez, Anne‐Marie; Veyssière, G.; Jean, C

doi:10.1677/joe.0.1600147

Cited by 42 publications

(37 citation statements)

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“…Subsequently, a high level of expression was reported in the zona fasciculata of the adrenal cortex (Lau et al 1995, Aigueperse et al 1999 in ovaries following stimulation with a luteinizing hormone (LH) analog (Brockstedt et al 2000) and, to a lesser extent, in several other organs, e.g., kidney, intestine, eye, and seminal vesicle (Lau et al 1995). Extensive investigation of the gene's transcriptional regulation found the vas deferens expression to be androgen-dependent (Taragnat et al 1988, Martinez et al 2001 and similarly, adrenal expression was found to be dependent on corticotrophin (adrenocorticotrophin (ACTH); Lefrancois-Martinez et al 1999, Martinez et al 2001.…”

Section: Introductionmentioning

confidence: 99%

“…AKR1B7 protein is only detectable within a timeframe of 1.5-14 h after hCG treatment, thus suggesting an important role for this AKR in ovulatory processes (Brockstedt et al 2000). The promoter region of Akr1b7 has been shown to contain two sequence motives with high homology to the cAMP response element (Aigueperse et al 1999). The rapid induction of Akr1b7 mRNA within 1.5 h post-hCG might, therefore, be a direct effect of cAMP on the promoter (ACTH as well as LH exert their actions mainly via cAMP).…”

Section: Introductionmentioning

confidence: 99%

“…The rapid induction of Akr1b7 mRNA within 1.5 h post-hCG might, therefore, be a direct effect of cAMP on the promoter (ACTH as well as LH exert their actions mainly via cAMP). Moreover, expression of Akr1b7 in the adrenal gland is dependent on transcription factors like NR5A1 (also known as SF1) and CCAAT/enhancer binding protein (C/EBP)-b (Aigueperse et al 1999), which are additionally involved in the regulation of expression of steroidogenic genes.…”

Section: Introductionmentioning

confidence: 99%

“…It has, however, been shown that this high level of AKR1B7 expression is unique for the vas deferens of the mouse when compared with other rodent species (Taragnat et al 1990, Schnolzer et al 1992, Aigueperse et al 1999. The murine expression has been shown to be the result of a 77 bp LINE element-derived sequence insertion, which is specific to the murine AKR1B7 promoter and conveys androgen responsiveness.…”

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confidence: 99%

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AKR1B7 (mouse vas deferens protein) is dispensable for mouse development and reproductive success

Baumann¹,

Davies²,

Peters³

et al. 2007

Reproduction

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AKR1B7 (aldo-keto reductase family 1, member 7; also known as mouse vas deferens protein) is a member of the AKR superfamily, and has been suggested to play a role in detoxifying processes on account of its preferred substrates, 4-hydroxynonenal and isocaproaldehyde. High levels of protein expression were found in the vas deferens and the adrenal gland, where sustained expression is dependent on androgen or ACTH respectively. Recently, a remarkable induction of AKR1B7 expression has been reported in the ovary following exogenous injections of LH. In the present study, we confirm this regulation physiologically during the estrous cycle, observing Akr1b7 expression to be restricted to the theca and stromal cells of the proestrus ovary. To further investigate the role of this detoxifying enzyme in both male and female reproduction, we generated knockout mice deficient in AKR1B7. Although AKR1B7 expression in the vas deferens is considerable and tightly regulated in the ovary of wild-type animals, homozygous mutant animals were found to be viable and no reproductive phenotype was observed. Ovarian follicle maturation and spermatozoa parameters remained normal in the absence of this protein. The determination of serum progesterone revealed an increase in hormone concentration in metestrus, while progesterone was found to be decreased in the estrus phase of the cycle in knockout females.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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AKR1B7 (mouse vas deferens protein) is dispensable for mouse development and reproductive success

Baumann¹,

Davies²,

Peters³

et al. 2007

Reproduction

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“…Transcriptional regulation of Akr1b7 has been well defined in two of the major organs in which it is expressed. In mouse adrenal cortex, its expression is acutely regulated by ACTH (39), whereas in the mouse vas deferens, a strong androgen-dependent accumulation has been described (40). Lau et al have shown by RNase protection that Akr1b7 is also expressed in mouse kidney, eye, intestine and, to a very low extent, in liver (41).…”

Section: Discussionmentioning

confidence: 99%

Aldo-keto reductase 1 family B7 is the gene induced in response to oxidative stress in the livers of Long-Evans Cinnamon rats

Chen

Takahashi²,

Zhang³

et al. 2006

Int J Oncol

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Abstract. The Long-Evans Cinnamon (LEC) rat strain (Atp7b m/m), which accumulates copper in the liver due to mutations in the Atp7b gene, is a useful model for investigating the relationship between oxidative stress and hepatocarcinogenesis. To determine the effect of this mutation on oxidative stress marker genes, we performed oligonucleotide array analysis (Affymetrix), and compared the results in Atp7b m/m rats with those of a sibling line with the Atp7b w/w genotype. We focused our studies on the expression of the aldo-keto reductase 1 family B7 (AKR1B7)-like protein gene, since this gene codes for reductase enzymes involved in the detoxification of oxidizing compounds (e.g., aldehydes) and was differentially expressed in Atp7b m/m and Atp7b w/w rat liver. Akr1B7 mRNA expression was significantly increased in comparison with the expression of 4 other known oxidative stress responsive genes, haem-oxygenase-1 (HO-1), thioredoxin (Trx), aldehyde reductase (AKR1A1), and glucose-6-phosphate dehydrogenase (G6PDH). By searching binding motifs, five nuclear factor kappa B (NF-κB) binding sites were located in the 5'-upstream region of the Akr1b7 gene. Transient co-transfection with both I-κB· and the Akr1b7 6 kb promoter (p6.0-AKR-Luc) inhibited luciferase activity of p6.0-AKR-Luc in HepG2 cells. Cuprous ion however did not affect the transcription activity induced by p6.0-AKR-Luc. Gel-shift assay showed that the DNA binding activity of NF-κB increased in the livers of LEC rats, suggesting that the oxidative stress is mediated through NF-κB. The results indicate conclusively that in LEC rat liver, Akr1b7 might be up-regulated by oxidative stress mediated through NF-κB, but not that mediated directly by copper. IntroductionHepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and one of the most deadly cancers with approximately 600,000 yearly deaths (1). Hepatocarcinogenesis is a multi-step process and cellular oxidative stress is one of the factors responsible for the propagation of liver diseases, such as hepatitis, cirrhosis, and hepatoma (2-4). Although much is known about the cellular pathogenesis and etiological agents leading to HCC, the molecular events are not well understood. Recent advances in genomics and proteomics have had the potential to identify characteristics of HCC that may be related to prognosis or to etiology, and these may be useful in HCC screening or diagnosis. Here the Long-Evans Cinnamon (LEC) rat model provides a unique opportunity to unveil the early molecular event associated with oxidative stress-related hepatocarcinogenesis.The Long-Evans Cinnamon (LEC) rat strain, which accumulates copper in the liver due to mutations in the Atp7b gene, has been used as a model to investigate the relationship between oxidative stress and hepatocarcinogenesis (5-11). The hepatic levels of oxidative stress indicators in LEC rats were found to be elevated during the onset of fulminant hepatitis between 16 and 24 weeks of age, while the levels of antioxidants such as ascorbate and ubi...

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Acquisition of Androgen‐Mediated Expression of Mouse Vas Deferens Protein (MVDP) Gene in Cultured Epithelial Cells and in Vas Deferens During Postnatal Development

MANIN,

MARTINEZ,

van der SCHUEREN

et al. 2000

Journal of Andrology

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We used cultured vas deferens epithelial cells (VDECs) as a model system to determine the conditions that allow mouse vas deferens protein (MVDP) gene expression and acquisition of androgen responsiveness. On the basis of Northern blot analysis, the mvdp gene is constitutively expressed at very low levels in prepubertal VDECs grown on collagen‐coated plastic or on microporous membrane inserts. In the presence of dihydrotestosterone (DHT), mvdp messenger RNA levels dramatically increased in cells cultured on microporous membrane inserts and stayed unchanged in cells grown on matrix‐coated plastic. Epithelial cells derived from fetal vas deferens were able to synthesize MVDP in response to DHT, and the presence of fetal mesenchymal cells did not influence MVDP production. Providing the cells with a culture procedure that permits access to the basolateral membranes and caters to the polarity requirements of the cell is a prerequisite for androgen induction of MVDP gene expression. The results also point to a role for epidermal growth factor, insulin, and tyrosine kinase activity in mediating the action of androgen on mvdp gene expression. In vivo studies show that the first expression of the mvdp gene between 5 and 7 days postpartum is not associated with major structural changes in the epithelium. The acquisition of a mature phenotype by epithelial and peritubular contractile cells, between 10 and 20 days, correlates with androgen dependency of the mvdp gene. We propose that cell differentiation and polarization on a matrix‐coated microporous membrane reproduces some of the events that are necessary for acquisition of androgenic responsiveness of the mvdp gene during postnatal development.

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Cyclic AMP regulates expression of the gene coding for a mouse vas deferens protein related to the aldo-keto reductase superfamily in human and murine adrenocortical cells

Cited by 42 publications

References 40 publications

AKR1B7 (mouse vas deferens protein) is dispensable for mouse development and reproductive success

AKR1B7 (mouse vas deferens protein) is dispensable for mouse development and reproductive success

Aldo-keto reductase 1 family B7 is the gene induced in response to oxidative stress in the livers of Long-Evans Cinnamon rats

Acquisition of Androgen‐Mediated Expression of Mouse Vas Deferens Protein (MVDP) Gene in Cultured Epithelial Cells and in Vas Deferens During Postnatal Development

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