“…With its effects on monoamine transporters (Lucas et al, 2007), brain renin angiotensin system (RAS) (Wright et al, 2002), phosphodiesterase (Marcus et al, 1978), furosemide may enhance cyclic adenosine monophosphate-cAMP-response element binding protein-brain derived neurotrophic factor (cAMP-CREB-BDNF) signalling. In the peripheral nervous system, the actions of furosemide may overlap with that of cAMP (Kreydiyyeh et al, 2000). Furosemide's anti-oxidant actions (Lahet et al, 2003), its effect on cytokines (Yuengsrigul et al, 1999) and its attenuation of glutamate-mediated excitotoxicity (Sanchez-Gomez et al, 2011) enhances neuroplasticity.…”