CYCLIC AMP AND FUROSEMIDE STIMULATE THE Na+–K+ATPase IN ISOLATED RAT JEJUNAL CELLS

Kreydiyyeh, Sawsan Ibrahim

doi:10.1006/phrs.1999.0573

Cited by 8 publications

(6 citation statements)

References 20 publications

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“…When there is stimulation for acid secretion the concentrations of sodium increases and potassium decreases in the gastric mucosa (Feldman and Goldschmiedt, 1991;deBeus et al, 1993). This increase in intracellular sodium would in turn lead to an activation of the Na + K + ATPase (Kreydiyyeh, 2000) which was also observed in the study (Table 3, group II). A decrease in the activity of ATPases upon treatment with Pterocarpus santalinus resulted in a decrease of sodium ion and an increase in the potassium ion concentration, thus maintaining the functional integrity of cell membrane.…”

Section: Discussionsupporting

confidence: 54%

“…It is well known that the ATPases maintain cellular electrolyte concentrations and trans-membrane electrochemical gradient. Maintenance of the integrity of the mitochondrial membrane depends on the proper functioning of pumps such as H + K + ATPases, Na + K + ATPase and Ca 2+ ATPase in the gastric mucosal tissue (Kreydiyyeh, 2000). The increase in ATPases activity on ibuprofen induction could be due to the free radicals generated in the process, causing lipid peroxidation and alterations to membrane fluidity.…”

Section: Discussionmentioning

confidence: 99%

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Pterocarpus santalinus: a traditional herbal drug as a protectant against ibuprofen induced gastric ulcers

et al. 2005

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The ethanol extract of Pterocarpus santalinus (PS) was evaluated for gastroprotection in rats using ibuprofen as the induction model. Rats treated with PS (100-400 mg/kg) showed a significant reduction in gastric lesions. PS at a dose of 200 mg/kg was found to be the minimum effective dose and hence further studies with that dose were carried out. PS treatment increased the LDH activity and decreased the lipid peroxidation levels. The extract had the ability to increase the antioxidant enzymes SOD, CAT and GPx when compared with the untreated but induced rats. The membrane bound ATPases - H(+)K(+)ATPase, Na(+)K(+)ATPase and Ca(2+)ATPases were increased upon the induction with ulcerogen. The treated group showed a decrease in the activities of these enzymes and also had the ability to restore the sodium and potassium ion concentrations to near normal levels, which were altered by ibuprofen mediated acid stimulation. The results suggest that the antiulcer properties of PS could traced to its acid inhibiting potential, antioxidant activity and the ability to maintain functional integrity of the cell membranes.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Pterocarpus santalinus: a traditional herbal drug as a protectant against ibuprofen induced gastric ulcers

et al. 2005

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“…Rat Na + -K + -ATPase is phosphorylated in vitro by PKC predominantly at Ser-18 and by PKA at Ser-938 [Beguin et al, 1994]. The molecular mechanism of regulation is an open question, however, because seemingly inconsistent functional effects have been reported with different experimental systems, including either activation or inhibition ostensibly through the same kinase [Feschenko et al, 2000;Kreydiyyeh, 2000].…”

Section: Muscarinic-acetylcholine Receptor Activationmentioning

confidence: 99%

An Overview of Autonomic Regulation of Parotid Gland Activity: Influence of Orchiectomy

Busch

Sterin‐Borda

Borda

2006

Cells Tissues Organs

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The parotid gland participates in the digestive process by providing fluid, electrolytes and enzymes that facilitate the onset of digestion. Neurotransmitters, hormones and biologically active peptides regulate its activity. The autonomic system is the main regulatory mechanism of the gland. Sympathetic stimulation induces amylase release through β₁-receptor activation and few fluid secretion by α₁-receptor activation. The parasympathetic system controls basal activity of the gland acting on M₁ and M₃ muscarinic acetylcholine receptors and induces the secretion of fluid saliva rich in electrolytes through the modulation of ion channels and the Na⁺-K⁺-ATPase activity. In addition, its activation induces amylase release. The mechanisms involved in amylase secretion by isoproterenol and carbachol, as well as the mechanism of the cholinergic regulation of Na⁺-K⁺-ATPase activity and the changes observed after orchiectomy, are the scope of this review.

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“…With its effects on monoamine transporters (Lucas et al, 2007), brain renin angiotensin system (RAS) (Wright et al, 2002), phosphodiesterase (Marcus et al, 1978), furosemide may enhance cyclic adenosine monophosphate-cAMP-response element binding protein-brain derived neurotrophic factor (cAMP-CREB-BDNF) signalling. In the peripheral nervous system, the actions of furosemide may overlap with that of cAMP (Kreydiyyeh et al, 2000). Furosemide's anti-oxidant actions (Lahet et al, 2003), its effect on cytokines (Yuengsrigul et al, 1999) and its attenuation of glutamate-mediated excitotoxicity (Sanchez-Gomez et al, 2011) enhances neuroplasticity.…”

Section: Introductionmentioning

confidence: 99%

Effect of nifedipine, imipramine and sertraline on the antidepressant-like actions of furosemide in forced swim (FST) and tail suspension (TST) tests models of depression in mice

S.¹,

E.²

2012

Afr. J. Biotechnol.

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CYCLIC AMP AND FUROSEMIDE STIMULATE THE Na+–K+ATPase IN ISOLATED RAT JEJUNAL CELLS

Cited by 8 publications

References 20 publications

Pterocarpus santalinus: a traditional herbal drug as a protectant against ibuprofen induced gastric ulcers

Pterocarpus santalinus: a traditional herbal drug as a protectant against ibuprofen induced gastric ulcers

An Overview of Autonomic Regulation of Parotid Gland Activity: Influence of Orchiectomy

Effect of nifedipine, imipramine and sertraline on the antidepressant-like actions of furosemide in forced swim (FST) and tail suspension (TST) tests models of depression in mice

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