Cyclic alternating pattern and interictal epileptiform discharges during morning sleep after sleep deprivation in temporal lobe epilepsy

Giorgi, Filippo Sean; Maestri, Michelangelo; Guida, Melania; Carnicelli, Luca; Caciagli, Lorenzo; Ferri, Raffaele; Bonuccelli, Ubaldo; Bonanni, Enrica

doi:10.1016/j.yebeh.2017.05.005

Cited by 14 publications

(14 citation statements)

References 41 publications

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“…In epilepsy, the proper function of the BBB is altered, which results in abnormal function and seizures ( van Vliet et al , 2015 ; Rüber et al , 2018 ). Furthermore, sleep affects epileptiform activity ( Ellingson et al , 1984 ; Binnie and Stefan, 1999 ; Méndez and Radtke, 2001 ; Klein et al , 2003 ; Baldin et al , 2017 ; Giorgi et al , 2017 ) and BBB function ( Jessen et al , 2015 ; Cuddapah et al , 2019 ). Moreover, evidence has emerged that improper function of the BBB may cause epilepsy altogether ( Marchi et al , 2016 ) and contribute to drug resistance in epilepsy ( Liu et al , 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Respiratory-related brain pulsations are increased in epilepsy—a two-centre functional MRI study

Kananen

Helakari

Korhonen

et al. 2020

Brain Communications

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Resting state functional MRI has shown potential for detecting changes in cerebral blood oxygen level-dependent signal in patients with epilepsy, even in the absence of epileptiform activity. Furthermore, it has been suggested that coefficient of variation mapping of fast functional MRI signal may provide a powerful tool for identification of intrinsic brain pulsations in neurological diseases such as dementia, stroke, and epilepsy. In this study, we used fast functional MRI sequence (magnetic resonance encephalography) to acquire ten whole brain images per second. We used the functional MRI data to compare physiological brain pulsations between healthy controls (n = 102) and patients with epilepsy (n = 33), and furthermore to drug-naïve seizure patients (n = 9). Analyses were performed by calculating coefficient of variation and spectral power in full-band and filtered sub-bands. Brain pulsations in the respiratory-related frequency sub-band (0.11–0.51 Hz) were significantly (p<0.05) increased in patients with epilepsy, with an increase in both signal variance and power. At the individual level, over 80% of medicated and drug-naïve seizure patients exhibited areas of abnormal brain signal power that correlated well with the known clinical diagnosis, while none of the controls showed signs of abnormality with the same threshold. The differences were most apparent in the basal brain structures, respiratory centers of brain stem, midbrain, and temporal lobes. Notably, full-band, very low frequency (0.01-0.1 Hz) and cardiovascular (0.8-1.76 Hz) brain pulses showed no differences between groups. This study extends and confirms our previous results of abnormal fast functional MRI signal variance in epilepsy patients. Only respiratory-related brain pulsations were clearly increased with no changes in either physiological cardiorespiratory rates or head motion between the subjects. The regional alterations in brain pulsations suggest that mechanisms driving the cerebrospinal fluid homeostasis may be altered in epilepsy. Magnetic resonance encephalography has both increased sensitivity and high specificity for detecting the increased brain pulsations, particularly in times when other tools for locating epileptogenic areas remain inconclusive.

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Section: Discussionmentioning

confidence: 99%

Respiratory-related brain pulsations are increased in epilepsy—a two-centre functional MRI study

Kananen

Helakari

Korhonen

et al. 2020

Brain Communications

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“…A 1984 critical review of the literature established that sleep deprivation activates IEDs, independent of its effects on sleep . Since then, at least 8 more studies agree with this …”

Section: Insufficient Sleep and Electroencephalogram Activationmentioning

confidence: 96%

Insufficient Sleep, Electroencephalogram Activation, and Seizure Risk: Re‐Evaluating the Evidence

Rossi

Joe

Makhija

et al. 2020

Annals of Neurology

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“…Characteristic discharges. Research by Del Felice et al [30], Nayak et al [31], Giorgi et al [32] focuses on the analysis of interictal epileptiform discharges (IEDs). This characteristic brain activity, which differs from that during an epileptic seizure, is due to different mechanisms activated by specific ligands [33].…”

Section: Brief Description Of the State Of Knowledgementioning

confidence: 99%

“…In an earlier work by Giorgi et al [35] it was found that sleep deprivation influences the higher incidence of IEDs. In the study by Giorgi et al [32], which qualified for the review, the researchers wanted to check whether morning sleep is associated with an increased incidence of IEDs, compared to physiological sleep. Their aim was also to observe any abnormalities in sleep architecture.…”

Section: Brief Description Of the State Of Knowledgementioning

confidence: 99%

“…Giorgi et al [32], at the very beginning of the publication, note that in 40% of people with focal epilepsy, IEDs are not observed, but if they do occur, their number increases with sleep deprivation. In the conducted study, polysomnography (PSG) compared single REM/NREM sleep cycles after deprivation sleep and during physiological sleep.…”

Section: Brief Description Of the State Of Knowledgementioning

confidence: 99%

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Bilateral dependence of sleep disorders and temporal lobe epilepsy – literature review

Drabik¹,

Sarnacki²,

Miziak³

2021

Med Og Nauk Zdr.

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Introduction. The analysis of sleep and its phases in the context of various pathophysiologies has attracted increasing attention from the scientific community; therfore, this review of the literature focuses on temporal lobe epilepsy (TLE). Objective. The aim of the review is to systematize and update the knowledge and research currently available on the interplay of sleep deprivation and seizures in TLE, with a focus on MTLE. Materials and method. The following keyword combinations were used to search the Pubmed, Science Direct and Google Scholar databases: sleep disturbance in mesial temporal lobe epilepsy, sleep in temporal lobe epilepsy, nocturnal temporal lobe epilepsy, temporal epilepsy sleep disturbance. After applying exclusion criteria, 23 papers were selected for the review. Brief description of the state of knowledge. The publications qualified for the review were divided into 7 categories in terms of the subject of the publication. These categories relate to characteristic brain waves, memory and its consolidation processes, heart and sleep apnea, anti-epileptic drugs, motor disorders and lateralization of the discharges. Articles that did not fit into any of the previously mentioned categories were placed in the 'Other' group. Conclusions. It is agreed that sleep is an important factor that should be taken into account when selecting the appropriate treatment and researching new AEDs. Moreover, sleep is significant to the patient›s quality of life, has a profound impact on its components, for example, physical and social functions, emotions and leisure, but may also influence the effectiveness of therapy.

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Cyclic alternating pattern and interictal epileptiform discharges during morning sleep after sleep deprivation in temporal lobe epilepsy

Cited by 14 publications

References 41 publications

Respiratory-related brain pulsations are increased in epilepsy—a two-centre functional MRI study

Respiratory-related brain pulsations are increased in epilepsy—a two-centre functional MRI study

Insufficient Sleep, Electroencephalogram Activation, and Seizure Risk: Re‐Evaluating the Evidence

Bilateral dependence of sleep disorders and temporal lobe epilepsy – literature review

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