Cyclic Adenosine Monophosphate: A Central Player in Gamete Development and Fertilization, and Possible Target for Infertility Therapies

Abstract

Human infertility, of both male and female origin, is often caused by the deficient response of the testis and the ovary to hormonal stimuli that govern sperm and oocyte development and fertilization. The effects of hormones and other extracellular ligands involved in these events are often mediated by G-protein-coupled receptors that employ cyclic adenosine monophosphate (cAMP) as the principal second messenger transducing the receptor-generated signal to downstream elements. This opinion article summarizes the actions of cAMP in sperm and oocyte development and fertilization, leading to therapeutic actions targeting cAMP metabolism to alleviate human male and female infertility.

Methyltransferase‐like 3 mediated RNA m6A modifications in the reproductive system: Potentials for diagnosis and therapy

“…2 At present, mainly due to abnormal gamete development and tumorigenesis in the reproductive organs, infertility or phenotypic differences often arise despite the transference of genetic information from both parents to their offspring. 3 However, the mechanisms underlying these intricate regulatory processes remain unclear.…”

“…In mammals, germline development relies on the precise regulation of gene expression at the transcriptional, posttranscriptional and translational levels to ensure the formation of normal haploid gametes 2 . At present, mainly due to abnormal gamete development and tumorigenesis in the reproductive organs, infertility or phenotypic differences often arise despite the transference of genetic information from both parents to their offspring 3 . However, the mechanisms underlying these intricate regulatory processes remain unclear.…”