“…According to the electronic and structural properties of phosphonates such as the phosphorus-carbon stable covalent bond and their high potential in biology, Phosphonate chemistry can be introduced as a suitable candidate for the production of biomaterials [ [1] , [2] , [3] ]. Phosphonates have a wide range of application in radiopharmaceuticals [ 4 ], enzyme inactivators [ 5 ], HIV protease inhibitor [ 6 ], cardiovascular drugs [ 7 ], anti-parasitic drugs [ 8 ], and antiviral drug [ 9 ]. On 11th March 2020, the World Health Organization (WHO) categorized COVID-19, as a pandemic disease [ [10] , [11] ].…”