Cycle and gender-specific cerebral activation during a verb generation task using fMRI: Comparison of women in different cycle phases, under oral contraception, and men

Rumberg, Bastian; Baars, Anneke; Fiebach, Jochen B.; Ladd, Mark E.; Forsting, Michael; Senf, Wolfgang; Gizewski, Elke R.

doi:10.1016/j.neures.2009.12.011

Cited by 35 publications

(21 citation statements)

References 28 publications

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“…A PET study of asymptomatic women showed decreased activation of the dorsolateral prefrontal cortex, inferior parietal lobule, and posterior inferior temporal cortex during leuprolide-induced hypogonadism, whereas the expected pattern of cortical activity returned following either estradiol or progesterone add-back (23). Studies of the effects of combined oral contraceptives have identified increased activity in the medial prefrontal cortex, ACC, dorsolateral prefrontal cortex, and inferior frontal gyrus (1,239,263), and decreased activity in posterior cingulate cortex, medial frontal gyrus, inferior frontal gyrus, and insula (1,109).…”

Section: Network Neuroscience: Reproductive Steroids Regulate the Neumentioning

confidence: 99%

Reproductive Steroid Regulation of Mood and Behavior

Schiller

Johnson

Abate

et al. 2016

Comprehensive Physiology

152

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In this article, we examine evidence supporting the role of reproductive steroids in the regulation of mood and behavior in women and the nature of that role. In the first half of the article, we review evidence for the following: (i) the reproductive system is designed to regulate behavior; (ii) from the subcellular to cellular to circuit to behavior, reproductive steroids are powerful neuroregulators; (iii) affective disorders are disorders of behavioral state; and (iv) reproductive steroids affect virtually every system implicated in the pathophysiology of depression. In the second half of the article, we discuss the diagnosis of the three reproductive endocrine-related mood disorders (premenstrual dysphoric disorder, postpartum depression, and perimenopausal depression) and present evidence supporting the relevance of reproductive steroids to these conditions. Existing evidence suggests that changes in reproductive steroid levels during specific reproductive states (i.e., the premenstrual phase of the menstrual cycle, pregnancy, parturition, and the menopause transition) trigger affective dysregulation in susceptible women, thus suggesting the etiopathogenic relevance of these hormonal changes in reproductive mood disorders. Understanding the source of individual susceptibility is critical to both preventing the onset of illness and developing novel, individualized treatments for reproductive-related affective dysregulation. © 2016 American Physiological Society. Compr Physiol 6:1135-1160, 2016e.

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Section: Network Neuroscience: Reproductive Steroids Regulate the Neumentioning

confidence: 99%

Reproductive Steroid Regulation of Mood and Behavior

Schiller

Johnson

Abate

et al. 2016

Comprehensive Physiology

152

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“…In the migraine field, there are a number of “animal models”, however, most use male animals (e.g., (113, 186)), which confounds sex differences in migraine. Another approach to study the influence of hormones is to investigate short term and long term effects of contraceptive use on migraine, as there is compelling evidence that oral contraceptive alter brain function (187, 188) and structure in regions such as the prefrontal cortex, pre- and post-central gyri, parahippocampal and fusiform gyri, and temporal regions (43). However, the impact of oral contraceptives on brain function and structure in migraine susceptible individuals remains unknown.…”

Section: Future Directionsmentioning

confidence: 99%

“…A: Incidence of Migraine across the Menstrual Cycle : More than 1/5 female migraineur aged 30-34 years have migraine in ≥50% of menstruations (187). Data suggest that migraine is most prevalent in the first few days at the onset of menses and the first few days at the beginning of the cycle (111).…”

Section: Figurementioning

confidence: 99%

Sex and the migraine brain

Borsook

Erpelding

Lebel

et al. 2014

Neurobiology of Disease

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The brain responds differently to environmental and internal signals that relates to the stage of development of neural systems. While genetic and epigenetic factors contribute to a premorbid state, hormonal fluctuations in women may alter the set point of migraine. The cyclic surges of gonadal hormones may directly alter neuronal, glial and astrocyte function throughout the brain. Estrogen is mainly excitatory and progesterone inhibitory on brain neuronal systems. These changes contribute to the allostatic load of the migraine condition that most notably starts at puberty in girls.

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“…Different from these two studies, the women in our study were all on contraceptives. According to theoretical considerations contraceptives eliminate hormonal peak levels due to the artificial harmonization [17]. This plus the vague timing of the assessments in regard to the menstrual cycle may account for the different observations.…”

Section: Discussionmentioning

confidence: 99%

“…In the study by Fernandez there was greater right hemisphere activation during the luteal phase. Similarly another fMRI study showed different fMRI activation at the luteal phase and menstruation using a word generation task [17]. Therefore, we asked all women about the time of menstruation during the study phase.…”

Section: Introductionmentioning

confidence: 99%

Menstrual cycle corrupts reliable and valid assessment of language dominance: Consequences for presurgical evaluation of patients with epilepsy

Helmstaedter

Jockwitz

2015

Seizure

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A high intraindividual variability of language dominance patterns is indicated in women when assessed repeatedly by fTCD. Menstrual cycle appeared to be the source of inconsistency. The finding challenges the use of non-deactivating methods for language dominance assessment in epilepsy. Support for this is demonstrated with a female patient with epilepsy in whom language dominance assessed by repeated fMRI and fTCD varied concordantly with cycle but not so the repeated intracarotidal amobarbital test.

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Cycle and gender-specific cerebral activation during a verb generation task using fMRI: Comparison of women in different cycle phases, under oral contraception, and men

Cited by 35 publications

References 28 publications

Reproductive Steroid Regulation of Mood and Behavior

Reproductive Steroid Regulation of Mood and Behavior

Sex and the migraine brain

Menstrual cycle corrupts reliable and valid assessment of language dominance: Consequences for presurgical evaluation of patients with epilepsy

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