The objective was to examine the relation between bullying and legal and illegal drug use in adolescents, using data bases such as EBSCO CINAHL, EBSCO Academic Research complete, MEDLINE, Elsevier, Springer, Cochrane, PUBMED, as well as in sources of gray literature like Open Access, with the descriptors: drug abuse, drug addiction, drug dependence, bullying, cyberbullying, young adolescence, among others, in the month of October of 2016. The results obtained showed that men are the principal actors of bullying and that the aggressors in their majority are drug consumers, besides the increase in age decreases the probability of being a victim, but increases the probability of being an aggressor.