CyberKnife stereotactic radiotherapy for isolated recurrence in the prostatic bed

Abstract

Our experience shows that SBRT with CyberKnife for isolated nodal relapse is a safe and well-tolerated treatment.

Stereotactic radiotherapy for prostate bed recurrence after prostatectomy, a multicentric series

“…Jereczek‐Fossa et al in 2012 published a retrospective analysis of 34 patients treated with SSRT (30 Gy in five fractions), including 19 cases of re‐irradiation for local recurrence, and reported a 30‐month PFS rate of 42.6%. Another monocentric case series was published by the University of Florence in 2016, reporting data on 16 patients treated with SSRT and showing a significant biochemical response in all but one patient . However, these series included patients undergoing re‐irradiation and patients with regional and/or nodal metastases, and a direct comparison with present analysis is difficult.…”

Reirradiation for isolated local recurrence of prostate cancer: Mono-institutional series of 64 patients treated with salvage stereotactic body radiotherapy (SBRT)

“…Our excellent rates of GU and GI side effects confirm the good profile of toxicity reported also by other investigators in smaller series. 17,18,20,21,23,25 For example, Leroy et al 20 in a series of 23 patients treated with SBRT (36 Gy in 6 fractions) did not observe Grade 4 or 5 toxicity. Importantly, in our series no patient experienced urinary incontinence, a typical complication of other salvage local therapies.…”

“…The efficacy of salvage reirradiation for locally recurrent PCa has been evaluated by several investigations. [14][15][16][17][18][19][22][23][24][25][26][28][29][30][31][32][33][34] The first report on re-EBRT by Vavassori et al 15 including six cases treated by CyberKnife, showed the feasibility of reirradiation with an acceptable rate of acute and early chronic toxicity (median follow-up was 11.3 months). These preliminary findings were then confirmed by the successive series.…”

“…7,12 As far as reirradiation is concerned, the vast majority of patient series were treated with brachytherapy (BRT). In the last years, along with the improvement in radiotherapy (RT) planning and delivery technology, several reports on salvage EBRT have been published [14][15][16][17][18][19][20][21][22][23][24][25][26][27] (Table 1).…”

Re: Stereotactic Body Re-irradiation Therapy for Locally Recurrent Prostate Cancer After External-beam Radiation Therapy: Initial Report

“…Despite numerous studies on reirradiation for various tumors sites, experience in retreatment of prostate cancer is very limited and includes mainly brachytherapy series [1]. Since the review by Alongi et al in 2013 [1], a couple of new series have been published and show that both technology and radiobiology play a role [2,3]. Using advanced imaging (recurrence identified by magnetic resonance, staging based on [ 18 F]-fluorocholine positron emission tomography), highly selective radiotherapy modalities (stereotactic body radiotherapy and image-guided intensity-modulated radiotherapy), and extreme hypofractionation (doses > 6 Gy/fraction), Janoray et al showed that reirradiation is safe and may offer a medium-term cure in a good proportion of patients.…”