Cyanuric and thiocyanuric esters as carriers of boron-containing fragments and their fragmentation in mass spectrometry

Azev, Yuri A.; Dülcks, Thomas; Gabel, Detlef

doi:10.1016/j.tetlet.2003.09.153

Cited by 20 publications

(11 citation statements)

References 6 publications

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“…The mass spectrum of morpholine showed that the ring was cleaving as a result of the loss of carbonyl group as given in literature [20,21]. And another important fragment was the cleavage of the morpholine ring (m/z 86) from the structure (compound 1, 2 and 12) .…”

Section: Scheme 1 General Synthetic Pathwaymentioning

confidence: 69%

Synthesis and structure-activity relationship study: Anticancer chalcones derived from 4'-morpholinoacetophenone

Kurşun‐Aktar¹,

Oruç‐Emre²,

Karaküçük‐İyidoğan³

et al. 2017

mpj

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The aim of this research was to synthesize chalcone derivatives containing morpholine ring and to investigate their antiproliferative activity. The 3-aryl-1-[4-(morpholin-4-yl)phenyl]prop-2-en-1-one derivatives were synthesized and evaluated for their in vitro antiproliferative activities on C6 cells (Rat glioma cell line) and HeLa cells (Human cervix adenocarcinoma), using the BrdU ELISA assay. The calculation of ADME properties of new chalcone derivatives was used by topological polar surface area (TPSA), absorption (ABS%) and Lipinski's rules. Most of the compounds exhibited significantly antiproliferative activity on two cell lines. Among the screened compounds, compound 7, 10, 11 and 12 revealed higher antiproliferative activity than cisplatin which was used as reference drug. Compound 11 on HeLa cell and compound 10 on C6 cell line are the most effective compared with cisplatin. Keywords

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Section: Scheme 1 General Synthetic Pathwaymentioning

confidence: 69%

Synthesis and structure-activity relationship study: Anticancer chalcones derived from 4'-morpholinoacetophenone

Kurşun‐Aktar¹,

Oruç‐Emre²,

Karaküçük‐İyidoğan³

et al. 2017

mpj

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“…The reaction of cyanuric chloride with hydroxyaryl(alkyl) compounds affords 2,4,6-triaryl(alkyl)oxy-1,3,5-triazines (5) [557,564,565].…”

Section: Synthesismentioning

confidence: 99%

“…In the literature, methods of synthesis of tris(aryl)-1,3,5-triazines by cyclotrimerization of aromatic nitriles in solvent-free conditions have been described [566,571]. In general, the best routes available to obtain trisubstituted 1,3,5-triazines are substitution reactions of chlorine atoms of cyanuric chloride with different nucleophiles [207,497,522,556,565,[573][574][575][576][577][578][579][580][581][582][583]; it is possible to substitute one, two or three selectively (Section 20.4.5.3).…”

Section: Synthesismentioning

confidence: 99%

“…Thus, when 1,3,5-triazine is allowed to react with dinitrogen pentoxide, at 0 C, and quenched with methanol the cis and trans isomers of 2,4,6-trimethoxy-1,3,5-trinitrohexahydro-1,3,5-triazine 337 and 338 can be isolated in equimolar ratio [676] (Scheme 20.96). Alkylation of thiocyanuric has been described [565]. Phase-transfer has been employed to catalyze polycondensation of 6-dialkylamino-1,3,5-triazine-2,4-dithiols with 1,10-dibromodecane [677].…”

Section: Reactions With Electrophilic Reagentsmentioning

confidence: 99%

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Six‐Membered Heterocycles: Triazines, Tetrazines and Other Polyaza Systems

Oliva¹,

Laza²,

Ocáriz³

2011

Modern Heterocyclic Chemistry

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“…On the other hand, 1,3,5-triazines are another important class of π-conjugated heterocycles with nitrogen atoms in the six-membered ring each with a lone-pair of electrons pointing outside the ring. 1,3,5-Triazine derivatives are of great interest due to their importance as drug precursors and additives for stabilizing light emission in OLEDs [5][6][7][8]. Carbazole-triazine hybrids have gained special importance in the field of organic electronics as electroluminescent materials [9,10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Crystal Structure of 9-(4,6-dichloro-1,3,5-triazin-2-yl)-9H-carbazole

et al. 2011

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A carbazole-triazine hybrid was prepared by addition-elimination between carbazole and 2,4,6-trichlorotriazine in the presence of base. The compound shows intensely blue fluorescence both in solution and solid state when irradiated with UVradiation. The structure of (3) was supported by the spectroscopic data and unambiguously confirmed by the single crystal X-ray diffraction data. It was crystallized in the monoclinic space group C2/c with unit cell dimensions a = 20.280(3), b = 8.0726(14), c = 16.005(3) Å, α = γ = 90°, β = 98.947(3)°, V = 2588.3(8) Å³, Z = 8.

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Cyanuric and thiocyanuric esters as carriers of boron-containing fragments and their fragmentation in mass spectrometry

Cited by 20 publications

References 6 publications

Synthesis and structure-activity relationship study: Anticancer chalcones derived from 4'-morpholinoacetophenone

Synthesis and structure-activity relationship study: Anticancer chalcones derived from 4'-morpholinoacetophenone

Six‐Membered Heterocycles: Triazines, Tetrazines and Other Polyaza Systems

Synthesis and Crystal Structure of 9-(4,6-dichloro-1,3,5-triazin-2-yl)-9H-carbazole

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