Cyanosis, hemolysis, decreased HbA1c and abnormal co-oximetry in a patient with hemoglobin M Saskatoon [HBB:c.190C &gt; T p.His64Tyr]

Göttgens, Eva-Leonne; Baks, Kristian; Harteveld, Cornelis L.; Goossens, Kristel; Gammeren, Adriaan J. van

doi:10.1080/16078454.2021.1999048

Cited by 1 publication

(5 citation statements)

References 27 publications

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“…28 These include hemoglobin M-Milwaukee-2, 30,34 hemoglobin M-Iwate, 22 and hemoglobin M-Saskatoon. 28 If there is concern for a methemoglobin, it is important to assess an arterial sample with CO-oximetry and understand the limitations of both tests.…”

Section: Methemoglobin and Hemoglobin Variants -Is Spo 2 Still Accurate?mentioning

confidence: 99%

“…This resulted in additional workup of a neonate with cyanosis, before the variant hemoglobin was identified 33 . Several hereditary methemoglobin variants present with decreased SpO 2 and normal SaO 2 , unlike the traditional methemoglobin variants, likely due to their unstable nature 28 . These include hemoglobin M‐Milwaukee‐2, 30,34 hemoglobin M‐Iwate, 22 and hemoglobin M‐Saskatoon 28 .…”

Section: Methemoglobin and Hemoglobin Variants – Is Spo2 Still Accurate?mentioning

confidence: 99%

“…22 Patients with unexplained low SpO 2 and a low SaO 2 who are clinically well without evidence of end organ damage should be investigated for low oxygen affinity hemoglobinopathy, especially if there is a family history. 28 Not all low oxygen affinity hemoglobin variants result in low SaO 2 . Several hemoglobin variants are associated with a low SpO 2 but a normal SaO 2 level.…”

Section: Methemoglobin and Hemoglobin Variants -Is Spo 2 Still Accurate?mentioning

confidence: 99%

“…33 Several hereditary methemoglobin variants present with decreased SpO 2 and normal SaO 2 , unlike the traditional methemoglobin variants, likely due to their unstable nature. 28 These include hemoglobin M-Milwaukee-2, 30,34 hemoglobin M-Iwate, 22 and hemoglobin M-Saskatoon. 28 If there is concern for a methemoglobin, it is important to assess an arterial sample with CO-oximetry and understand the limitations of both tests.…”

Section: Methemoglobin and Hemoglobin Variants -Is Spo 2 Still Accurate?mentioning

confidence: 99%

“…Other examples of low SpO 2 and low SaO 2 related to low oxygen affinity hemoglobins include hemoglobin Basset, hemoglobin Rothschild, and hemoglobin Canebière 22 . Patients with unexplained low SpO 2 and a low SaO 2 who are clinically well without evidence of end organ damage should be investigated for low oxygen affinity hemoglobinopathy, especially if there is a family history 28 …”

Section: Methemoglobin and Hemoglobin Variants – Is Spo2 Still Accurate?mentioning

confidence: 99%

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Understanding pulse oximetry in hematology patients: Hemoglobinopathies, racial differences, and beyond

2022

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Pulse oximetry (SpO 2 ) is a widely used, non-invasive method of estimating arterial oxygen saturation. Measurement of SpO 2 relies on comparing the relative absorption of light in the red and infrared regions with the expected absorption pattern of oxygenated and deoxygenation adult hemoglobin. As this screening tool has entered common clinical use, test limitations have emerged, including concern about the risk of overestimation of oxygen saturation by pulse oximetry in a disproportionate number of people with dark skin pigment, leading to potential for underdiagnosis of true hypoxemia. In addition, a range of challenges may arise in patients with increased levels of methemoglobinwhether acquired or inheritedcarboxyhemoglobin, or in patients with a subset of inherited variant hemoglobins. It is important for Hematologists, and indeed all clinicians who rely on pulse oximetry, to understand the principles and limitations of this ubiquitous test.

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Section: Methemoglobin and Hemoglobin Variants -Is Spo 2 Still Accurate?mentioning

confidence: 99%

Section: Methemoglobin and Hemoglobin Variants – Is Spo2 Still Accurate?mentioning

confidence: 99%

Section: Methemoglobin and Hemoglobin Variants -Is Spo 2 Still Accurate?mentioning

confidence: 99%

Section: Methemoglobin and Hemoglobin Variants -Is Spo 2 Still Accurate?mentioning

confidence: 99%

Section: Methemoglobin and Hemoglobin Variants – Is Spo2 Still Accurate?mentioning

confidence: 99%

See 3 more Smart Citations

Understanding pulse oximetry in hematology patients: Hemoglobinopathies, racial differences, and beyond

2022

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show abstract

Cyanosis, hemolysis, decreased HbA1c and abnormal co-oximetry in a patient with hemoglobin M Saskatoon [HBB:c.190C > T p.His64Tyr]

Cited by 1 publication

References 27 publications

Understanding pulse oximetry in hematology patients: Hemoglobinopathies, racial differences, and beyond

Understanding pulse oximetry in hematology patients: Hemoglobinopathies, racial differences, and beyond

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