Cyanogenic Glycosides

Anjum, Nadira; Sheikh, Mohd Aaqib; Saini, Charanjiv Singh; Hameed, Fozia; Sharma, Harish Kumar; Bhat, Anju

doi:10.1201/9781003178446-10

Cited by 3 publications

(2 citation statements)

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“…Tis is a mixed idea, especially since this extraction procedure is more benefcial than harmful. Indeed, as much as it could facilitate the release of certain active principles often present in the plant in the form of glucosides, it could not only release specifc toxic secondary metabolites such as cyanogenic glycosides [122] but also deteriorate the active ingredient when the latter is thermolabile [123][124][125]. Terefore, this practice remains to be assessed case-by-case, and only experimental work could determine its fair value.…”

Section: LVmentioning

confidence: 99%

Ethnomedicinal Knowledge of Plants Used in Nonconventional Medicine in the Management of Diabetes Mellitus in Kinshasa (Democratic Republic of the Congo)

Chiribagula Valentin,

Ndjolo Philippe,

Mboni Henry

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Background. People with diabetes, herbalists, and traditional medicine practitioners (TMPs) from Kinshasa use plants to treat diabetes, but no study has inventoried the plants used by these populations. The present study was conducted to identify the plants used in Kinshasa to treat diabetes mellitus. Methods. The survey conducted in the form of a semistructured interview between March 2005 and August 2006 made it possible to collect ethnobotanical information from people with diabetes (n = 126), herbalists (n = 80), and TMPs (n = 120). Results. The 326 subjects consulted (sex ratio M/F = 0.6, age 51 ± 7 years, and experience: 17 ± 5 years) provided information on 71 plants, most of which are trees (35%), belonging to 38 families dominated by Fabaceae (19.7%) and indicated in 51 other cases of consultation dominated by malaria (12%). From these 71 plants derived, 86 antidiabetic recipes were administered orally, where the leaf is the most used part (>50%) and the decoction (>46%) is the most common mode of preparation. This study reports for the first time the antidiabetic use of 11 species, among which Tephrosia vogeliiX (0.08), Chromolaena corymbosaX (0.06), and Baphia capparidifoliaX (0.06) present the highest consensus indexes (CI) and Marsdenia latifoliaW (UVp = 0.08) and Rauvolfia manniiX (UVp = 0.06) present the highest UVs. Conclusion. The results show that Kinshasa people treat diabetes using several plants. Some are specific to the ecological environment; others are used in other regions. Pharmacological studies are underway to assess the therapeutic efficacy of these plants.

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Section: LVmentioning

confidence: 99%

Ethnomedicinal Knowledge of Plants Used in Nonconventional Medicine in the Management of Diabetes Mellitus in Kinshasa (Democratic Republic of the Congo)

Chiribagula Valentin,

Ndjolo Philippe,

Mboni Henry

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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“…Numerous surveys have indicated that plants containing cyanide have been associated with stunted growth, limb abnormalities, microcephaly, ocular malformations, reduced fetal body weight, absence of tail and anus, underdeveloped external genitalia, and embryonic mortality. [ 19 ] Various mechanisms can lead to the teratogenic effects of hydrogen cyanide (HCN). The release of HCN within the body has the potential to impede regular cellular mechanisms and cause disturbances in the development of the fetus.…”

Section: Introductionmentioning

confidence: 99%

Exploration of Teratogenic Effects of Bambusa vulgaris on Wistar Rats by Evaluating Morphological and Skeletal Parameters

Acharya,

Behera,

Chowdhury

et al. 2024

Macromolecular Symposia

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Bambusa vulgaris is a commonly consumable plant, which is widely utilized by indigenous peoples as a source of food. Consumption of these plant products in various forms is typically acceptable due to their distinct tastes, and aromatic flavor. However, there is little information on the plant's safety and toxicity profile. Although toxicity information on B. vulgaris is readily available, the impact of plants during pregnancy has yet to be fully explored. To determine the possible mechanism behind teratogenicity, pregnant albino Wistar rats are administered aqueous extracts of B. vulgaris in a dose‐dependent manner. For determining the structural malformations, Teratogenicity indices include maternal common physiological parameters, number of implantations and fetal indices, number of live, resorpsed, and dead somites, morphological malformations, and skeletal malformations of different organs are evaluated by comparing different test groups with control groups. Most developmental indices, including implantation and fetalindices, vertebral, organ, and skeletal structures are significantly altered by the crude extract at higher dosages in treated as compared to control animals. The administration of aqueous extract of B. vulgaris during the organogenesis phase in rats has a considerable deleterious effect on embryonic and fetal developmental indices. It ruthlessly impacts the embryo's numerous organs as well as their typical physiological processes in a dose‐dependent way. The present investigation validates the capacity of B. vulgaris to cause developmental toxicity in Wistar rats, as evidenced by significant alterations in their gestational morphological, structural, and skeletal anatomy and physiology. It is recommended that further scientific studies be conducted to evaluate the more advanced mechanisms of teratogenicity associated with B. vulgaris.

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